CRP levels in extremely low birth weight (ELBW) septic infants

Abstract

Highest CRP values in <1000 g infants increase in levels comparable to full terms, but with a 24-h delay.

Markedly raised levels of C‐reactive protein are associated with culture‐proven sepsis or necrotising enterocolitis in extremely preterm neonates

“…Previous research has described a lesser CRP response in CoNS neonatal infections, generally compared to S. aureus , GBS, E. coli and Candida spp. infections . While this may be the case when investigating all the neonatal infections in which these organisms were identified, our data demonstrate that CoNS is able to elicit a marked CRP response, as this was the most commonly identified organism in our sample of neonates with CRP >100 mg/L.…”

C-reactive protein for late-onset sepsis diagnosis in very low birth weight infants

“…Previous studies concluded that CoNS might induce a less sustained inflammatory response than gram-negative bacterial sepsis [ 13 , 14 ]. However, our findings do not suggest a statistically significant difference in peak CRP’s values in infants with CoNS compared to other pathogens, however this is not statistically significant given the small number of gram-negative infections.…”

“…Many studies have assessed the use of CRP for the diagnosis of early-onset sepsis in term and late-preterm infants [ 13 – 15 ]. In these populations, two CRP values of < 10 mg/L have a negative predictive value of 93 to 97% [ 2 , 12 , 16 , 17 ].…”

C-Reactive Protein and Procalcitonin Diagnostic Value in Congenital Infection in Newborns with Extremely Low and Very Low Birth Weight

“…В своем исследовании авторы впервые показали, что чем меньше гестационный возраст ребенка и меньше масса тела при рождении, тем менее выражено повышение СРБ [13]. По мнению Dritsakou и соавт., СРБ не является корректным диагностическим тестом при диагностике сепсиса у новорожденных с ЭНМТ и ОНМТ в связи с недостаточной реактивностью печени у глубоконедоношенных детей вследствие ее незрелости, в отличие от более зрелых недоношенных и доношенных новорожденных [14].…”