Crosstalk of oxidative stress, inflammation, apoptosis, and autophagy under reactive oxygen stress involved in difenoconazole-induced kidney damage in carp

Wu, Xinyu; Xu, Baoshi; Chen, Huizhen; Qiang, Jingchao; Feng, Huimiao; Li, Xueqing; Chu, Mingyi; Pan, Enzhuang; Dong, Jingquan

doi:10.1016/j.fsi.2022.108508

Cited by 18 publications

(5 citation statements)

References 43 publications

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“…Thus, CPF promoted autophagy, oxidative damage, and apoptosis in the experimental fishes more than the control fish group (Zhang et al, 2019). Zhao et al (2021) found that CPF exposure in largemouth bass (Micropterus salmoides) caused an increase in IL-8, TNF-α, and IL-15 and a decrease in TGF-β1 and IL- According to Wu et al (2023), using the product led to an increase in BAX, p53, Caspase-3, and 9. Meanwhile, the BCL-2, Capsase-8, and FAS were inhibited.…”

Section: Pathways Involved In Pesticide-mediated Oxidative Damagementioning

confidence: 97%

“…Amidst the diversified range of fungicides available, difenoconazole is generally used triazole fungicide in the production of agricultural crops. In carp, difenoconazole exposure might cause ROS production resulting in oxidative stress with increased MDA levels and subsequent decline in the activity level of enzymatic antioxidants such as CAT, SOD, and GPx ( Wu et al, 2023 ). Nataraj et al (2023) studied the effects of difenoconazole exposure in Labeo rohita.…”

Section: Pesticides Induced Oxidative Stress In Fishesmentioning

confidence: 99%

“…TNF-α, Il-6, Il-1β, and iNOS were increased with the use of difenoconazole fungicide, while the transcription level of TGF-β1 and Il-10 was inhibited. According to Wu et al (2023) , using the product led to an increase in BAX, p53, Caspase-3, and 9. Meanwhile, the BCL-2, Capsase-8, and FAS were inhibited.…”

Section: Pesticides Induced Oxidative Stress In Fishesmentioning

confidence: 99%

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Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Subaramaniyam,

Allimuthu,

Vappu

et al. 2023

Front. Physiol.

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Microplastics and pesticides are emerging contaminants in the marine biota, which cause many harmful effects on aquatic organisms, especially on fish. Fish is a staple and affordable food source, rich in animal protein, along with various vitamins, essential amino acids, and minerals. Exposure of fish to microplastics, pesticides, and various nanoparticles generates ROS and induces oxidative stress, inflammation, immunotoxicity, genotoxicity, and DNA damage and alters gut microbiota, thus reducing the growth and quality of fish. Changes in fish behavioral patterns, swimming, and feeding habits were also observed under exposures to the above contaminants. These contaminants also affect the Nrf-2, JNK, ERK, NF-κB, and MAPK signaling pathways. And Nrf2-KEAP1 signalling modulates redox status marinating enzymes in fish. Effects of pesticides, microplastics, and nanoparticles found to modulate many antioxidant enzymes, including superoxide dismutase, catalase, and glutathione system. So, to protect fish health from stress, the contribution of nano-technology or nano-formulations was researched. A decrease in fish nutritional quality and population significantly impacts on the human diet, influencing traditions and economics worldwide. On the other hand, traces of microplastics and pesticides in the habitat water can enter humans by consuming contaminated fish which may result in serious health hazards. This review summarizes the oxidative stress caused due to microplastics, pesticides and nano-particle contamination or exposure in fish habitat water and their impact on human health. As a rescue mechanism, the use of nano-technology in the management of fish health and disease was discussed.

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Section: Pathways Involved In Pesticide-mediated Oxidative Damagementioning

confidence: 97%

Section: Pesticides Induced Oxidative Stress In Fishesmentioning

confidence: 99%

Section: Pesticides Induced Oxidative Stress In Fishesmentioning

confidence: 99%

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Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Subaramaniyam,

Allimuthu,

Vappu

et al. 2023

Front. Physiol.

