Crosstalk of methylation and tamoxifen in breast cancer (Review)
Jin Shen,
Yan He,
Shengpeng Li
et al.
Abstract:Tamoxifen is a widely used anti-estrogen drug in the endocrine therapy of breast cancer (BC). It blocks estrogen signaling by competitively binding to estrogen receptor α (ERα), thereby inhibiting the growth of BC cells. However, with the long-term application of tamoxifen, a subset of patients with BC have shown resistance to tamoxifen, which leads to low overall survival and progression-free survival. The molecular mechanism of resistance is mainly due to downregulation of ERα expression and abnormal activat… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.