Crowdsourcing and open innovation in drug discovery: recent contributions and future directions

Thompson, David C.; Bentzien, Jörg

doi:10.1016/j.drudis.2020.09.020

Cited by 16 publications

(9 citation statements)

References 55 publications

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“…Major players worldwide have tilted toward collaborative and open innovation models, where multiple organizations share data and resources toward a common goal, a practice that has progressively gained adherents in the drug discovery sector [45,46] but certainly grew in the present scenario. These initiatives could help to overcome the usual barriers for the realization of drug repurposing.…”

Section: Intellectual and Commercial Barriers And Collaborative Modelsmentioning

confidence: 99%

Can drug repurposing strategies be the solution to the COVID-19 crisis?

Bellera

Llanos

Gantner

et al. 2020

Expert Opinion on Drug Discovery

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Introduction:The COVID-19 pandemic resulted in disastrous human and economic costs, mainly due to the initial lack of specific treatments. Complementary to immunotherapies, drug repurposing is possibly the best option to arrive at COVID-19 treatments in the short term. Areas covered: Repurposing prospects undergoing clinical trials or with some level of evidence emerging from clinical studies are overviewed. The authors discuss some possible intellectual property and commercial barriers to drug repurposing, and strategies to facilitate equitable access to incoming therapeutic solutions, highlighting the importance of collaborative drug discovery models. Based on a critical analysis of the available literature about in silico screens against SARS-CoV-2 main protease, the authors illustrate how frequently overconfident conclusions are being drawn in COVID-19-related literature. Expert opinion: Most of the current clinical trials on potential COVID-19 treatments are, in fact, drug repurposing examples. In October 2020, the FDA approved a repurposed antiviral, remdesivir, as the first treatment for COVID-19. Considering the high expectations invested in approaching therapeutic solutions, the scientific community must be careful not to raise unrealistic expectations. Today more than ever, the conclusions drawn in scientific reports have to be fully supported by the level of evidence, avoiding any sort of unfounded speculation.

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Section: Intellectual and Commercial Barriers And Collaborative Modelsmentioning

confidence: 99%

Can drug repurposing strategies be the solution to the COVID-19 crisis?

Bellera

Llanos

Gantner

et al. 2020

Expert Opinion on Drug Discovery

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“…However, companies no longer need to launch their own crowdsourcing or open-source platforms because there are several commonly used platforms, such as Kaggle, InnoCentive, and DREAM, that can facilitate the interaction with the crowd. 37 Nevertheless, our analysis aimed to identify companies that leverage crowd-based OI models to a significant extent and, thus, incorporate them actively in their OI strategy.…”

Section: Open Innovation Models In Pharmaceutical Randdmentioning

confidence: 99%

Open innovation: A paradigm shift in pharma R&D?

Schuhmacher

Gassmann

Bieniok

et al. 2022

Drug Discovery Today

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“…The above, considering that the digital age offers a great opportunity for companies to access new knowledge for innovation processes (de Mattos, Kissimoto, & Laurindo, 2018; Han, Sun, Song, Fang, & Liu, 2021;Ruiz et al, 2020). Specifically, in the last decade the use of crowdsourcing and open innovation approaches has increased to involve different actors in solving problems or in developing projects (Acar, 2019;Ruiz et al, 2020;Thompson & Bentzien, 2020). Indeed, previous studies (Vignieri, 2020) define crowdsourcing as a mode of open innovation, in the context of the collaborative economy.…”

Section: Crowdsourcingmentioning

confidence: 99%

Open Collaboration and Digital Technologies in the Context of Environmental Innovations

Miranda¹,

Pertuz²,

Cázares³

et al. 2021

Business With a Conscience

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Digital technologies are a valuable strategy for finding, identifying, combining and integrating external knowledge, as well as for generating new organizational forms to develop innovative solutions. At the same time, digital technologies are allowing a more active collaboration and interaction among companies, communities of experts, and consumers in order to address environmental-oriented innovation challenges. Environmental innovation refers to the development of new or improved products and the creation of new processes and business models that bring benefits to the natural environment. In that sense, the main objective of this study is to discuss, from a conceptual perspective, how digital technologies promote open collaboration processes to achieve environmental innovations.We analyze crowdsourcing, customer co-development, and R&D alliances as mechanisms to achieve Sustainable Development Goals in general, and environmental-oriented innovations in particular. Our study expands the argument that collaboration with outsiders is a key capability to advance towards environmental innovation and to acquire and provide unique resources and knowledge to facilitate the environmental innovation process.

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Crowdsourcing and open innovation in drug discovery: recent contributions and future directions

Abstract: Highlights Recent use and future directions of Crowdsourcing and Open Innovation in drug discovery are presented. Pharmaceutical companies’ online presentation of their own engagement and use of Open Innovation is assessed and compared.

Cited by 16 publications

References 55 publications

Can drug repurposing strategies be the solution to the COVID-19 crisis?

Can drug repurposing strategies be the solution to the COVID-19 crisis?

Open innovation: A paradigm shift in pharma R&D?

Open Collaboration and Digital Technologies in the Context of Environmental Innovations

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