Crosstalk between metabolism and cell death in tumorigenesis

Abstract

It is generally recognized that tumor cells proliferate more rapidly than normal cells. Due to such an abnormally rapid proliferation rate, cancer cells constantly encounter the limits of insufficient oxygen and nutrient supplies. To satisfy their growth needs and resist adverse environmental events, tumor cells modify the metabolic pathways to produce both extra energies and substances required for rapid growth. Realizing the metabolic characters special for tumor cells will be helpful for eliminating them during therapy. Cell death is a hot topic of long-term study and targeting cell death is one of the most effective ways to repress tumor growth. Many studies have successfully demonstrated that metabolism is inextricably linked to cell death of cancer cells. Here we summarize the recently identified metabolic characters that specifically impact on different types of cell deaths and discuss their roles in tumorigenesis.

Causality of genetically determined metabolites on susceptibility to prevalent urological cancers: a two-sample Mendelian randomization study and meta-analysis

“…Altered levels of bile acid conjugates, such as glycoursodeoxycholic acid sulfate and taurochenodeoxycholate, may disrupt homeostatic processes ( Chiang, 2013 ). These disrupted homeostatic processes, in turn, regulate metabolism and cell death pathways, thereby influencing the tumor microenvironment and playing a crucial role in tumorigenesis and tumor progression ( Yang et al, 2024 ). Simultaneously, metabolites like 3-ethylcatechol sulfate, related to catechol metabolism, could influence oxidative stress and hormonal imbalances ( Chainy and Sahoo, 2020 ).…”

Importance of Energy, Dietary Protein Sources and Amino Acids Composition in the Regulation of Metabolism: An Indissoluble Dynamic Combination for Life

“…The tumor microenvironment is also implicated in the metabolic regulation of cell death, suggesting that modulating cancer cell metabolism could be a viable and effective strategy to regulate tumorigenesis [94]. The characterization of metabolic reprogramming in the tumor microenvironment is becoming increasingly crucial in cancer research and patient care [95].…”

Table3.DOCX

“…Altered levels of bile acid conjugates, such as glycoursodeoxycholic acid sulfate and taurochenodeoxycholate, may disrupt homeostatic processes (Chiang, 2013). These disrupted homeostatic processes, in turn, regulate metabolism and cell death pathways, thereby influencing the tumor microenvironment and playing a crucial role in tumorigenesis and tumor progression (Yang et al, 2024). Simultaneously, metabolites like 3-ethylcatechol sulfate, related to Frontiers in Genetics frontiersin.org catechol metabolism, could influence oxidative stress and hormonal imbalances (Chainy and Sahoo, 2020).…”