Crucial players in Alzheimer’s disease and diabetes mellitus: Friends or foes?

Kubis-Kubiak, Adriana; Rorbach-Dolata, Anna; Piwowar, Agnieszka

doi:10.1016/j.mad.2019.03.008

Cited by 33 publications

(30 citation statements)

References 147 publications

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“…Remarkably, phytol, the most dominant compound in E convolvuloides EO, has been reported to possess excellent cholinesterase inhibitory activities in the studies of Elufioye et al 59 and Syad et al 60 According to Syad et al, 60 and memory dysfunction in patients with Alzheimer's disease. [64][65][66] Therefore, the results suggest the potential health benefits of the itors, they have shown to be accompanied by side effects. 67 Thus, as safer and effective substitutes to these synthetic compounds, tyrosinase inhibitors from natural sources such as plants are increasingly being considered for the control of skin pigmentation disorders.…”

Section: Different Major Constituents Have Also Been Reported In Thementioning

confidence: 90%

Chemodiversity and biological activity of essential oils from three species from the Euphorbia genus

Sinan

Etienne

Stefanucci

et al. 2020

Flavour & Fragrance J

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Several studies demonstrated the wide pharmacological properties of extracts and essential oils (EOs) prepared from Euphorbia species. In the present study, the chemical composition and biological activities of EOs from three different Euphorbia species were evaluated using in vitro methods. A total of 29, 33 and 42 constituents were identified in the EOs of E hirta, E convolvuloides and E heterophylla, respectively. The EOs exhibited in vitro radical scavenging potential in the ABTS assay (2.89‐21.50 mg/g). Additionally, an inhibitory effect on acetylcholinesterase (4.23‐5.12 mg/g) was detected. Besides, remarkable tyrosinase inhibition was reported by the EOs (95.24‐113.74 mg/g). Molecular docking was also performed to elucidate the binding interactions between selected EO components and enzymes. Phytol and geranyl‐(E)‐acetone had a good binding with tyrosinase in the molecular docking. This study highlighted the promising pharmacological profiles of these EOs as natural sources of antioxidants as well as cholinesterase and tyrosinase inhibitors that could be further explored in the management of human ailments in food and pharmaceutical industries.

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Section: Different Major Constituents Have Also Been Reported In Thementioning

confidence: 90%

Chemodiversity and biological activity of essential oils from three species from the Euphorbia genus

Sinan

Etienne

Stefanucci

et al. 2020

Flavour & Fragrance J

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“…Glycation is an endogenous process, triggered by high levels of glucose or by reactive endogenous aldehydes such as methylglyoxal or glyoxal, leading to the generation of a group of species known as advanced glycation end products (AGEs). Remarkably, high AGE levels have been detected in the brains of AD patients and glycosylation increased Aβ and NFTs proteolytic resistance [36,37].…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Role of Mesenchymal Stem Cells in Counteracting Oxidative Stress—Related Neurodegeneration

Angeloni

Gatti

Prata

et al. 2020

IJMS

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Neurodegenerative diseases include a variety of pathologies such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and so forth, which share many common characteristics such as oxidative stress, glycation, abnormal protein deposition, inflammation, and progressive neuronal loss. The last century has witnessed significant research to identify mechanisms and risk factors contributing to the complex etiopathogenesis of neurodegenerative diseases, such as genetic, vascular/metabolic, and lifestyle-related factors, which often co-occur and interact with each other. Apart from several environmental or genetic factors, in recent years, much evidence hints that impairment in redox homeostasis is a common mechanism in different neurological diseases. However, from a pharmacological perspective, oxidative stress is a difficult target, and antioxidants, the only strategy used so far, have been ineffective or even provoked side effects. In this review, we report an analysis of the recent literature on the role of oxidative stress in Alzheimer’s and Parkinson’s diseases as well as in amyotrophic lateral sclerosis, retinal ganglion cells, and ataxia. Moreover, the contribution of stem cells has been widely explored, looking at their potential in neuronal differentiation and reporting findings on their application in fighting oxidative stress in different neurodegenerative diseases. In particular, the exposure to mesenchymal stem cells or their secretome can be considered as a promising therapeutic strategy to enhance antioxidant capacity and neurotrophin expression while inhibiting pro-inflammatory cytokine secretion, which are common aspects of neurodegenerative pathologies. Further studies are needed to identify a tailored approach for each neurodegenerative disease in order to design more effective stem cell therapeutic strategies to prevent a broad range of neurodegenerative disorders.

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“…It is currently believed that aberrancy of glycogen synthase kinase-3 (GSK-3) could lead to AD [81], and GSK-3β might be the potential bridge between DM and AD. This is because GSK-3β abnormality could result in insulin resistance and insulin deficiency, thereby leading to phosphorylation dysregulation of tau protein (a pathological feature in AD) [82,83].…”

Section: Potential Dm-induced Mechanisms Leading To Admentioning

confidence: 99%

Potential Biochemical Mechanisms of Brain Injury in Diabetes Mellitus

Xing¹,

Tang²,

Lei³

et al. 2020

Aging and disease

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The goal of this review was to summarize current biochemical mechanisms of and risk factors for diabetic brain injury. We mainly summarized mechanisms published in the past three years and focused on diabetes induced cognitive impairment, diabetes-linked Alzheimer's disease, and diabetic stroke. We think there is a need to conduct further studies with increased sample sizes and prolonged period of follow-ups to clarify the effect of DM on brain dysfunction. Additionally, we also think that enhancing experimental reproducibility using animal models in conjunction with application of advanced devices should be considered when new experiments are designed. It is expected that further investigation of the underlying mechanisms of diabetic cognitive impairment will provide novel insights into therapeutic approaches for ameliorating diabetes-associated injury in the brain.

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Crucial players in Alzheimer’s disease and diabetes mellitus: Friends or foes?

Cited by 33 publications

References 147 publications

Chemodiversity and biological activity of essential oils from three species from the Euphorbia genus

Chemodiversity and biological activity of essential oils from three species from the Euphorbia genus

Role of Mesenchymal Stem Cells in Counteracting Oxidative Stress—Related Neurodegeneration

Potential Biochemical Mechanisms of Brain Injury in Diabetes Mellitus

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