Crosstalk between the peripheral nervous system and breast cancer influences tumor progression

Hu, Jianming; Chen, Wuzhen; Shen, Lianfang; Chen, Zhigang; Huang, Jian

doi:10.1016/j.bbcan.2022.188828

Cited by 14 publications

(9 citation statements)

References 209 publications

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“…Single cell-based spatial mapping with imaging mass cytometry was used to identify the colocalization of neural and vascular structures, indicating the presence of neurovascular niches within tumor tissue. Cancer cells can release various signaling molecules, including growth factors and cytokines, that play a role in recruiting both sprouting axons (microaxons) and endothelial cells (microvessels) to the TME ( 343 ). This phenomenon is referred to as neurotropism, and it has been observed in several types of cancers, including breast cancer ( 343 , 344 ).…”

Section: Breast Tmementioning

confidence: 99%

“…Cancer cells can release various signaling molecules, including growth factors and cytokines, that play a role in recruiting both sprouting axons (microaxons) and endothelial cells (microvessels) to the TME ( 343 ). This phenomenon is referred to as neurotropism, and it has been observed in several types of cancers, including breast cancer ( 343 , 344 ). The exact mechanisms by which cancer cells influence axon recruitment are still an area of active research.…”

Section: Breast Tmementioning

confidence: 99%

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Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics

Akinsipe,

Mohamedelhassan,

Akinpelu

et al. 2024

Front. Immunol.

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The breast cancer tumor microenvironment (TME) is dynamic, with various immune and non-immune cells interacting to regulate tumor progression and anti-tumor immunity. It is now evident that the cells within the TME significantly contribute to breast cancer progression and resistance to various conventional and newly developed anti-tumor therapies. Both immune and non-immune cells in the TME play critical roles in tumor onset, uncontrolled proliferation, metastasis, immune evasion, and resistance to anti-tumor therapies. Consequently, molecular and cellular components of breast TME have emerged as promising therapeutic targets for developing novel treatments. The breast TME primarily comprises cancer cells, stromal cells, vasculature, and infiltrating immune cells. Currently, numerous clinical trials targeting specific TME components of breast cancer are underway. However, the complexity of the TME and its impact on the evasion of anti-tumor immunity necessitate further research to develop novel and improved breast cancer therapies. The multifaceted nature of breast TME cells arises from their phenotypic and functional plasticity, which endows them with both pro and anti-tumor roles during tumor progression. In this review, we discuss current understanding and recent advances in the pro and anti-tumoral functions of TME cells and their implications for developing safe and effective therapies to control breast cancer progress.

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Section: Breast Tmementioning

confidence: 99%

Section: Breast Tmementioning

confidence: 99%

Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics

Akinsipe,

Mohamedelhassan,

Akinpelu

et al. 2024

Front. Immunol.

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“…Breast cancer cells (BCCs) secrete neuroactive chemicals, such as neurotrophic and axon guidance molecules, to encourage the expansion and branching of nearby peripheral nerves. While the parasympathetic nerve and sensory nerve mostly have anti-tumor actions in the advancement of breast cancer, the sympathetic nerve promotes the growth of breast cancer [ 56 ]. Peripheral nerves might, thus, influence the growth of breast cancer by indirectly acting on immune cells, in addition to directly binding to the appropriate BCC receptors via the release of neurotransmitters.…”

Section: Effect Of Biological Neural Signals On Stem Cell Differentia...mentioning

confidence: 99%

Magnetic Nanomaterials Mediate Electromagnetic Stimulations of Nerves for Applications in Stem Cell and Cancer Treatments

Wang

Duan

et al. 2023

JFB

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Although some progress has been made in the treatment of cancer, challenges remain. In recent years, advancements in nanotechnology and stem cell therapy have provided new approaches for use in regenerative medicine and cancer treatment. Among them, magnetic nanomaterials have attracted widespread attention in the field of regenerative medicine and cancer; this is because they have high levels of safety and low levels of invasibility, promote stem cell differentiation, and affect biological nerve signals. In contrast to pure magnetic stimulation, magnetic nanomaterials can act as amplifiers of an applied electromagnetic field in vivo, and by generating different effects (thermal, electrical, magnetic, mechanical, etc.), the corresponding ion channels are activated, thus enabling the modulation of neuronal activity with higher levels of precision and local modulation. In this review, first, we focused on the relationship between biological nerve signals and stem cell differentiation, and tumor development. In addition, the effects of magnetic nanomaterials on biological neural signals and the tumor environment were discussed. Finally, we introduced the application of magnetic-nanomaterial-mediated electromagnetic stimulation in regenerative medicine and its potential in the field of cancer therapy.

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“…Cancer cells have been observed to produce neurotropic and axon guidance molecules, which promote the growth of intratumoral axons [ 12 , 13 , 15 , 19 , 20 ]. Their functions in cancer biology depend on multiple factors, including the type of cancer, the nature of the involved neurons, and the mechanisms leading to their aberrant expression in cancer cells will require further investigation [ 21 , 22 , 23 ]. Seminal studies have implicated the role of Semaphorins in cancer-induced neurogenesis and aggressivity [ 12 , 15 , 24 ], and in our previous study, we identified the TGFβ pathway as a mediator of cancer innervation, promoting the expression of the Semaphorin-4F in breast cancer cells and leading to increased cancer innervation associated with enhanced metastasis [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

A CRISPR/Cas9-Based Assay for High-Throughput Studies of Cancer-Induced Innervation

Galappaththi

Katz

Howze

et al. 2023

Cancers

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The aggressive nature of certain cancers and their adverse effects on patient outcomes have been linked to cancer innervation, where neurons infiltrate and differentiate within the cancer stroma. Recently we demonstrated how cancer plasticity and TGFβ signaling could promote breast cancer innervation that is associated with increased cancer aggressivity. Despite the promising potential of cancer innervation as a target for anti-cancer therapies, there is currently a significant lack of effective methods to study cancer-induced neuronal differentiation, hindering the development of high-throughput approaches for identifying new targets or pharmacological inhibitors against cancer innervation. To overcome this challenge, we used CRISPR-based endogenous labeling of the neuronal marker β3-tubulin in neuronal precursors to investigate cancer-induced neuronal differentiation in nerve-cancer cocultures and provide a tool that allows for better standardization and reproducibility of studies about cancer-induced innervation. Our approach demonstrated that β3-tubulin gene editing did not affect neuronal behavior and enabled accurate reporting of cancer-induced neuronal differentiation dynamics in high-throughput settings, which makes this approach suitable for screening large cohorts of cells or testing various biological contexts. In a more context-based approach, by combining this method with a cell model of breast cancer epithelial-mesenchymal transition, we revealed the role of cancer cell plasticity in promoting neuronal differentiation, suggesting that cancer innervation represents an underexplored path for epithelial-mesenchymal transition-mediated cancer aggressivity.

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Crosstalk between the peripheral nervous system and breast cancer influences tumor progression

Cited by 14 publications

References 209 publications

Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics

Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics

Magnetic Nanomaterials Mediate Electromagnetic Stimulations of Nerves for Applications in Stem Cell and Cancer Treatments

A CRISPR/Cas9-Based Assay for High-Throughput Studies of Cancer-Induced Innervation

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