Crosstalk between ferroptosis and steroid hormone signaling in gynecologic cancers

Abstract

Ferroptosis is a novel types of regulated cell death and is widely studied in cancers and many other diseases in recent years. It is characterized by iron accumulation and intense lipid peroxidation that ultimately inducing oxidative damage. So far, signaling pathways related to ferroptosis are involved in all aspects of determining cell fate, including oxidative phosphorylation, metal-ion transport, energy metabolism and cholesterol synthesis progress, et al. Recently, accumulated studies have demonstrated that ferroptosis is associated with gynecological oncology related to steroid hormone signaling. This review trends to summarize the mechanisms and applications of ferroptosis in cancers related to estrogen and progesterone, which is expected to provide a theoretical basis for the prevention and treatment of gynecologic cancers.

Oxysterol 25-hydroxycholesterol activation of ferritinophagy inhibits the development of squamous intraepithelial lesion of cervix in HPV-positive patients

“…Here, our study reveals the relationship between 25-HC and the regulation of iron homeostasis in cervical tissues. The induction of ferroptosis can be divided into two main pathway: the extrinsic pathway, which is related to cystine/glutamic acid transport (system xc − ) and iron uptake (including TFRC, NCOA4, ferritin components); the intrinsic pathway, which is related to antioxidant enzyme (including unsaturation fatty acid pathway, MVA pathway related to cholesterol biosynthesis, transsulfuration progress, AIFM2-CoQ10 axis, and GCH1-BH4 pathway, et al) [ 28 ]. Oxysterols, which are cholesterol metabolites, have been reported to regulate ferroptosis.…”