Crosstalk between keratinocytes and immune cells in inflammatory skin diseases

Ni, Xinhui; Lai, Yuping

doi:10.37349/ei.2021.00028

Cited by 9 publications

(6 citation statements)

References 116 publications

(129 reference statements)

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“…A growing number of recent studies have demonstrated that keratinocytes in psoriasis interact with immune cells to form a feed-forward inflammatory loop. They act as a trigger and amplifier of the inflammatory response by recruiting and activating immune cells, thereby triggering local inflammation, which plays important roles in the initiation, maintenance, and relapse phases of psoriasis ( 64 ).…”

Section: Contribution Of Mast Cells To the Immunopathogenesis Of Psor...mentioning

confidence: 99%

Mast cells as important regulators in the development of psoriasis

Zhou

Chen²,

Zhang³

2022

Front. Immunol.

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Psoriasis is a chronic inflammatory immune skin disease mediated by genetic and environmental factors. As a bridge between innate and adaptive immunity, mast cells are involved in the initiation, development, and maintenance of psoriasis by interactions and communication with a variety of cells. The current review describes interactions of mast cells with T cells, Tregs, keratinocytes, adipocytes, and sensory neurons in psoriasis to emphasize the important role of mast cell-centered cell networks in psoriasis.

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Section: Contribution Of Mast Cells To the Immunopathogenesis Of Psor...mentioning

confidence: 99%

Mast cells as important regulators in the development of psoriasis

Zhou

Chen²,

Zhang³

2022

Front. Immunol.

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“…In AD lesions, cytokines released by inflammatory cells exacerbate inflammation [ 14 , 34 ]. Hence, we measured the gene expression levels of IL-4, IL-5, and IL-13 as Th2 cytokines, IFN-γ and IL-12 A as Th1 cytokines, and IL-1β as a pro-inflammatory cytokine in ear tissue of AD-induced mice using RT- q PCR.…”

Section: Resultsmentioning

confidence: 99%

“…When AD progresses to the chronic phase, Th1 response is also increased with the secretion of interferon (IFN)-γ [ 13 ]. Immune cells recruited into skin lesions secrete inflammatory mediators that activate keratinocytes and exacerbate inflammatory responses [ 14 ]. Accordingly, regulating the inflammatory responses of keratinocytes and immune cells is the main therapeutic approach for AD.…”

Section: Introductionmentioning

confidence: 99%

Lupeol alleviates atopic dermatitis-like skin inflammation in 2,4-dinitrochlorobenzene/Dermatophagoides farinae extract-induced mice

Bae

Jeong

Choi

et al. 2023

BMC Pharmacol Toxicol

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Background Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects from children to adults widely, presenting symptoms such as pruritus, erythema, scaling, and dryness. Lupeol, a pentacyclic triterpenoid, has anti-inflammatory and antimicrobial activities. Based on these properties, the therapeutic effects of lupeol on skin disorders have been actively studied. In the present study, we aimed to determine the effectiveness of lupeol on AD. Methods We utilized tumor necrosis factor (TNF)-α/interferon (IFN)-γ-stimulated keratinocytes and 2, 4-dinitrochlorobenzene/Dermatophagoides farinae extract (DFE)-induced AD mice to confirm the action. Results Lupeol inhibited TNF-α/IFN-γ-stimulated keratinocytes activation by reducing the expressions of pro-inflammatory cytokines and chemokines which are mediated by the activation of signaling molecules such as signal transducer and activator of transcription 1, mitogen-activated protein kinases (p38 and ERK), and nuclear factor-κB. Oral administration of lupeol suppressed epidermal and dermal thickening and immune cell infiltration in ear tissue. Immunoglobulin (Ig) E (total and DFE-specific) and IgG2a levels in serum were also reduced by lupeol. The gene expression and protein secretion of T helper (Th) 2 cytokines, Th1 cytokines, and pro-inflammatory cytokine in ear tissue were decreased by lupeol. Conclusions These results suggest that lupeol has inhibitory effects on AD-related responses. Therefore, lupeol could be a promising therapeutic agent for AD.

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“…Specific stimuli induce keratinocytes to produce a range of inflammatory molecules for the homing of immune cells in AD skin lesions. TARC and MDC are expressed strongly by keratinocytes and are involved in the recruitment of 2 lymphocytes [55]. In patients with AD, the levels of TARC and MDC, as well as their receptor C-C chemokine receptor type 4 (CCR4), are higher than those in normal individuals.…”

Section: Discussionmentioning

confidence: 99%

Effect of Sopoongsan on Skin Inflammation and Hyperlocomotion in Socially Isolated Mice with Atopic Dermatitis

Nguyen

Choi

Shin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Psychological stress is a major exacerbating factor of atopic dermatitis (AD), a chronic in ammatory skin disease. Sopoongsan (SPS), a traditional herbal formula, has been indicated for the treatment of various skin disorders, including AD. is study investigated the e ects of SPS on a 2,4-dinitrochlorobenzene-(DNCB-) induced AD mice model exposed to social isolation (SI) stress. e severity of the AD symptoms and behavioral abnormalities was evaluated. SPS reduced the clinical skin score as evaluated with the SCORing Atopic Dermatitis (SCORAD) index and suppressed the cutaneous in ltration of T-lymphocyte cells, mast cells, and eosinophils in SI-AD mice. e SPS treatment decreased the total distance and mean speed and increased resting time in the open eld test (OFT) for these mice. In addition, the time spent in the social zone in the social interaction test also improved when SPS treatment was given. e levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in the prefrontal cortex (PFC) in the SI-AD mice were reduced by the oral administration of SPS. HaCaT and BV2 cells were used for the in vitro experiments. e pretreatment with SPS reduced the protein levels of the thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in the HaCaT cells stimulated with TNF-α and interferon-gamma (IFN-c) (TI). SPS also suppressed TNF-α and IL-6 secretion in lipopolysaccharide-(LPS-) stimulated BV2 cells. ese results imply that SPS could be a promising candidate for the treatment of AD in patients under stress conditions and at risk of exacerbation.

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Crosstalk between keratinocytes and immune cells in inflammatory skin diseases

Cited by 9 publications

References 116 publications

Mast cells as important regulators in the development of psoriasis

Mast cells as important regulators in the development of psoriasis

Lupeol alleviates atopic dermatitis-like skin inflammation in 2,4-dinitrochlorobenzene/Dermatophagoides farinae extract-induced mice

Effect of Sopoongsan on Skin Inflammation and Hyperlocomotion in Socially Isolated Mice with Atopic Dermatitis

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