CrRLK1L receptor-like kinases HERCULES RECEPTOR KINASE 1 and ANJEA are female determinants of pollen tube reception

Galindo-Trigo, Sergio; Blanco‐Touriñán, Noel; DeFalco, Thomas A.; Es, Wells; Gray, Julie E.; Zipfel, Cyril; Smith, Lee

doi:10.1101/428854

Cited by 16 publications

(40 citation statements)

References 61 publications

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“…We therefore next tested membrane targeting of ANX1-GFP and BUPS2-GFP and observed that these receptors have normal membrane localization even without LLG2/3 (Figure S5B). A similar localization at the synergid plasma membrane was recently reported for the CrRLK1Ls HERK1 and ANJEA [33]. Next, we investigated the interactions among LLG2/3, the BUPS-ANX receptor complex, and the peptide ligands RALF4/19.…”

Section: Llg2/3 Are Involved In Ralf4/19-mediated Signaling As Co-receptorssupporting

confidence: 70%

LLG2/3 Are Co-receptors in BUPS/ANX-RALF Signaling to Regulate Arabidopsis Pollen Tube Integrity

Zhao

Liu

et al. 2019

Current Biology

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In angiosperms, two sperm cells are transported and delivered by the pollen tube to the ovule to achieve double fertilization. Extensive communication takes place between the pollen tube and the female tissues until the sperm cell cargo is ultimately released. During this process, a pollen tube surface-located receptor complex composed of ANXUR1/2 (ANX1/2) and Buddha's Paper Seal 1/2 (BUPS1/2) was reported to control the maintenance of pollen tube integrity by perceiving the autocrine peptide ligands rapid alkalinization factor 4 and 19 (RALF4/19). It was further hypothesized that pollen-tube rupture to release sperm is caused by the paracrine RALF34 peptide from the ovule interfering with this signaling pathway. In this study, we identified two Arabidopsis pollen-tube-expressed glycosylphosphatidylinositol-anchored proteins (GPI-APs), LORELEI-like-GPI-anchored protein 2 (LLG2) and LLG3, as co-receptors in the BUPS-ANX receptor complex. llg2 llg3 double mutants exhibit severe fertility defects. Mutant pollen tubes rupture early during the pollination process. Furthermore, LLG2 and LLG3 interact with ectodomains of both BUPSs

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Section: Llg2/3 Are Involved In Ralf4/19-mediated Signaling As Co-receptorssupporting

confidence: 70%

LLG2/3 Are Co-receptors in BUPS/ANX-RALF Signaling to Regulate Arabidopsis Pollen Tube Integrity

Zhao

Liu

et al. 2019

Current Biology

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“…As pollen tubes approach ovules, ovule-expressed AtRALF34 peptide competes with pollen-expressed AtRALF4 and 19 for binding to ANX1/2 or BUPS1/2, allowing sperm cell discharge (Ge et al, 2017). Recently, two CrRLK1L receptor-like kinases, HERCULES1 (HERK1) and ANJEA (ANJ), were identified as female determinants of pollen tube reception (Galindo-Trigo et al, 2019). Both HERK1 and ANJ interact with FER and, although not yet proved, an analogous mechanism was proposed where pollen-derived RALFs would act upon receptor heterocomplexes made of FER, HERK1 and ANJ assembled on female tissues to control pollen tube reception (Galindo-Trigo et al, 2019).…”

Section: Regulation Of Cell Physiology Growth and Developmental Procmentioning

confidence: 99%

“…Recently, two CrRLK1L receptor-like kinases, HERCULES1 (HERK1) and ANJEA (ANJ), were identified as female determinants of pollen tube reception (Galindo-Trigo et al, 2019). Both HERK1 and ANJ interact with FER and, although not yet proved, an analogous mechanism was proposed where pollen-derived RALFs would act upon receptor heterocomplexes made of FER, HERK1 and ANJ assembled on female tissues to control pollen tube reception (Galindo-Trigo et al, 2019). Fertilization is the result of an interplay between signal molecules, their receptors, second messengers and cell wall components.…”

Section: Regulation Of Cell Physiology Growth and Developmental Procmentioning

confidence: 99%

Twenty Years of Progress in Physiological and Biochemical Investigation of RALF Peptides

