Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation

Gureev, Artem P.; Popov, Vasily N.; Starkov, Anatoly A.

doi:10.1016/j.expneurol.2020.113285

Cited by 55 publications

(38 citation statements)

References 130 publications

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“…An essential gene is the BDNF gene and the rs6265 polymorphism among the analyzed genes. The product of this gene is significant for working memory and long-term potentiation [33]. The results obtained confirm the assumption that working memory is crucial for developing success in the VOI.…”

Section: Discussionsupporting

confidence: 77%

The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface

Turovsky¹,

Gureev²,

Vitkalova³

et al. 2021

Journal of Integrative Neuroscience

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A video-oculographic interface is a system for controlling objects using eye movements. The video-oculographic interface differs from other brain-computer interfaces regarding its improved accuracy, simplicity, and ergonomics. Despite these advantages, all users are not equally successful in mastering these various devices. It has been suggested that the genetic characteristics of the operators may determine the efficiency of video-oculographic interface mastery. We recruited healthy users with rs6313, rs2030324, rs429358, rs10119, rs457062, rs4290270, and rs6265 polymorphisms and analyzed the relationships between these polymorphisms and values of success in video-oculographic interface mastery. We found that carriers of the G/G genotype of the rs6265 polymorphism (BDNF gene) demonstrated the best results in video-oculographic interface mastery. In contrast, carriers of the A/A genotype were characterized by large standard deviations in the average amplitude of eye movement and the range of eye movement negatively correlated with goal achievement. This can be explained through the fact that carriers of the A/A genotype demonstrate lower synaptic plasticity due to reduced expression of BDNF when compared to carriers of the G/G genotype. These results expand our understanding of the genetic predictors of successful video-oculographic interface management, which will help to optimize device management training for equipment operators and people with disabilities.

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Section: Discussionsupporting

confidence: 77%

The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface

Turovsky¹,

Gureev²,

Vitkalova³

et al. 2021

Journal of Integrative Neuroscience

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“…In fact, it has been demonstrated that restoring mTOR signaling with rapamycin ameliorates Aβ and tau pathology in several mouse models, preserves blood brain barrier (BBB) integrity, restores cerebral blood flow and brain vascular density and rescues cognitive deficits (Lin et al, 2013;Van Skike et al, 2018;Gureev et al, 2020).…”

Section: Rapamycinmentioning

confidence: 99%

Repositioning of Immunomodulators: A Ray of Hope for Alzheimer’s Disease?

et al. 2020

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Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder characterized by cognitive decline and by the presence of amyloid β plaques and neurofibrillary tangles in the brain. Despite recent advances in understanding its pathophysiological mechanisms, to date, there are no disease-modifying therapeutic options, to slow or halt the evolution of neurodegenerative processes in AD. Current pharmacological treatments only transiently mitigate the severity of symptoms, with modest or null overall improvement. Emerging evidence supports the concept that AD is affected by the impaired ability of the immune system to restrain the brain’s pathology. Deep understanding of the relationship between the nervous and the immune system may provide a novel arena to develop effective and safe drugs for AD treatment. Considering the crucial role of inflammatory/immune pathways in AD, here we discuss the current status of the immuno-oncological, immunomodulatory and anti-TNF-α drugs which are being used in preclinical studies or in ongoing clinical trials by means of the drug-repositioning approach.

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“…As a consequence, Ca 2+ and calmodulin-dependent protein kinase II (CaMKII) and protein kinase C (PKC) are activated. These, in turn, inhibit basic signaling pathways mediated by the Nrf/ARE transcription factor providing protection against oxidative stress [ 114 ].…”

Section: Figurementioning

confidence: 99%

The Relationship between the Level of Anterior Cingulate Cortex Metabolites, Brain-Periphery Redox Imbalance, and the Clinical State of Patients with Schizophrenia and Personality Disorders

et al. 2020

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Schizophrenia is a complex mental disorder whose course varies with periods of deterioration and symptomatic improvement without diagnosis and treatment specific for the disease. So far, it has not been possible to clearly define what kinds of functional and structural changes are responsible for the onset or recurrence of acute psychotic decompensation in the course of schizophrenia, and to what extent personality disorders may precede the appearance of the appropriate symptoms. The work combines magnetic resonance spectroscopy imaging with clinical evaluation and laboratory tests to determine the likely pathway of schizophrenia development by identifying peripheral cerebral biomarkers compared to personality disorders. The relationship between the level of metabolites in the brain, the clinical status of patients according to International Statistical Classification of Diseases and Related Health Problems, 10th Revision ICD-10, duration of untreated psychosis (DUP), and biochemical indices related to redox balance (malondialdehyde), the efficiency of antioxidant systems (FRAP), and bioenergetic metabolism of mitochondria, were investigated. There was a reduction in the level of brain N-acetyl-aspartate and glutamate in the anterior cingulate gyrus of patients with schisophrenia compared to the other groups that seems more to reflect a biological etiopathological factor of psychosis. Decreased activity of brain metabolites correlated with increased peripheral oxidative stress (increased malondialdehyde MDA) associated with decreased efficiency of antioxidant systems (FRAP) and the breakdown of clinical symptoms in patients with schizophrenia in the course of psychotic decompensation compared to other groups. The period of untreated psychosis correlated negatively with glucose value in the brain of people with schizophrenia, and positively with choline level. The demonstrated differences between two psychiatric units, such as schizophrenia and personality disorders in relation to healthy people, may be used to improve the diagnosis and prognosis of schizophrenia compared to other heterogenous psychopathology in the future. The collapse of clinical symptoms of patients with schizophrenia in the course of psychotic decompensation may be associated with the occurrence of specific schizotypes, the determination of which is possible by determining common relationships between changes in metabolic activity of particular brain structures and peripheral parameters, which may be an important biological etiopathological factor of psychosis. Markers of peripheral redox imbalance associated with disturbed bioenergy metabolism in the brain may provide specific biological factors of psychosis however, they need to be confirmed in further studies.

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Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation

Cited by 55 publications

References 130 publications

The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface

The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface

Repositioning of Immunomodulators: A Ray of Hope for Alzheimer’s Disease?

The Relationship between the Level of Anterior Cingulate Cortex Metabolites, Brain-Periphery Redox Imbalance, and the Clinical State of Patients with Schizophrenia and Personality Disorders

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