Crossreactivity of Human Anti-dsDNA Antibodies to Phosphorylcholine: Clues to Their Origin

Sharma, Arti; Isenberg, David; Diamond, Betty

doi:10.1006/jaut.2001.0514

Cited by 29 publications

(23 citation statements)

References 19 publications

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“…IgG antibodies, dsDNA itself, and complement components are deposited in the glomeruli of SLE patients. Circulating immune complexes of IgG and dsDNA appear to have a high affinity to the basement membrane [11,12].…”

Section: Introductionmentioning

confidence: 98%

IgM Antibodies Against dsDNA in SLE

Witte¹

2007

Clinic Rev Allerg Immunol

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IgG antibodies against dsDNA are involved in the pathogenesis of systemic lupus erythematosus (SLE) glomerulonephritis. In contrast, glomerulonephritis is rare in SLE patients with IgM antibodies against dsDNA. Therefore, a possible protective effect of IgM antibodies has been studied in more detail. In murine models of SLE, the lack of secreted IgM was associated with more severe glomerulonephritis. In more recent studies, the treatment of lupus-prone mice with a murine IgM monoclonal antibody against dsDNA prevented renal damage. Furthermore, the clearance of pathogenic immune complexes may be improved by IgM. Therefore, IgM antibodies against dsDNA are indeed protective and may be a new treatment modality of lupus nephritis in humans.

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Section: Introductionmentioning

confidence: 98%

IgM Antibodies Against dsDNA in SLE

Witte¹

2007

Clinic Rev Allerg Immunol

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“…An explanation may be that human IgG anti-PTC are hidden by PTC itself [23], and/or that IgM anti-PTC is masked by its IgG counterpart [24], both as control mechanism(s) of autoreactivity. Sharma et al recently reported that IgG anti-dsDNA from systemic lupus erythematosus patients crossreact with phosphorylcholine [25]. We report here that the anti-dsDNA activity displayed by IgM anti-PTC could be inhibited by mPTC.…”

Section: Discussionmentioning

confidence: 49%

Characterization of Anti-Phosphatidylcholine Polyreactive Natural Autoantibodies from Normal Human Subjects

Cabiedes

Cabral

López-Mendoza

et al. 2002

Journal of Autoimmunity

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“…In this regard, it is worth noting that polyclonal anti-dsDNA antibodies purified from SLE sera often crossreact with phosphorylcholine. 21 Some other examples of peptides that mimic DNA have also been reported. Fig.…”

Section: Molecular Mimicry And/or Cross-reactionmentioning

confidence: 95%

Mechanisms of anti-DNA antibody production

Kubota

2002

Modern Rheumatology

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The nucleosome has attracted attention because it is a possible primary antigen that initiates autoimmune reactions and also seems to play a key role in glomerular injury in systemic lupus erythematosus (SLE). It is not immunogenic in nonautoimmune individuals, however, and many other protein or peptide antigens inducing anti-DNA antibodies in normal animals have been reported recently. Various mechanisms have been proposed to account for this, including idiotype-anti-idiotype, hapten-carrier, molecular mimicry, and others. In addition to the initial immune responses to such antigens, breakdown of selftolerance influenced by genetic factors or hormonal dysregulation may be necessary preconditions for occurrence of the disease.

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Crossreactivity of Human Anti-dsDNA Antibodies to Phosphorylcholine: Clues to Their Origin

Cited by 29 publications

References 19 publications

IgM Antibodies Against dsDNA in SLE

IgM Antibodies Against dsDNA in SLE

Characterization of Anti-Phosphatidylcholine Polyreactive Natural Autoantibodies from Normal Human Subjects

Mechanisms of anti-DNA antibody production

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