2021
DOI: 10.1080/21655979.2021.1974645
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CRTAC1 (Cartilage acidic protein 1) inhibits cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process in bladder cancer by downregulating Yin Yang 1 (YY1) to inactivate the TGF-β pathway

Abstract: Cartilage acidic protein 1 (CRTAC1) is predicted to be aberrantly expressed in bladder cancer based on bioinformatics analysis. However, its functions and molecular mechanism in bladder cancer remain elusive. This study aimed to explore the role of CRTAC1 in bladder cancer. The mRNA and protein levels of CRTAC1 and Yin Yang 1 (YY1) were detected by reverse transcription quantitative polymerase chain reaction and western blotting. We found that CRTAC1 was downregulated in bladder cancer tissues and cells. Cell … Show more

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Cited by 19 publications
(16 citation statements)
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References 40 publications
(34 reference statements)
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“…Their downregulation in association with field effects signifies the aberrant differentiation program in bladder mucosa setting up the organ for basal cancer development. We also observed downregulation of MUC15 and CRTAC1 , both of which encode extracellular glycoprotein complexes but their role in urothelial biology is uncertain ( Steck et al., 2007 ; Yang et al., 2021 ; Yue et al., 2020 ; Zhang et al., 2020b ).…”
Section: Resultsmentioning
confidence: 70%
“…Their downregulation in association with field effects signifies the aberrant differentiation program in bladder mucosa setting up the organ for basal cancer development. We also observed downregulation of MUC15 and CRTAC1 , both of which encode extracellular glycoprotein complexes but their role in urothelial biology is uncertain ( Steck et al., 2007 ; Yang et al., 2021 ; Yue et al., 2020 ; Zhang et al., 2020b ).…”
Section: Resultsmentioning
confidence: 70%
“…Thus, it was decided to search for an appropriate target of this transcription factor to certify its anti-cancer characteristics specifically in BLCA. It turned out that CRTAC1 is of interest for bladder cancer since it inhibits many pro-tumorigenic processes including cell viability and migration [67]. To recapitulate, the decrease in both IL1A and MAP3K7 (during AP-2α overexpression) or only MAP3K7 (during WWOX overexpression) can further lead to an increase in TCF7L1, which affects metastasis and CRTAC1 expression.…”
Section: Discussionmentioning
confidence: 99%
“…The three candidate genes detected in this study were CRTAC1 , BATF2 , and CTHRC1 . Evidence shows that cartilage acidic protein 1 (CRTAC1) is related to various malignancies, including bladder cancer and lung adenocarcinoma, by inhibiting the cell proliferation, migration, invasion, and epithelial–mesenchymal transition processes ( Yang et al., 2021 ; Yu et al., 2021 ). However, the role of CRTAC1 has not yet been reported in STAD or other gastric cancer.…”
Section: Discussionmentioning
confidence: 99%