2020

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RALF isoforms play many biological roles and their specific functions are defined by combinatorial interactions with dynamic receptor complexes that vary more than initially thought. Author contributions: All authors participated in writing the Update. KEYWORDS: Rapid Alkalinization Factor (RALF), Carantheus roseus Receptor Like Kinase 1 Like (CrRLK1L), FERONIA (FER), THESEUS1 (THE1), ANXUR1/2 (ANX1/2), BUDDHA'S PAPER SEAL (BUPS), HERCULES1 (HERK1) A family of secreted peptides known as the RALFs (Rapid ALkalinization Factors) induce rapid alkalinization of the extracellular compartment of plant cells. RALFs are perceived by a family of Carantheus roseus Receptor Like Kinase 1 Like proteins (CrRLK1Ls), a structurally related family of plasma membrane-enriched receptors. RALF perception coincides with the downregulation of plasma membrane H +-ATPase function, which reduces energy for solute uptake and results in growth inhibition. In this review, we discuss the initial discovery of this ubiquitous family of peptide growth regulators and their cognate receptors. We describe recent detailed structural studies of RALF-CrRLK1Ls interactions and the identification of a subset of downstream signaling components. We then summarize the current state of RALFs-CrRLK1L research with emphasis on the Arabidopsis (Arabidopsis thaliana) RALFs (AtRALFs) and their roles in cellular regulation of plant growth and development, and in biotic and abiotic stress responses. RALF DISCOVERY, STRUCTURE AND DIVERSITY The origins of the RALF field lie in the work of Clarence "Bud" Ryan's group at Washington State University, with the discovery of the first RALF peptide using an activity assay originally designed to detect systemins, which are small, ~18 amino acid peptide hormones involved in the wound-response, in tobacco (Nicotiana tabacum) plants. This assay targeted the alkalinization caused by systemins and was used to test HPLC-fractionated tobacco leaf extracts. Surprisingly, an HPLC fraction eluting later than systemins elicited an unexpectedly fast and prominent increase in the pH of the culture medium. Edman degradation later confirmed that this activity

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“…Other malectin-like RLKs involved in plant reproduction are HERCULES RECEPTOR KINASE 1 (HERK1) and ANJEA (ANJ). During fertilization, HERK1 and ANJ interact with FER to regulate pollen tube reception (Galindo-Trigo et al, 2020). Additionally, malectinlike RLKs BUDDHA'S PAPER SEAL 1/2 (BUPS1/2) and ANX1/2 were reported to play a role in plant reproduction by controlling the pollen tube's cell wall integrity during fertilization (Boisson-Dernier et al, 2009;Miyazaki et al, 2009;Ge et al, 2017).…”

Section: Rlks and Rlps With Distinct Extracellular Domains In Plant Gmentioning

confidence: 99%

“…Meanwhile, the MAPK cascade downstream of chitin and CERK1 pathway consists of MEKK‐MKK4/MKK5‐MPK3/MPK6 (Miya et al, 2007; Meng and Zhang, 2013). Likewise, plant response to DAMPs leads to activation of WAK receptors that will transduce the signal through the MPK3/MPK6 cascade (Denoux et al, 2008; Galletti et al, 2011; Meng and Zhang, 2013). MAPK activation often leads to the expression of immune‐related genes, ROS production, stomatal closure, ethylene production, and hypersensitive response (Meng and Zhang, 2013).…”

Section: Intracellular Signaling Upon Activation Of Rlk Rlp and Rlck Complexesmentioning

confidence: 99%

Plant plasma membrane‐resident receptors: Surveillance for infections and coordination for growth and development

Manhães

Ortiz-Morea

et al. 2021

JIPB

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As sessile organisms, plants are exposed to pathogen invasions and environmental fluctuations. To overcome the challenges of their surroundings, plants acquire the potential to sense endogenous and exogenous cues, resulting in their adaptability. Hence, plants have evolved a large collection of plasma membrane-resident receptors, including RECEPTOR-LIKE KINASEs (RLKs) and RECEPTOR-LIKE PROTEINs (RLPs) to perceive those signals and regulate plant growth, development, and immunity. The ability of RLKs and RLPs to recognize distinct ligands relies on diverse categories of extracellular domains evolved. Co-regulatory receptors are often required to associate with RLKs and RLPs to facilitate cellular signal transduction. RECEPTOR-LIKE CYTOPLASMIC KINASEs (RLCKs) also associate with the complex, bifurcating the signal to key signaling hubs, such as MITOGEN-ACTIVATED PROTEIN KINASE (MAPK) cascades, to regulate diverse biological processes. Here, we discuss recent knowledge advances in understanding the roles of RLKs and RLPs in plant growth, development, and immunity, and their connection with co-regulatory receptors, leading to activation of diverse intracellular signaling pathways.

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CrRLK1L receptor-like kinases HERCULES RECEPTOR KINASE 1 and ANJEA are female determinants of pollen tube reception

Cited by 16 publications

References 61 publications

LLG2/3 Are Co-receptors in BUPS/ANX-RALF Signaling to Regulate Arabidopsis Pollen Tube Integrity

LLG2/3 Are Co-receptors in BUPS/ANX-RALF Signaling to Regulate Arabidopsis Pollen Tube Integrity

Twenty Years of Progress in Physiological and Biochemical Investigation of RALF Peptides

Plant plasma membrane‐resident receptors: Surveillance for infections and coordination for growth and development

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