Crucial Role of CD4+CD 25+ FOXP3+ T Regulatory Cell, Interferon-γ and Interleukin-16 in Malignant and Tuberculous Pleural Effusions

Ibrahim, Lamiaa; Salah, Manal; Rahman, Azema Abd El; Zeidan, Amany; Ragb, Maha

doi:10.3109/08820139.2012.736116

Cited by 18 publications

(13 citation statements)

References 27 publications

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“…In addition, the CD4 + CD25 + Foxp3 + Treg cells play an important role in controlling autoimmune reactions (Maggi et al, 2005;Xing et al, 2012), cell transplantation (Velaga et al, 2013), and infection immunity (Ibrahim et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis

Zheng

Chen²,

Xiao³

et al. 2014

Immunological Investigations

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Regulatory IL-10-producing CD1d(high)CD5(+)CD19(+) B cells and CD4(+)CD25(+)Foxp3(+) T cells have been found to modulate immune responses in autoimmunity, infection, and cancer, but the interaction between these two cell subsets remains unclear. Through cell culture and flow cytometry (FACS), we analyzed the interaction of regulatory T cells (Tregs) and regulatory B cells (Bregs). A neutralizing antibody was used to determine the role of CD5 and CD72 in maintaining regulatory T and B cell homeostasis. We found that CD19(+)CD5(+)CD1d(hi) Bregs induced expansion of CD4(+)Foxp3(+) Tregs, and CD4(+)CD25(+) Tregs also induced expansion of IL-10-expressing Bregs. Once CD72 or CD5 was blocked, both IL-10-expressing Bregs and CD4(+)Foxp3(+)Tregs were reduced in the different cultures. Finally, FACS analysis demonstrated that Foxp3(+)CD4(+)Treg cells were reduced in CD19(Cre) mice defective of CD5 on the surface of B cells. The study suggests that the interaction of CD5 and CD72 plays a critical role in maintaining regulatory T and B cell homeostasis.

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Section: Introductionmentioning

confidence: 99%

Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis

Zheng

Chen²,

Xiao³

et al. 2014

Immunological Investigations

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“…Investigators in large-scale studies have reported that lymphocytes play an important role in the pathogenesis of pleural effusion [14-17]. CD4 + T cells can be differentiated into interleukin 17 (IL-17)-producing T helper (Th17) cells.…”

Section: Introductionmentioning

confidence: 99%

Elevated pleural effusion IL-17 is a diagnostic marker and outcome predictor in lung cancer patients

Zhan

et al. 2014

Eur J Med Res

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BackgroundInterleukin 17 (IL-17) is a proinflammatory cytokine produced mainly by CD4+ T-lymphocytes and may be important in tumor cell growth and progression. In this study, we aimed to evaluate the diagnostic and prognostic value of pleural effusion levels of IL-17 in lung cancer patients with malignant pleural effusion (MPE).MethodsPleural effusion samples were collected from 78 lung cancer patients with MPE and from 45 patients with nonmalignant pleural effusion. Pleural fluid concentrations of IL-17 were measured by using enzyme-linked immunosorbent assays.ResultsMalignant effusion exhibited higher IL-17 levels than nonmalignant effusion (20.49 ± 5.27 pg/ml vs. 13.16 ± 2.25 pg/ml; P < 0.01). Lung cancer patients with pleural fluid IL-17 levels below 15 pg/ml had longer overall survival than those patients with higher levels (10.8 months vs. 4.7 months; P < 0.05). On the basis of multivariate analysis, we found that pleural fluid IL-17 level was an independent prognostic factor in lung cancer patients with MPE.ConclusionsMeasurement of IL-17 levels might be a useful diagnostic and prognostic test for lung cancer patients with MPE.

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“…Foxp3 (the forkhead/winged helix transcription factor) has a regulatory function in immunologic suppression and is correlated with the development of CD4 + CD25 + Treg cells (Aquino et al, 2013;Bruinsm et al, 2010;Ibrahim et al 2013). Wang et al (2008) have confirmed that cimetidine (CIM) serves as an adjuvant and suppresses the function of CD4 + CD25 + Treg cells, promotes both cellular and humoral responses and maintains homeostatic immunity in HBV DNA vaccine vaccinations (Wang et al, 2008).…”

Section: Discussionmentioning

confidence: 85%

SulfatedRadix Cyathulae officinalisPolysaccharides Act as Adjuvant via Promoting the Dendritic Cell Maturation and Suppressing Treg Frequency

Feng

Fan

et al. 2015

Immunological Investigations

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This study was conducted to evaluate the adjuvant potential of sulfated Radix Cyathulae officinalis Kuan polysaccharides (sRCPS) and their effects on specific cellular and humoral immune responses to hepatitis B subunit vaccine in mice. Our data demonstrated that sRCPS significantly promoted the rHBsAg-specific IgG, IgG1, IgG2a, and IgG2b antibody titers, the activities of natural killer cells (NK) and cytotoxic T lymphocytes (CTL), T cells proliferation, and phagocytic capacity of peritoneal macrophages. Furthermore, sRCPS increased the levels of IL-4, IL-2, and IFN-γ in CD4(+)T cells and the level of IFN-γ in CD8(+)T cells. In addition, sRCPS enhanced the expression of CD40(+), CD80(+), CD86(+), MHC I and MHC II in dendritic cells (DCs) and upregulated the mRNA levels of MHC I, MHC II. sRCPS downregulated the frequency of CD4(+)CD25(+)Foxp3(+) Treg cells. sRCPS increased both cellular and humoral immune responses by upregulating DC maturation, and suppressing the frequency of Treg cells.

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Crucial Role of CD4+CD 25+ FOXP3+ T Regulatory Cell, Interferon-γ and Interleukin-16 in Malignant and Tuberculous Pleural Effusions

Cited by 18 publications

References 27 publications

Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis

Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis

Elevated pleural effusion IL-17 is a diagnostic marker and outcome predictor in lung cancer patients

SulfatedRadix Cyathulae officinalisPolysaccharides Act as Adjuvant via Promoting the Dendritic Cell Maturation and Suppressing Treg Frequency

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