Crosstalk between GH/IGF-I axis and steroid hormones (progesterone, 17β-estradiol) in canine mammary tumours

Queiroga, Felisbina L.; Alenza, María Dolores Pérez; Silván, Gema; Peña, Laura; Lopes, Carlos; Illera, Juan Carlos

doi:10.1016/j.jsbmb.2008.02.005

Cited by 41 publications

(53 citation statements)

References 55 publications

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“…In canine mammary carcinoma, tissue IGF-1 has been positively correlated with tumour malignancy, as well as with tissue levels of progesterone and 17β-estradiol (18). The highest levels of IGF-1 have been observed in the most aggressive types of tumours.…”

Section: Tab 1 Mean ± Sd Concentration Of Igf-1 In Blood Plasma Of mentioning

confidence: 96%

“…In the last years serum IGF-1 levels have also been studied in various aspects in dogs (3,18,29). The implication of the GH/IGF-1 axis in canine mammary tumours has been recently demonstrated (7,18,19).…”

Section: Praca Oryginalnamentioning

confidence: 99%

“…The implication of the GH/IGF-1 axis in canine mammary tumours has been recently demonstrated (7,18,19). However, studies concerning the serum IGF-1 levels in dogs with mammary tumours are scarce (19).…”

Section: Praca Oryginalnamentioning

confidence: 99%

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Circulating concentrations of insulin like growth factor-1 in female dogs with spontane-ous mammary tumours

Szczubiał¹,

Dąbrowski²,

Łopuszyński³

et al. 2018

Medycyna Weterynaryjna

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SummaryThe aim of this study was the investigation of the circulating concentration of IGF-1 in female dogs with spontaneous mammary tumours. The study was performed on 34 female dogs undergoing surgery due to spontaneously occurring mammary gland tumours (24 malignant and 10 benign) and 10 clinically healthy female dogs. The serum concentrations of IGF-1 were determined by specific ELISA Kit assay. The mean concentrations of IGF-1 were significantly higher (P < 0.05) both in dogs with malignant (173.35 ± 120.45 ng/ml) and benign (130.58 ± 59.0 ng/ml) mammary tumours than in healthy controls (117.45 ± 71.0 ng/ml). In the group of female dogs with mammary carcinomas, the mean concentration of IGF-1 gradually increased from 132.85 ± 65.64 ng/ml in dogs with grade 1 tumours to 317.74 ± 119.25 ng/ml in those with grade 3 tumours, and significant differences (P < 0.05) were found among dogs with various grade tumours. These findings suggest that circulating IGF-1 may play an important role in the pathogenesis of canine mammary tumour. Moreover, high IGF-1 levels may reflect tumour cell differentiation into a more aggressive phenotype.

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Section: Tab 1 Mean ± Sd Concentration Of Igf-1 In Blood Plasma Of mentioning

confidence: 96%

Section: Praca Oryginalnamentioning

confidence: 99%

See 1 more Smart Citation

Circulating concentrations of insulin like growth factor-1 in female dogs with spontane-ous mammary tumours

Szczubiał¹,

Dąbrowski²,

Łopuszyński³

et al. 2018

Medycyna Weterynaryjna

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“…Endogenous progesterone or exogenous progestins stimulate GH production in hyperplastic mammary glands in dogs [6,12,13]. This GH can act via the autocrine system to promote the growth of mammary glands or elevate systemic IGF-I secretion [10]. Excessive GH also induces glucose intolerance, which can lead to hyperinsulinemia and/or hyperglycemia.…”

mentioning

confidence: 99%

“…Anemia has been reported in dogs with acromegaly or dogs treated with porcine GH. However, the exact mechanism causing anemia with these dogs remains unknown [10].…”

mentioning

confidence: 99%

GH-Producing Mammary Tumors in Two Dogs with Acromegaly

Murai

Nishii

Morita

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. Two intact female dogs were admitted for growing mammary tumors. They had symptoms of acromegaly including weight gain, enlargement of the head, excessive skin folds, and inspiratory stridor. Serum concentrations of growth hormone (GH), insulinlike growth factor-I (IGF-I), and insulin were elevated in the two cases. From these findings, both dogs were diagnosed with acromegaly. In case 1, the GH, IGF-I, and insulin levels subsided after removal of the focal benign mammary tumors and ovariohysterectomy. In case 2, those levels subsided after removal of only focal mammary carcinoma. In both cases, immunohistochemical investigations for GH were positive in the mammary tumor cells but not in the normal mammary glands. We concluded that GH-producing mammary tumors caused the present acromegaly.

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