Crosstalk of regulatory T cells and tolerogenic dendritic cells prevents contact allergy in subjects with low zone tolerance

Luckey, Ulrike; Schmidt, Talkea; Pfender, Nikolai; Romer, Maike; Lorenz, Nina; Martin, Stefan F.; Bopp, Tobias; Schmitt, Edgar; Nikolaev, A.; Yogev, Nir; Waisman, Ari; Jakob, Thilo; Steinbrink, Kerstin

doi:10.1016/j.jaci.2012.06.022

Cited by 40 publications

(36 citation statements)

References 55 publications

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“…Modulation of immune responses using “educated” immune cells was recently used to prevent allergy reactions in mice. This effect was based on the generation of tolerogenic DCs after gap junctional communication with Tregs [249]. Another recent study showed that Tregs through GJCs are involved in controlling the HIV replication in T cells [250], opening an unexplored way to modulate the HIV infection.…”

Section: Discussionmentioning

confidence: 99%

Regulation of Hemichannels and Gap Junction Channels by Cytokines in Antigen-Presenting Cells

Saéz

Shoji

Aguirre

et al. 2014

Mediators of Inflammation

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Autocrine and paracrine signals coordinate responses of several cell types of the immune system that provide efficient protection against different challenges. Antigen-presenting cells (APCs) coordinate activation of this system via homocellular and heterocellular interactions. Cytokines constitute chemical intercellular signals among immune cells and might promote pro- or anti-inflammatory effects. During the last two decades, two membrane pathways for intercellular communication have been demonstrated in cells of the immune system. They are called hemichannels (HCs) and gap junction channels (GJCs) and provide new insights into the mechanisms of the orchestrated response of immune cells. GJCs and HCs are permeable to ions and small molecules, including signaling molecules. The direct intercellular transfer between contacting cells can be mediated by GJCs, whereas the release to or uptake from the extracellular milieu can be mediated by HCs. GJCs and HCs can be constituted by two protein families: connexins (Cxs) or pannexins (Panxs), which are present in almost all APCs, being Cx43 and Panx1 the most ubiquitous members of each protein family. In this review, we focus on the effects of different cytokines on the intercellular communication mediated by HCs and GJCs in APCs and their impact on purinergic signaling.

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Section: Discussionmentioning

confidence: 99%

Regulation of Hemichannels and Gap Junction Channels by Cytokines in Antigen-Presenting Cells

Saéz

Shoji

Aguirre

et al. 2014

Mediators of Inflammation

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“…Development of tolerogenic DC phenotype may be of importance for prevention of allergic contact dermatitis. Activated IL-10(+) Treg cells might induce production of the tolerogenic CD11c(+) DCs, and leads to the generation of hapten-specific CD8(+) Treg cells, which protect against contact hypersensitivity [38]. …”

Section: Introductionmentioning

confidence: 99%

Subsets of regulatory T cells and their roles in allergy

et al. 2014

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In recent years, it is recognized that acquired immunity is controlled by regulatory T cell (Treg). Since fundamental pathophysiological changes of allergy are mainly caused by hyperresponsiveness of immune system to allergens that acquires after birth, Tregs likely play key roles in the pathogenesis of allergy, particularly during the sensitization phase. However, accumulated information indicate that there are several distinctive subtypes of Tregs in man, and each of them seems to play different role in controlling immune system, which complicates the involvement of Tregs in allergy. The aim of the present study is to attempt to classify subtypes of Tregs and summarize their roles in allergy. Tregs should include natural Tregs (nTreg) including inducible costimulator (ICOS)(+) Tregs, inducible/adaptive Tregs (iTreg), interleukin (IL)-10-producing type 1 Tregs (Tr1 cells), CD8(+) Tregs and IL-17-producing Tregs. These cells share some common features including expression of Foxp3 (except for Tr1 cells), and secretion of inhibitory cytokine IL-10 and/or TGF-β. Furthermore, it is noticeable that Tregs likely contribute to allergic disorders such as dermatitis and airway inflammation, and play a crucial role in the treatment of allergy through their actions on suppression of effector T cells and inhibition of activation of mast cells and basophils. Modulation of functions of Tregs may provide a novel strategy to prevent and treat allergic diseases.

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“…Another type of cellular cross-talk between Tregs and DCs has been recently demonstrated in the murine model of contact hypersensitivity (138). Here Tregs conditioned DCs to induce regulatory CD8 + T cells that could protect against the disease (138).…”

Section: Interactions Between Tdcs and Immune Or Stromal Cells For Tomentioning

confidence: 95%

Self-Antigen Presentation by Dendritic Cells in Autoimmunity

2014

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The operation of both central and peripheral tolerance ensures the prevention of autoimmune diseases. The maintenance of peripheral tolerance requires self-antigen presentation by professional antigen presenting cells (APCs). Dendritic cells (DCs) are considered as major APCs involved in this process. The current review discusses the role of DCs in autoimmune diseases, the various factors involved in the induction and maintenance of tolerogenic DC phenotype, and pinpoints their therapeutic capacity as well as potential novel targets for future clinical studies.

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Crosstalk of regulatory T cells and tolerogenic dendritic cells prevents contact allergy in subjects with low zone tolerance

Cited by 40 publications

References 55 publications

Regulation of Hemichannels and Gap Junction Channels by Cytokines in Antigen-Presenting Cells

Regulation of Hemichannels and Gap Junction Channels by Cytokines in Antigen-Presenting Cells

Subsets of regulatory T cells and their roles in allergy

Self-Antigen Presentation by Dendritic Cells in Autoimmunity

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