CRP Albumin Ratio May Predict No Reflow in Patients Undergoing Percutaneous Coronary Intervention for Saphenous Vein Graft Stenosis

Abstract

Many hypotheses have been proposed to explain no-reflow (NR). Some of these hypotheses, state that NR may be caused by damage to the vascular endothelium and an inflammatory process. In a recent study that did not include patients with coronary artery bypass graft (CABG), the ratio of C-reactive protein (CRP) to albumin (CAR) was found to be associated with NR. Our study aims to evaluate the relationship between CAR and NR in patients who underwent percutaneous coronary intervention (PCI) for saphenous vein graft (SVG). In this retrospective study, among the patients with CABG who underwent primary or elective coronary angiography, 242 patients who underwent PCI to the SVG were selected. The incidence of NR was 19.8% (n = 48). Diabetes mellitus, left ventricular ejection fraction (LVEF), stent length, and CAR were found as independent predictors of NR in multivariate logistic regression analysis (P < .05). Using a cut-off level of .930, the CAR predicted NR with a sensitivity of 75% and a specificity of 73% (AUC: .814, 95% CI: .749–.879, P < .001). The CAR was a better predictor than both stent length and LVEF. CAR was found to be the strongest predictor of NR in our study.

Relationship Between High Sensitivity C-reactive Protein to Albumin Ratio With Infarct-related Artery Patency in Patients With Non-ST-segment Elevation Myocardial Infarction

“…24 In a recent study, Kanal et al reported that CAR was an independent predictor of the no-reflow phenomenon in patients undergoing saphenous vein graft PCI. 25 In patients with NSTEMI, complete occlusion of the responsible coronary artery is not uncommon. A study found that 22.4% of patients with NSTEMI had complete occlusion of the responsible artery.…”

“…24 In a recent study, Kanal et al reported that CAR was an independent predictor of the no-reflow phenomenon in patients undergoing saphenous vein graft PCI. 25…”

Impact of HAT2CH2 Score on the Development of No-Reflow Phenomenon in Patients With ST-Segment Elevation Myocardial Infarction

“…It should be noted, nonetheless, that a wide variety of demographic, laboratory, and procedural factors have been proven to influence the development of NR. [20][21][22][23][24] Several studies have shown a link between AF-related stroke risk scoring systems, which are often used in cardiology, and NR in acute MI patients. Independent of AF and stroke risks, the impact of stroke risk scoring system components on coronary artery events was also examined.…”

“…It should be noted, nonetheless, that a wide variety of demographic, laboratory, and procedural factors have been proven to influence the development of NR. 20–24…”