Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation

Békássy, Zivile; Fagerström, Ingrid Lopatko; Bäder, Michael; Karpman, Diana

doi:10.1038/s41577-021-00634-8

Cited by 89 publications

(75 citation statements)

References 277 publications

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Section: Introductionmentioning

confidence: 99%

“…It has been recently proposed that the kinin system, RAS and complement system are closely interconnected and have a major role in regulating vascular tone and inflammation ( 135 ). Ang-(1–7), by AT 2 R-mediated signaling, can counter-regulate blood pressure elevation by stimulating bradykinin production ( 136 ) and boosting the bradykinin–NO–cGMP pathway ( 135 ). In pathological conditions, particularly SAH ( 137 ), over-activation of the complement system induces leukocyte recruitment and extravasation increasing vascular permeability that can lead to tissue edema ( 135 ).…”

Section: Introductionmentioning

confidence: 99%

“…Ang-(1–7), by AT 2 R-mediated signaling, can counter-regulate blood pressure elevation by stimulating bradykinin production ( 136 ) and boosting the bradykinin–NO–cGMP pathway ( 135 ). In pathological conditions, particularly SAH ( 137 ), over-activation of the complement system induces leukocyte recruitment and extravasation increasing vascular permeability that can lead to tissue edema ( 135 ). Thus, Ang-(1–7) given after SAH could restore the balance in vascular permeability ( 37 ), mitigating pro-inflammatory mechanisms in brain tissue and blood vessels.…”

Section: Introductionmentioning

confidence: 99%

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Angiotensin-(1–7) as a Potential Therapeutic Strategy for Delayed Cerebral Ischemia in Subarachnoid Hemorrhage

et al. 2022

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Aneurysmal subarachnoid hemorrhage (SAH) is a substantial cause of mortality and morbidity worldwide. Moreover, survivors after the initial bleeding are often subject to secondary brain injuries and delayed cerebral ischemia, further increasing the risk of a poor outcome. In recent years, the renin–angiotensin system (RAS) has been proposed as a target pathway for therapeutic interventions after brain injury. The RAS is a complex system of biochemical reactions critical for several systemic functions, namely, inflammation, vascular tone, endothelial activation, water balance, fibrosis, and apoptosis. The RAS system is classically divided into a pro-inflammatory axis, mediated by angiotensin (Ang)-II and its specific receptor AT1R, and a counterbalancing system, presented in humans as Ang-(1–7) and its receptor, MasR. Experimental data suggest that upregulation of the Ang-(1–7)/MasR axis might be neuroprotective in numerous pathological conditions, namely, ischemic stroke, cognitive disorders, Parkinson’s disease, and depression. In the presence of SAH, Ang-(1–7)/MasR neuroprotective and modulating properties could help reduce brain damage by acting on neuroinflammation, and through direct vascular and anti-thrombotic effects. Here we review the role of RAS in brain ischemia, with specific focus on SAH and the therapeutic potential of Ang-(1–7).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Angiotensin-(1–7) as a Potential Therapeutic Strategy for Delayed Cerebral Ischemia in Subarachnoid Hemorrhage

et al. 2022

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“…Many intuitions were favorable. Some suggested new treatment approaches, later summarized in commentaries or reviews in high-rank journals [ 5 ].…”

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confidence: 99%

“…Many intuitions were favorable. Some suggested new treatment approaches, later summarized in commentaries or reviews in high-rank journals[5].The availability of vaccines, their unforeseen side effects, and their indications are now being increasingly reported, while the current wave of the epidemics is likely to lead to submissions of reports on vaccine escape and consideration of future needs.Papers on side effects and on the miracles being achieved using the new drugs will hopefully soon follow.While, as editors, we are obliged to select from among the many reports submitted, as physicians and human beings we applaud all our colleagues who have sought to analyze and discuss their experiences, managing to write and engage in discussion at a moment when we often have very little time.…”

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confidence: 99%

What have we learnt from the COVID-19 epidemic? Considerations of a troubled editor after two troubled years

Piccoli

2022

J Nephrol

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The term "lessons learnt" is increasingly appearing in medical journals in conjunction with COVID-19, coronavirus epidemic, or SARS-CoV-19: to date, 1727 articles on such lessons have been published (as a title or abstract) on Pub-Med. Although, in comparison with the approximately 8000 entries per year on dialysis, 7000 on colon cancer or 550 on IgA nephropathy, this number may appear insignificant, it does make it seem that learning has taken place.Most of us would indeed like to learn from this experience, capitalizing on the terrible challenges we initially faced and the difficulties we continue to have to overcome every day, not to mention those minor annoyances that we have become used to-cleaning foggy eyeglasses or finding that hydro-alcoholic solution scrubs are causing the skin on our hands to crack.The papers, submitted in waves, and describing what was happening around us, reflected what was happening during the past two troubled years. The first paper we published back in March 2020 was a heroic attempt by the Italian Society of Nephrology to summarize directions, and give practical indications on how to deal with the unexpected, overwhelming disaster. Looking at it now, it may seem almost naive, but its insistence on protecting patients, protecting the team and protecting the dialysis ward was innovative, considering that it was submitted before the World Health Organization had declared the existence of the pandemic, and in a context in which surgical masks were considered useless, and potentially dangerous as they might "scare" patients [1, 2]. While many indications are no longer shared, and several have been added, this was one of the first position papers by a nephrology society in Europe.The lockdown period was characterized by the submis-* Giorgina Barbara Piccoli

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Incorporating Anticoagulant and Antiplatelet Dual Functional Groups into Thermosetting Polymer Chain for Enhancing Antithrombogenicity

Wang,

Liu,

Zhang

et al. 2023

Adv Healthcare Materials

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In clinical practice, high‐effective antithrombosis remains a challenge for blood‐contacting medical devices. Inspired by the enhanced antithrombogenicity of anticoagulant and antiplatelet combination therapy, a strategy is proposed to synthesize dual‐pathway antithrombotic polymers by incorporating anticoagulant and antiplatelet dual functional groups into a single thermosetting polymer chain. The synthesized polymer shows increased antithrombogenicity in vitro, with prolonged activated partial thromboplastin time (APTT) and decreased platelet adhesion. Additionally, it downregulates the expression of coagulation‐ and inflammation‐related factors in rabbit plasma after ex vivo arteriovenous shunt assay and maintains patency of small vascular grafts for at least 6 months without thrombosis on the luminal surface after in vivo replacement of rabbit carotid artery. This work provides a new approach to producing novel antithrombotic polymers for blood‐contacting medical devices.

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Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation

Cited by 89 publications

References 277 publications

Angiotensin-(1–7) as a Potential Therapeutic Strategy for Delayed Cerebral Ischemia in Subarachnoid Hemorrhage

Angiotensin-(1–7) as a Potential Therapeutic Strategy for Delayed Cerebral Ischemia in Subarachnoid Hemorrhage

What have we learnt from the COVID-19 epidemic? Considerations of a troubled editor after two troubled years

Incorporating Anticoagulant and Antiplatelet Dual Functional Groups into Thermosetting Polymer Chain for Enhancing Antithrombogenicity

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