Crucial role of impaired Kupffer cell phagocytosis on the decreased Sonazoid‐enhanced echogenicity in a liver of a nonalchoholic steatohepatitis rat model

Yoshikawa, Shohei; Iijima, Hiroko; Saito, Masaki; Tanaka, Hironori; Imanishi, Hiroyasu; Yoshimoto, Noriko; Yoshimoto, Tomohiro; Futatsugi-Yumikura, Shizue; Nakanishi, Kenji; Tsujimura, Tohru; Nishigami, Takashi; Kudo, Atsushi; Arii, Shigeki; Nishiguchi, Shuhei

doi:10.1111/j.1872-034x.2010.00670.x

Cited by 21 publications

(24 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although multiple factors could affect WR, reduced Kupffer cell phagocytic function may be one of the most conceivable reasons. It was reported that nonalcoholic steatohepatitis in a rat model showed reduced Kupffer cell phagocytic function, with no changes in the numbers of Kupffer cells [24]. More recently, Park et al.…”

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced ultrasonography of the hepatic vein in normal dogs

Morishita

Hiramoto

Osuga

et al. 2016

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

Contrast-enhanced ultrasonography (CEUS) of the hepatic vein can assess intrahepatic hemodynamic changes and has been studied as a noninvasive method to assess the severity of portal hypertension and hepatic fibrosis in humans. However, few reports have described its usefulness in veterinary medicine. The purpose of this study was to characterize CEUS findings of the hepatic vein in normal dogs and assess the repeatability of this method both in a conscious group (n=6) and a sedated group (n=6). Sonazoid® (0.01 ml/kg) was used as a contrast agent, and scanning of the hepatic vein was performed for 2 min. Time-intensity curves were generated from regions of interest in the hepatic vein. Four perfusion parameters were measured for quantitative analysis: hepatic vein arrival time (HVAT), time to peak (TTP), time to peak phase (TTPP) and wash-out ratio (WR). CEUS examinations were performed three times in each dog. The median (range) values of HVAT, TTP, TTPP and WR in the conscious group were 13.5 sec (9–22 sec), 12.5 sec (6–24 sec), 8 sec (6–13 sec) and 78.0% (60.7–91.7%), respectively. Median (range) values of HVAT, TTP, TTPP and WR in the sedated group were 12 sec (8–17 sec), 12.5 sec (9–17 sec), 9 sec (7–13 sec) and 84.1% (63.0–94.4%), respectively. The coefficients of variation of these parameters in the conscious and sedated groups were 7.6–29.7% and 11.8–14.8%, respectively.

show abstract

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced ultrasonography of the hepatic vein in normal dogs

Morishita

Hiramoto

Osuga

et al. 2016

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

show abstract

“…If the Kupffer cells phagocytose more contrast agent, less contrast agent can flow into the HV, and the PV‐HV AT interval can be prolonged. However, the influence on the AT interval might be relatively small because it would take more time for Kupffer cells to phagocytose contrast agents …”

Section: Discussionmentioning

confidence: 99%

Obliteration of gastric varices improves the arrival time of ultrasound contrast agents in hepatic artery and vein

Furuichi

Sugimoto

Taira

et al. 2013

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…The postvascular phase was observed using the advanced dynamic flow (ADF) mode in some cases. Using the ADF mode, Sonazoid bubbles phagocytosed by Kupffer cells were destroyed, with a high MI of 1.0 [5]. Since the presence or absence of hypoechoic areas in the postvascular phase cannot be readily identified, particularly in high-echoic lesions, this procedure is useful for such determination.…”

Section: Methodsmentioning

confidence: 99%

“…All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 [5]. Informed consent was obtained from all patients for being included in the study.…”

Section: Consentmentioning

confidence: 99%

Evaluation of Hemodynamics in Focal Steatosis and Focal Spared Lesion of the Liver Using Contrast-Enhanced Ultrasonography with Sonazoid

Shiozawa

Watanabe

Ikehara

et al. 2014

Radiology Research and Practice

View full text Add to dashboard Cite

We aim to investigate the hemodynamics in focal steatosis and focal spared lesion of the liver using contrast-enhanced ultrasonography (CEUS) with Sonazoid. The subjects were 47 patients with focal steatosis and focal spared lesion. We evaluated enhancement patterns (hyperenhancement, isoenhancement, and hypoenhancement) in the vascular phase and the presence or absence of a hypoechoic area in the postvascular phase for these lesions using CEUS. Of the 24 patients with focal steatosis, the enhancement pattern was isoenhancement in 19 and hypoenhancement in 5. Hypoechoic areas were noted in the postvascular phase in 3 patients. Of the 23 patients with focal spared lesions, the enhancement pattern was isoenhancement in 18 and hyperenhancement in 5. No hypoechoic areas were noted in the postvascular phase in any patient. The hemodynamics in focal steatosis and focal spared lesions in nondiffuse fatty liver can be observed using low-invasive procedures in real-time by CEUS. It was suggested that differences in the dynamics of enhancement in the vascular phase of CEUS were influenced by the fat deposits in the target lesion, the surrounding liver parenchyma, and the third inflow.

show abstract

Crucial role of impaired Kupffer cell phagocytosis on the decreased Sonazoid‐enhanced echogenicity in a liver of a nonalchoholic steatohepatitis rat model

Abstract: CEUS with Sonazoid is a powerful evaluation tool to diagnose NASH from an early stage of the disease.

Cited by 21 publications

References 32 publications

Contrast-enhanced ultrasonography of the hepatic vein in normal dogs

Contrast-enhanced ultrasonography of the hepatic vein in normal dogs

Obliteration of gastric varices improves the arrival time of ultrasound contrast agents in hepatic artery and vein

Evaluation of Hemodynamics in Focal Steatosis and Focal Spared Lesion of the Liver Using Contrast-Enhanced Ultrasonography with Sonazoid

Contact Info

Product

Resources

About