2021
DOI: 10.14814/phy2.14958
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Crosstalk between beta‐adrenergic and insulin signaling mediates mechanistic target of rapamycin hyperactivation in liver of high‐fat diet‐fed male mice

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Cited by 4 publications
(2 citation statements)
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References 91 publications
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“…Similarly, an autonomic imbalance due to increased sympathetic activation is a cause of liver dysfunction [25,32]. Chronic activation of sympathetic nerves reaching the liver leads to increased gluconeogenesis and lipogenesis, thus increasing lipid accumulation and liver steatosis [33,34]. This evidence is supported by the fact that liver denervation reduces liver steatosis and improves NAFLD [33].…”
Section: Discussionmentioning
confidence: 95%
“…Similarly, an autonomic imbalance due to increased sympathetic activation is a cause of liver dysfunction [25,32]. Chronic activation of sympathetic nerves reaching the liver leads to increased gluconeogenesis and lipogenesis, thus increasing lipid accumulation and liver steatosis [33,34]. This evidence is supported by the fact that liver denervation reduces liver steatosis and improves NAFLD [33].…”
Section: Discussionmentioning
confidence: 95%
“…In addition, β-AR showed regulation of glucose uptake and glycogen synthesis (7). β1-AR agonists reduced insulin-induced glucose uptake and glycogen synthesis (8). Glycogen storage in cardiomyocytes has been shown to be related with myocardial hypertrophy.…”
Section: Introductionmentioning
confidence: 99%