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“…19 Previous studies have shown that oxidative stress can damage intestinal and renal functions and threaten the health of aquatic animals. 20,21 MDA is a typical marker of oxidative stress. 22 In this study, MDA contents in the gut and kidney were significantly higher when Cu concentration was at and above 513 μg/L, indicating the occurrence of oxidative stress in these tissues.…”

Section: Discussionmentioning

confidence: 99%

Copper toxicity in juvenile largemouth bass (Micropterus salmoides): acute toxicity bioassay and oxidative stress response in gut and kidney

Zhang,

Zhao,

Meng

et al. 2024

Israeli Journal of Aquaculture - Bamidgeh

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Aquaculture intensification has resulted in serious disease outbreaks in largemouth bass production. Compounds containing copper (Cu) are widely used as therapeutic agents in aquaculture. Currently, Cu misuse has been a severe issue in largemouth bass farming. However, few investigations have been performed on Cu toxicity in largemouth bass so far. In this study, an acute and a chronic toxicity test was carried out to determine the toxicity and the recommended dose of waterborne Cu in largemouth bass. In the acute toxicity bioassay, fish (2.58 ± 0.03 g) were exposed to 0 (control), 3, 6, 9, 18, or 30 mg/L Cu, and the results showed that the 96-h LC50 of waterborne Cu was 12.78 mg/L. Then a 30-day chronic toxicity test containing six treatments (i.e., 0, 51.3, 164, 513, 1640, and 5130 μg/L Cu) was conducted to investigate the influence of Cu on intestinal and renal health in terms of oxidative stress in juvenile largemouth bass (2.69 ± 0.02 g). The results showed that Cu concentrations at and above 51.3 μg/L significantly increased the malondialdehyde contents (in the intestine) and simultaneously decreased total superoxide dismutase activity levels (in the intestine and kidney), glutathione peroxidase activity levels (in the kidney), and reduced glutathione contents (in the kidney), compared to control. In contrast to control, fish exposed to high Cu concentrations (at and above 1640 μg/L) demonstrated lower catalase activity levels in the intestine and kidney. Based on the findings in the study, waterborne Cu content for largemouth bass farming was recommended to be less than 51.3 μg/L.

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“…Xinyu Wu et al [35] reported that DFZ exposure can induce apoptosis in the kidney in carp and Jiansheng Zhu et al [21] demonstrated that DFZ exposure triggers cardiovascular apoptosis in zebrafish. Given the reduction of spermatogenic epithelial cells in testicular tissue after DFZ exposure, we conjectured that DFZ exposure could induce apoptosis in mouse testis.…”

Section: Discussionmentioning

confidence: 99%

Difenoconazole Exposure Induces Retinoic Acid Signaling Dysregulation and Testicular Injury in Mice Testes

Zheng¹,

Ya²,

Chen³

et al. 2023

Toxics

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Difenoconazole (DFZ) is a broad-spectrum triazole fungicide that is widely utilized in agriculture. Although DFZ has been demonstrated to induce reproductive toxicity in aquatic species, its toxic effects on the mammalian reproductive system have yet to be fully elucidated. In vivo, male mice were administered 0, 20 or 40 mg/kg/d of DFZ via oral gavage for 35 days. Consequently, DFZ significantly decreased testicular organ coefficient, sperm count and testosterone levels, augmented sperm malformation rates, and elicited histopathological alterations in testes. TUNEL assay showed increased apoptosis in testis. Western blotting results suggested abnormally high expression of the sperm meiosis-associated proteins STRA8 and SCP3. The concentrations of retinoic acid (RA), retinaldehyde (RE), and retinol (ROL) were increased in the testicular tissues of DFZ-treated groups. The mRNA expression level of genes implicated in RA synthesis significantly increased while genes involved in RA catabolism significantly decreased. In vitro, DFZ reduced cell viability and increased RA, RE, and ROL levels in GC-2 cells. Transcriptome analysis revealed a significant enrichment of numerous terms associated with the RA pathway and apoptosis. The qPCR experiment verified the transcriptome results. In conclusion, our results indicate that DFZ exposure can disrupt RA signaling pathway, homeostasis, and induce testicular injury in mice testes.

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Crosstalk of oxidative stress, inflammation, apoptosis, and autophagy under reactive oxygen stress involved in difenoconazole-induced kidney damage in carp

Cited by 18 publications

References 43 publications

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Copper toxicity in juvenile largemouth bass (Micropterus salmoides): acute toxicity bioassay and oxidative stress response in gut and kidney

Difenoconazole Exposure Induces Retinoic Acid Signaling Dysregulation and Testicular Injury in Mice Testes

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