Crosstalk between the aging intestinal microflora and the brain in ischemic stroke

Pluta, Ryszard; Jabłoński, Mirosław; Januszewski, Sławomir; Czuczwar, Stanisław J.

doi:10.3389/fnagi.2022.998049

Cited by 3 publications

(1 citation statement)

References 195 publications

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“…Moreover, the effects of ischemic changes may have a long-term impact on central structures involving inflammatory factors and be associated with the formation of amyloid plaques and Alzheimer's-type dementia [31,32]. More information indicates that disorders in the microbiota-gut-brain axis, manifesting with age and the onset of ischemic stroke, may be associated with the development of risk factors for stroke [33]. Approximately 3% of patients with stroke develop epilepsy [34].…”

Section: Introductionmentioning

confidence: 99%

Selected Biomarkers of Oxidative Stress and Energy Metabolism Disorders in Neurological Diseases

et al. 2023

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Neurological diseases can be broadly divided according to causal factors into circulatory system disorders leading to ischemic stroke; degeneration of the nerve cells leading to neurodegenerative diseases, such as Alzheimer’s (AD) and Parkinson’s (PD) diseases, and immune system disorders; bioelectric activity (epileptic) problems; and genetically determined conditions as well as viral and bacterial infections developing inflammation. Regardless of the cause of neurological diseases, they are usually accompanied by disturbances of the central energy in a completely unexplained mechanism. The brain makes up only 2% of the human body’s weight; however, while working, it uses as much as 20% of the energy obtained by the body. The energy requirements of the brain are very high, and regulatory mechanisms in the brain operate to ensure adequate neuronal activity. Therefore, an understanding of neuroenergetics is rapidly evolving from a “neurocentric” view to a more integrated picture involving cooperativity between structural and molecular factors in the central nervous system. This article reviewed selected molecular biomarkers of oxidative stress and energy metabolism disorders such as homocysteine, DNA damage such as 8-oxo2dG, genetic variants, and antioxidants such as glutathione in selected neurological diseases including ischemic stroke, AD, PD, and epilepsy. This review summarizes our and others’ recent research on oxidative stress in neurological disorders. In the future, the diagnosis and treatment of neurological diseases may be substantially improved by identifying specific early markers of metabolic and energy disorders.

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Section: Introductionmentioning

confidence: 99%

Selected Biomarkers of Oxidative Stress and Energy Metabolism Disorders in Neurological Diseases

et al. 2023

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Along the microbiota–gut–brain axis: Use of plant polysaccharides to improve mental disorders

Gao,

Liang,

Liu

2024

International Journal of Biological Macromolecules

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Gut Microbiota. Neuropolen for Recovery after A Ischemic Stroke

GIURGIU,

COJOCARU

2023

AnnalsARSciBio

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Background The brain possesses an extraordinary ability to heal itself after a stroke. This ability is known as neuroplasticity. The relationship between the gut microbiota and stroke is recent, with early studies dating from 2013. Recent studies support that gut microbiota is associated with ischemic stroke through the gut-brain axis, thereby modulating stroke pathogenesis. Objectives Gut dysbiosis, defined as alterations to the gut microbial communities has been proposed in stroke. To determine whether Neuropolen can be a potential treatment for recovery after a stroke. Material and methods The 2-way communication between the gut and the brain, which involves the brain, the gut microbiota, and the intestinal tissue, has been suggested as a key component of stroke outcome. To arrive at these observations, authors examined how Neuropolen and diet solve disabilities. Results The gut microbiota can increase the risk of a cerebrovascular event, playing a role in the onset of stroke. Conversely, stroke can induce dysbiosis of the gut microbiota. We found that Neuropolen may be important for functional recovery after a stroke. Neuropolen that may help minimize the degree of complications, stimulation enhances plasticity of the brain, in which noninjured parts of the brain can pick up the job of the injured brain areas. Conclusion In this presentation, authors describe the role of the gut microbiota, microbiome and microbiota-derived metabolites in stroke, and their use as therapeutic targets. Neuropolen may be a potential therapy for recovery after a stroke, it can quickly feed oxygen to the brain and protect brain cells.

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Crosstalk between the aging intestinal microflora and the brain in ischemic stroke

Cited by 3 publications

References 195 publications

Selected Biomarkers of Oxidative Stress and Energy Metabolism Disorders in Neurological Diseases

Selected Biomarkers of Oxidative Stress and Energy Metabolism Disorders in Neurological Diseases

Along the microbiota–gut–brain axis: Use of plant polysaccharides to improve mental disorders

Gut Microbiota. Neuropolen for Recovery after A Ischemic Stroke

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