Crosstalk Among Glial Cells in the Blood–Brain Barrier Injury After Ischemic Stroke

Lu, Weizhuo; Wen, Jiyue

doi:10.1007/s12035-024-03939-6

Cited by 2 publications

(1 citation statement)

References 157 publications

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“…These roles are critical for maintaining the integrity of the BBB and supporting neural activity. 79 , 80 When the CNS is stimulated by injury, astrocytes will be in an activated state. Their number, morphology and biological function may change from resting astrocytes to reactive astrocytes.…”

Section: How Effective Is Neural Stem Cell Therapy For Ischemic Strokementioning

confidence: 99%

Neural Stem Cell-Derived Small Extracellular Vesicles: key Players in Ischemic Stroke Therapy – A Comprehensive Literature Review

Zhu,

Zhang,

Feng

et al. 2024

IJN

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Ischemic stroke, being a prominent contributor to global disability and mortality, lacks an efficacious therapeutic approach in current clinical settings. Neural stem cells (NSCs) are a type of stem cell that are only found inside the nervous system. These cells can differentiate into various kinds of cells, potentially regenerating or restoring neural networks within areas of the brain that have been destroyed. This review begins by providing an introduction to the existing therapeutic approaches for ischemic stroke, followed by an examination of the promise and limits associated with the utilization of NSCs for the treatment of ischemic stroke. Subsequently, a comprehensive overview was conducted to synthesize the existing literature on the underlying processes of neural stem cell-derived small extracellular vesicles (NSC-sEVs) transplantation therapy in the context of ischemic stroke. These mechanisms encompass neuroprotection, inflammatory response suppression, and endogenous nerve and vascular regeneration facilitation. Nevertheless, the clinical translation of NSC-sEVs is hindered by challenges such as inadequate targeting efficacy and insufficient content loading. In light of these limitations, we have compiled an overview of the advancements in utilizing modified NSC-sEVs for treating ischemic stroke based on current methods of extracellular vesicle modification. In conclusion, examining NSC-sEVs-based therapeutic approaches is anticipated to be prominent in both fundamental and applied investigations about ischemic stroke.

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Section: How Effective Is Neural Stem Cell Therapy For Ischemic Strokementioning

confidence: 99%

Neural Stem Cell-Derived Small Extracellular Vesicles: key Players in Ischemic Stroke Therapy – A Comprehensive Literature Review

Zhu,

Zhang,

Feng

et al. 2024

IJN

View full text Add to dashboard Cite

show abstract

Astragaloside IV promotes cerebral tissue restoration through activating AMPK- mediated microglia polarization in ischemic stroke rats

Li,

Jia,

Wang

et al. 2024

Journal of Ethnopharmacology

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Crosstalk Among Glial Cells in the Blood–Brain Barrier Injury After Ischemic Stroke

Cited by 2 publications

References 157 publications

Neural Stem Cell-Derived Small Extracellular Vesicles: key Players in Ischemic Stroke Therapy – A Comprehensive Literature Review

Neural Stem Cell-Derived Small Extracellular Vesicles: key Players in Ischemic Stroke Therapy – A Comprehensive Literature Review

Astragaloside IV promotes cerebral tissue restoration through activating AMPK- mediated microglia polarization in ischemic stroke rats

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