Crosstalk Among YAP, LncRNA, and Tumor-Associated Macrophages in Tumorigenesis Development

Xu, Jing; Liu, Xinyuan; Zhang, Qi; Liu, Hua; Zhang, Peng; Tian, Zibin; Zhang, Cuiping; Li, Xiaoyü

doi:10.3389/fonc.2021.810893

Cited by 9 publications

(9 citation statements)

References 89 publications

(88 reference statements)

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“…Furthermore, the interaction between B4GALT1-AS1 and miR-144-3p regulated ZEB1 expression and increased the progression and tumorigenesis of the NSCLC cell line [29]. Further studies highlighted that the function of B4GALT1-AS1 was associated, at least partly, with two key proteins, HuR and YAP, which have been identi ed to provide roles in the development of cancers [30]. YAP-associated protein (YAP) is a prolin -rich phosphoprotein encoded by the yap1 gene [31] and is a member of the hippo pathway.…”

Section: Discussionmentioning

confidence: 98%

Downregulation of long noncoding RNA B4GALT1-AS1 is associated with Breast Cancer development

ahvaz,

Amini,

Yari

et al. 2023

Preprint

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The misregulation of long noncoding RNAs (lncRNAs) is related to the progressive evolution of various human cancers, such as Breast cancer (BC). The role of lncRNA B4GALT1-AS1 has been investigated in some human cancers. Therefore, studying B4GALT1-AS1 expression was aimed for the first time in the tumor and marginal tissues of BC in this study. The cancer genome atlas (TCGA) database was utilized to evaluate the relative expression of B4GALT1-AS1 in BC and other cancers. RNA was extracted from twenty-eight paired BC and marginal tissues and cDNA was synthesized. The quantitative expression level of B4GALT1-AS1 was evaluated using real-time PCR. The bioinformatics analyses were performed to identify co-expression genes and related pathways. B4GALT1-AS1 was significantly downregulated in BC specimens compared to tumor marginal samples. The TCGA data analysis confirmed the downregulation of B4GALT1-AS1 in BC. The bioinformatics analysis discovered the correlation between 700 genes and B4GALT1-AS1 and identified GNAI1 as the high degree gene which was positively correlated with B4GALT1-AS1 expression. It seems B4GALT1-AS1 provides its function, at least partly, in associated with one of the hippo pathway components, YAP, in other cancers. This protein has the opposite role in BC and its loss of function can result in the poor survival in BC. Further researches are needed to investigate the interaction between B4GALT1‐AS1 and YAP in various subtypes of BC.

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Section: Discussionmentioning

confidence: 98%

Downregulation of long noncoding RNA B4GALT1-AS1 is associated with Breast Cancer development

ahvaz,

Amini,

Yari

et al. 2023

Preprint

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show abstract

“…Yes‐associated protein (YAP), lncRNA, and TAM are closely related, and their individuality and interaction are significantly meaningful for tumorigenesis, metastasis, treatment, and prognosis 139 . Nogo‐B is widely expressed in most tissues and is the only subtype of the family expressed in the liver.…”

Section: Signaling Pathway/axis Involved In Hcc Via Tamsmentioning

confidence: 99%

The role of tumor‐associated macrophages in hepatocellular carcinoma progression: A narrative review

Zhang,

Yu,

Zhao

et al. 2023

Cancer Medicine

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, with complex etiology and mechanism, and a high mortality rate. Tumor‐associated macrophages (TAMs) are an important part of the HCC tumor microenvironment. Studies in recent years have shown that TAMs are involved in multiple stages of HCC and are related to treatment and prognosis in HCC. The specific mechanisms between TAMs and HCC are gradually being revealed. This paper reviews recent advances in the mechanisms associated with TAMs in HCC, concentrating on an overview of effects of TAMs on drug resistance in HCC and the signaling pathways linked with HCC, providing clues for the treatment and prognosis determination of HCC.

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“…Upon activation, MST1/2 kinase is phosphorylated and forms a complex with SAV1 to phosphorylate LATS1/2, which in turn phosphorylates the transcriptional co-activator YAP. The phosphorated YAP binds to the 14-3-3 proteins and is retained in the cytoplasm or is degraded by the ubiquitin-proteasome pathway [ 49 ]. In the absence of an active Hippo signaling pathway, unphosphorylated Yap and Taz enter the nucleus, interact with the transcription factors, and stimulate the expression of genes involved in proliferation and anti-apoptotic processes.…”

Section: Lncrnas-regulated Pathways In Cervical Cancermentioning

confidence: 99%

The Regulatory Functions and the Mechanisms of Long Non-Coding RNAs in Cervical Cancer

Yang

Al-Hendy

2022

Cells

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Cervical cancer is one of the leading causes of death in gynecology cancer worldwide. High-risk human papillomaviruses (HPVs) are the major etiological agents for cervical cancer. Still, other factors also contribute to cervical cancer development because these cancers commonly arise decades after initial exposure to HPV. So far, the molecular mechanisms underlying the pathogenesis of cervical cancer are still quite limited, and a knowledge gap needs to be filled to help develop novel strategies that will ultimately facilitate the development of therapies and improve cervical cancer patient outcomes. Long non-coding RNAs (lncRNAs) have been increasingly shown to be involved in gene regulation, and the relevant role of lncRNAs in cervical cancer has recently been investigated. In this review, we summarize the recent progress of ascertaining the biological functions of lncRNAs in cervical cancer, from the perspective of cervical cancer proliferation, invasion, and metastasis. In addition, we provide the current state of knowledge by discussing the molecular mechanisms underlying the regulation and emerging role of lncRNAs in the pathogenesis of cervical cancer. Comprehensive and deeper insights into lncRNA-mediated alterations and interactions in cellular events will help develop novel strategies to treat patients with cervical cancer.

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Crosstalk Among YAP, LncRNA, and Tumor-Associated Macrophages in Tumorigenesis Development

Cited by 9 publications

References 89 publications

Downregulation of long noncoding RNA B4GALT1-AS1 is associated with Breast Cancer development

Downregulation of long noncoding RNA B4GALT1-AS1 is associated with Breast Cancer development

The role of tumor‐associated macrophages in hepatocellular carcinoma progression: A narrative review

The Regulatory Functions and the Mechanisms of Long Non-Coding RNAs in Cervical Cancer

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