Crosstalk between transforming growth factor-β signaling pathway and long non-coding RNAs in cancer

Wang, Jianbo; Shao, Ningsheng; Ding, Xiaowen; Tan, Bingxu; Song, Qingxu; Wang, Nana; Jia, Yibin; Ling, Hongbo; Cheng, Yufeng

doi:10.1016/j.canlet.2015.11.007

Cited by 60 publications

(57 citation statements)

References 50 publications

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“…Analyses using next-generation sequencers, such as chromatin immunoprecipitation (ChIP) followed by sequencing (ChIP-seq) demonstrate genome-wide DNA-binding landscapes of Smad proteins in various types of cells under different conditions [31]. TGF-β also regulates the expression of noncoding RNAs, such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) [32,33], and regulates various cell responses, including EMT.…”

Section: Regulation Of Gene Expressionmentioning

confidence: 99%

Intracellular and extracellular TGF-β signaling in cancer: some recent topics

et al. 2018

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Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively studied and well-characterized in many cancers, especially at early stages, accumulating evidence has revealed the critical roles of TGF-β as a pro-tumorigenic factor in various types of cancer. This review will focus on recent findings regarding epithelial-mesenchymal transition (EMT) induced by TGF-β, in relation to crosstalk with some other signaling pathways, and the roles of TGF-β in lung and pancreatic cancers, in which TGF-β has been shown to be involved in cancer progression. Recent findings also strongly suggested that targeting TGF-β signaling using specific inhibitors may be useful for the treatment of some cancers. TGF-β plays a pivotal role in the differentiation and function of regulatory T cells (Tregs). TGF-β is produced as latent high molecular weight complexes, and the latent TGF-β complex expressed on the surface of Tregs contains glycoprotein A repetitions predominant (GARP, also known as leucine-rich repeat containing 32 or LRRC32). Inhibition of the TGF-β activities through regulation of the latent TGF-β complex activation will be discussed.

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Section: Regulation Of Gene Expressionmentioning

confidence: 99%

Intracellular and extracellular TGF-β signaling in cancer: some recent topics

et al. 2018

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“…Studies investigating cross talk between the TGF-β signaling pathway and lncRNA in cells found that several members of the TGF-β pathway are targeted by lncRNA [27]. Wang et al [28] found that the upregulation of lncRNA-TSIX in systemic sclerosis fibroblasts might activate endogenous TGF-β signaling and play an important role in controlling collagen mRNA stabilization.…”

Section: Discussionmentioning

confidence: 99%

Expression Profiles of Long Noncoding RNA in UVA-Induced Human Skin Fibroblasts

Zheng

Peng

et al. 2017

Skin Pharmacol Physiol

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Background: Long noncoding RNA (lncRNA) are differentially expressed across stages of differentiation and development, but the role of lncRNA in human skin photoaging mechanisms remains poorly understood. Objective: This study aimed to determine lncRNA expression changes in human dermal fibroblasts (HDF) induced by repeated UVA irradiation and to explore correlations between lncRNA and skin photoaging prognosis. Methods: In the UVA-HDF group, HDF were subjected to repeated UVA irradiation (10 J/cm² UVA twice daily for 7 days); in the control group, HDF received no irradiation. High-throughput sequencing was used to detect lncRNA expression profiles. Functional annotation analysis and pathway enrichment were preformed via Gene Ontology and KEGG. Predicted lncRNA target genes were identified by bioinformatic analysis. Results: In the UVA-HDF group, 1,730 lncRNA exhibited over 2-fold expression changes compared with the control group: 1,494 were upregulated, and 236 downregulated. Predicted lncRNA targets were associated with matrix metalloproteinases, cathepsin D, mitogen-activated protein kinase and TGF-β signaling pathways, and collagen fiber metabolism following repeated UVA damaging mechanisms. Conclusions: lncRNA profiles were aberrantly expressed in UVA-HDF and might play a key role in skin photoaging. This study provides novel insights into the repeated UVA-damaging pathology and potential targets for treatment of human skin photoaging.

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“…It is widely accepted that TGF-βs act as both tumor suppressors and tumor promoters, depending on the cancer type and tumor development timing [39,40,41,42,43,44]. …”

Section: Tgf-β and Cancermentioning

confidence: 99%

TGF-β Signaling in Bone Remodeling and Osteosarcoma Progression

Lamora

Talbot

Mullard

et al. 2016

JCM

101

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Osteosarcomas are the most prevalent malignant primary bone tumors in children. Despite intensive efforts to improve both chemotherapeutics and surgical management, 40% of all osteosarcoma patients succumb to the disease. Specifically, the clinical outcome for metastatic osteosarcoma remains poor; less than 30% of patients who present metastases will survive five years after initial diagnosis. Treating metastatic osteosarcoma thus remains a challenge. One of the main characteristics of osteosarcomas is their ability to deregulate bone remodelling. The invasion of bone tissue by tumor cells indeed affects the balance between bone resorption and bone formation. This deregulation induces the release of cytokines or growth factors initially trapped in the bone matrix, such as transforming growth factor-β (TGF-β), which in turn promote tumor progression. Over the past years, there has been considerable interest in the TGF-β pathway within the cancer research community. This review discusses the involvement of the TGF-β signalling pathway in osteosarcoma development and in their metastatic progression.

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Crosstalk between transforming growth factor-β signaling pathway and long non-coding RNAs in cancer

Cited by 60 publications

References 50 publications

Intracellular and extracellular TGF-β signaling in cancer: some recent topics

Intracellular and extracellular TGF-β signaling in cancer: some recent topics

Expression Profiles of Long Noncoding RNA in UVA-Induced Human Skin Fibroblasts

TGF-β Signaling in Bone Remodeling and Osteosarcoma Progression

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