Crotapotin induced modification of T lymphocyte proliferative response through interference with PGE2 synthesis

Garcia, Flávia; Toyama, Marcos H.; Castro, Fabiano R.; Proença, Patricia L.F.; Marangoni, Sérgio; Santos, Leonilda Maria Barbosa dos

doi:10.1016/s0041-0101(03)00198-3

Cited by 25 publications

(23 citation statements)

References 19 publications

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“…The venom components responsible for the hepatotoxicity are still undetermined, but they probably involve PLA 2 action on cell membrane lipids and mitochondrial respiration (38), as well as various cell types such as lymphocytes (41,42), macrophages (39,40,43,44), mast cells (45), and platelets (3,(46)(47)(48)(49). In support of Coagulation disturbances (19,20) leading to fibrin deposition and ischemia, mainly through the action of the thrombin-like enzyme (gyroxin) of this venom (8,9,19) could also contribute to the hepatic damage registered in the present study.…”

Section: Discussionmentioning

confidence: 99%

Acute hepatotoxicity of Crotalus durissus terrificus (South American rattlesnake) venom in rats

França¹,

Ferrari²,

Souza³

et al. 2009

J. Venom. Anim. Toxins incl. Trop. Dis

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Venom of the South American rattlesnake, Crotalus durissus terrificus (Cdt), presents myotoxic and neurotoxic outcomes, but reports on its effects on the liver are scarce. This study examined the hepatotoxicity resulting from Cdt venom administration (100, 200 and 300 μg/kg) in male Wistar rats. Animals were studies at 3, 6, 9 and 12 hours after venom injection. The hepatotoxicity was assessed through serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AP), gamma glutamyl transferase (GGT), bilirrubin and also by histopathological evaluation. All the different concentrations of Cdt venom resulted in increased levels of hepatic enzymes, when compared with the control group, except for the 100 μg/kg dose, which presented normal levels at 9 and 12 hours after venom administration. Bilirrubin levels remained unchanged by Cdt venom. Histological analysis revealed endothelial damage, inflammatory cell infiltration, as well as sinusoidal and portal congestion. Based on these observations, we may conclude that Cdt venom causes dose-and time-dependent hepatic damage in rats, characterized by elevated hepatic enzyme levels and histological alterations.

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Section: Discussionmentioning

confidence: 99%

Acute hepatotoxicity of Crotalus durissus terrificus (South American rattlesnake) venom in rats

França¹,

Ferrari²,

Souza³

et al. 2009

J. Venom. Anim. Toxins incl. Trop. Dis

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“…The addition of indomethacin to the lymphocyte culture abrogated the suppressive effect caused by crotapotin, thus implicating the participation of COX derivatives in this suppression. This hypothesis was corroborated by increased amounts of PGE 2 measured in the supernatant of lymphocytes and purified macrophages cultures [223]. Together, these data infer that crotapotin activates the innate immune response and the cytokines and eicosanoids produced by this activation may modify the subsequent adaptative immune reaction.…”

Section: Crotalus Genusmentioning

confidence: 62%

“…Crotapotin, seems to have anti-inflammatory and antiproliferative activities, as seen in the in vivo inhibition of carrageenin-induced rat paw oedema [222], as well as by means of suppressing lymphocyte transformation in vitro [223]. The addition of indomethacin to the lymphocyte culture abrogated the suppressive effect caused by crotapotin, thus implicating the participation of COX derivatives in this suppression.…”

Section: Crotalus Genusmentioning

confidence: 91%

Pro and Antiinflammatory Properties of Toxins from Animal Venoms

Farsky

Antunes²,

Mello³

2005

CDTIA

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Accidents evoked by venomous animals are common in tropical regions. In Brazil, envenomation evoked by snakes, spiders and scorpions are an important public health problem. Their venoms are composed of a great number of toxins, which are capable of acting on tissue and plasma components with consequent toxic and pharmacological effects. On the other hand, the diversity of venom composition makes them important source of toxins that can be employed as scientific tools. Here we describe the mechanisms of anti and pro-inflammatory properties of toxins of Bothrops and Crotalus genus snakes and Loxosceles and Phoneutria genus spider venoms. The emphasis was to summarise, both in vivo and in vitro, studies that focused on the action of phospholipases, metalloproteinases and sphingomyelinase D on vascular and cellular aspects of the process as well as the complex network of chemical mediators involved.

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“…CARDOSO E MOTA, 1997; DA SILVA; SAMPAIO; GONÇALVES, 2013;GARCIA et al, 2003;FAVORETTO et al, 2011;LANDUCCI et al, 1995;SOUSA-E-SILVA et al, 1996;SAMPAIO et al, 2010).…”

Section: Características Gerais Da Crotoxina Do Veneno De Crotalus Duunclassified

Estudo da imunomodulação induzida pela crotoxina do veneno de Crotalus durissus terrificus em modelo experimental de doença inflamatória no intestino.

Almeida¹

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Crotapotin induced modification of T lymphocyte proliferative response through interference with PGE2 synthesis

Cited by 25 publications

References 19 publications

Acute hepatotoxicity of Crotalus durissus terrificus (South American rattlesnake) venom in rats

Acute hepatotoxicity of Crotalus durissus terrificus (South American rattlesnake) venom in rats

Pro and Antiinflammatory Properties of Toxins from Animal Venoms

Estudo da imunomodulação induzida pela crotoxina do veneno de Crotalus durissus terrificus em modelo experimental de doença inflamatória no intestino.

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