Crosstalk between MiRNAs/lncRNAs and PI3K/AKT signaling pathway in diabetes mellitus: Mechanistic and therapeutic perspectives

Aghaei-Zarch, Seyed Mohsen

doi:10.1016/j.ncrna.2024.01.005

Cited by 7 publications

(2 citation statements)

References 107 publications

(110 reference statements)

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“…The ceRNA mechanism is an essential method through which lncRNAs can control the expression of other mRNAs and carry out their biological functions. This hypothesis suggests that if both lncRNAs and mRNAs share the same miRNA binding sites, known as miRNA response elements (MREs), they will compete to bind miRNAs and regulate expression [ 73 , 74 ]. As shown in Fig.…”

Section: Role Of Loxl1-as1 In Various Cancersmentioning

confidence: 99%

Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors

Fu,

Ji,

Tang

et al. 2024

Clin Exp Med

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Long non-coding RNAs (lncRNAs) are transcripts that contain more than 200 nucleotides. Despite their inability to code proteins, multiple studies have identified their important role in human cancer through different mechanisms. LncRNA lysyl oxidase like 1 antisense RNA 1 (LOXL1-AS1), a newly discovered lncRNA located on human chromosome 15q24.1, has recently been shown to be involved in the occurrence and progression of various malignancies, such as colorectal cancer, gastric cancer, hepatocellular carcinoma, prostate cancer, non-small cell lung cancer, ovarian cancer, cervical cancer, breast cancer, glioma, thymic carcinoma, pancreatic carcinoma. LOXL1-AS1 acts as competitive endogenous RNA (ceRNA) and via sponging various miRNAs, including miR-374b-5p, miR-21, miR-423-5p, miR-589-5p, miR-28-5p, miR-324-3p, miR-708-5p, miR-143-3p, miR-18b-5p, miR-761, miR-525-5p, miR-541-3p, miR-let-7a-5p, miR-3128, miR-3614-5p, miR-377-3p and miR-1224-5p to promote tumor cell proliferation, invasion, migration, apoptosis, cell cycle, and epithelial–mesenchymal transformation (EMT). In addition, LOXL1-AS1 is involved in the regulation of P13K/AKT and MAPK signaling pathways. This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.

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Section: Role Of Loxl1-as1 In Various Cancersmentioning

confidence: 99%

Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors

Fu,

Ji,

Tang

et al. 2024

Clin Exp Med

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“…Other miRNAs could be prognostic markers for CC including miR-188, miR-99a, miR-223, and miR-125b (Gao et al 2018 ), miR-145, and miR-196 (Chen et al 2017 ). By utilizing current databases and datasets, cutting-edge biomarker selection techniques, and modern bioinformatic tools to investigate CC samples at different stages, it is possible to create a comprehensive collection of non-coding RNA panels (Bolha et al 2017 ), of which miRNAs and lncRNAs could be very useful cancer biomarkers (Fardi et al 2023 ; Huang et al 2023 ; Aghaei-Zarch 2024 ; Huang and Aghaei-Zarch 2024 ; Shirvani et al 2022 ). This study suggested an approach that aims to thoroughly extract and analyze RNA-based biomarkers as a means of gaining deeper insight into the disrupted pathways and RNA molecules associated with cervical cancer.…”

Section: Let-7 and Gynecological Cancermentioning

confidence: 99%

The microRNA Let-7 and its exosomal form: Epigenetic regulators of gynecological cancers

Wang,

Zhou,

Zhu

et al. 2024

Cell Biol Toxicol

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Many types of gynecological cancer (GC) are often silent until they reach an advanced stage, and are therefore often diagnosed too late for effective treatment. Hence, there is a real need for more efficient diagnosis and treatment for patients with GC. During recent years, researchers have increasingly studied the impact of microRNAs cancer development, leading to a number of applications in detection and treatment. MicroRNAs are a particular group of tiny RNA molecules that regulate regular gene expression by affecting the translation process. The downregulation of numerous miRNAs has been observed in human malignancies. Let-7 is an example of a miRNA that controls cellular processes as well as signaling cascades to affect post-transcriptional gene expression. Recent research supports the hypothesis that enhancing let-7 expression in those cancers where it is downregulated may be a potential treatment option. Exosomes are tiny vesicles that move through body fluids and can include components like miRNAs (including let-7) that are important for communication between cells. Studies proved that exosomes are able to enhance tumor growth, angiogenesis, chemoresistance, metastasis, and immune evasion, thus suggesting their importance in GC management. Graphical Abstract Impact of let-7 on female malignancies and diseases of the female reproductive tract. Let-7 expression is dysregulated in a variety of gynaecological and obstetric disorders.

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The scaffold protein disabled 2 (DAB2) and its role in tumor development and progression

Pandya,

Parikh,

Gena

et al. 2024

Mol Biol Rep

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Crosstalk between MiRNAs/lncRNAs and PI3K/AKT signaling pathway in diabetes mellitus: Mechanistic and therapeutic perspectives

Cited by 7 publications

References 107 publications

Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors

Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors

The microRNA Let-7 and its exosomal form: Epigenetic regulators of gynecological cancers

The scaffold protein disabled 2 (DAB2) and its role in tumor development and progression

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