CRST Syndrome and Nodular Transformation of the Liver

Lurie, B.; Novis, B. H.; Bank, Simmy; Silber, William L.; Botha, J. B. C.; Marks, I. N.

doi:10.1016/s0016-5085(73)80170-2

Cited by 40 publications

(10 citation statements)

References 14 publications

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“…After the first report of NRHL associated with limited scleroderma was made in 1973, 57 the association of NRHL with limited scleroderma has been widely quoted, but only a handful of cases have been reported. Furthermore, a new clinical entity of limited scleroderma with NRHL and PBC has been proposed.…”

Section: Sclerodermamentioning

confidence: 99%

Hepatic manifestations of autoimmune rheumatic diseases

Abraham

Begum²,

Isenberg³

2004

Annals of the Rheumatic Diseases

176

107

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Section: Sclerodermamentioning

confidence: 99%

Hepatic manifestations of autoimmune rheumatic diseases

Abraham

Begum²,

Isenberg³

2004

Annals of the Rheumatic Diseases

176

107

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“…Unlike liver cirrhosis, there are no fibrous septa. Nodular regenerative hyperplasia is often complicated by portal hypertension and occurs with various syndromes, blood diseases, and immunological abnormalities in many cases, 7–12 but not in others.…”

Section: Conventional Classification Of Benign Nodular Hepatocellularmentioning

confidence: 99%

“…Nodular regenerative hyperplasia is known to occur with various syndromes, 8,9 immunological abnormalities, 12 thrombosis, 10 and vasculitis, 11 and these conditions have been considered to be involved in its etiology. However, their concurrence is unclear in some patients.…”

Section: Conventional Classification Of Benign Nodular Hepatocellularmentioning

confidence: 99%

Benign nodular hepatocellular lesions caused by abnormal hepatic circulation: Etiological analysis and introduction of a new concept¹

Kondo

2001

J of Gastro and Hepatol

177

143

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Problems in definitive diagnosis and etiology of various benign nodular hepatocellular lesions were evaluated. Of these lesions, focal nodular hyperplasia (FNH), nodular regenerative hyperplasia (NRH), nodular lesions associated with idiopathic portal hypertension (IPH), non‐cirrhotic large regenerative nodules (LRN), hepatocellular adenoma (HA)‐like hyperplastic nodules, and partial nodular transformation (PNT) have been suggested to be related to abnormal hepatic circulation. However, the following points are considered to need further clarification: (i) is the abnormal circulation caused by thrombosis, vasculitis, or congenital anomaly?; (ii) is thrombosis a cause or a result of congestion?; (iii) are impaired blood vessels primarily the portal veins or arteries?; (iv) how are these disorders related to various syndromes, immunological abnormalities and abnormal blood flow of other organs, which are reported to coexist with these lesions often?; and (v) how should non‐typical cases, which differ from typical cases, be interpreted? In addition, a concept that may lead to solving these problems (anomalous portal tract syndrome; a hypothesis that congenital vascular anomaly is the origin of these benign nodular hepatocellular lesions) was introduced.

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“…Nodular regenerative hyperplasia of the liver (NRHL) was first described in post-mortem material (Steiner, 1959), and subsequently in association with Felty's syndrome (Blendis et al, 1970), rheumatoid arthritis, congestive heart failure, CRST syndrome (Lurie et al, 1973), bacterial endocarditis (Knowles, Kaye and Goodman, 1975) and myelofibrosis (Shorey et al, 1979). Our patient had myxoedema associated with anti-smooth muscle antibodies.…”

Section: Discussionmentioning

confidence: 70%

An unusual cause of variceal haemorrhage in an elderly patient

Somerville¹,

Boyd²,

Ansell³

et al. 1984

Postgraduate Medical Journal

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SummaryAn elderly patient with nodular regenerative hyperplasia of the liver and hypothyroidism who presented with life-threatening bleeding from oesophageal varices is discussed. Progress has been uneventful following a semi-emergency portocaval shunt 5 years ago with no evidence of hepatic encephalopathy. This is presumably a tribute to the relatively wellpreserved hepatic function in this condition.KEY WORDS: nodular hyperplasia of liver, varices, portocaval shunt, hypothyroidism. IntroductionPortocaval anastomosis for bleeding varices is relatively contraindicated in the elderly because of the high postoperative mortality and the fear that the procedure will precipitate postoperative encephalopathy. We report an elderly patient who has done surprisingly well following such a procedure; presumably a result of well-preserved hepatic function in association with a rare liver disorder, nodular regenerative hyperplasia.

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CRST Syndrome and Nodular Transformation of the Liver

Cited by 40 publications

References 14 publications

Hepatic manifestations of autoimmune rheumatic diseases

Hepatic manifestations of autoimmune rheumatic diseases

Benign nodular hepatocellular lesions caused by abnormal hepatic circulation: Etiological analysis and introduction of a new concept¹

An unusual cause of variceal haemorrhage in an elderly patient

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CRST Syndrome and Nodular Transformation of the Liver

Cited by 40 publications

References 14 publications

Hepatic manifestations of autoimmune rheumatic diseases

Hepatic manifestations of autoimmune rheumatic diseases

Benign nodular hepatocellular lesions caused by abnormal hepatic circulation: Etiological analysis and introduction of a new concept1

An unusual cause of variceal haemorrhage in an elderly patient

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Benign nodular hepatocellular lesions caused by abnormal hepatic circulation: Etiological analysis and introduction of a new concept¹