“…In main chain polyrotaxanes, the macrocycle is threaded on the polymeric backbone, and the dissociation of the constituents is prevented by bulky groups, which are attached at the chain ends or randomly along the chain. , Side chain polyrotaxanes possess rotaxanated units that are positioned at side groups of the polymer . Threading of macrocycles onto the polymer chains is a noncovalent modification of the macromolecules that affects the properties, such as solubility and reactivity as well as the mechanical, electrical, and processing properties. ,− The solubility of a polymer can be enhanced by polyrotaxane formation due to the shielding effect exerted by the threaded rings, preventing molecular interactions between the polymer chains, such as hydrophobic or π–π interactions. − Polyrotaxanes can also be cross-linked through reactive functionalities on the macrocycles, resulting in so-called slide ring gels that may exhibit self-healing properties, high degrees of swelling, and elongations at break due to the movable cross-links. − Among crown ethers, − cucurbiturils, − calixarenes, and cyclodextrins (CDs), , CDs are the most commonly used class of cyclic molecules in polyrotaxane synthesis because CDs are nontoxic, biodegradable, available on the industrial scale, and easily functionalizable. , However, the large-scale synthesis of polyrotaxanes remains challenging despite the many polyrotaxanes that have been previously reported in the literature. The so-called threading approach, which is most commonly used for polyrotaxane synthesis, involves threading the macrocycle onto a given polymer followed by attachment of stopper groups.…”