Crossreaction between antibodies to oxidised low-density lipoprotein and to cardiolipin in systemic lupus erythematosus

Vaarala, Outi; Aho, Kimmo; Palosuo, Timo; Alfthan, Georg; Jauhiainen, Matti; Leirisalo‐Repo, Marjatta

doi:10.1016/0140-6736(93)91213-6

Cited by 366 publications

(210 citation statements)

References 8 publications

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“…Cross-reactions between antibodies to oxidized LDLs and cardiolipins have been described in SLE from as early as 1993 (9). In our study, we found that aCL IgM levels had a statistically significant relationship with LDL levels.…”

Section: Discussionsupporting

confidence: 71%

Dyslipidemia and its relationship with antiphospholipid antibodies in APS patients in North Kerala

et al. 2017

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Section: Discussionsupporting

confidence: 71%

Dyslipidemia and its relationship with antiphospholipid antibodies in APS patients in North Kerala

et al. 2017

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“…Plasma EC-SOD and autoantibodies against oxidized (ox)LDL were determined in duplicate by means of enzyme-linked immunosorbent assays, as previously described. 8,9 Plasma samples were stored at Ϫ80°C until analyzed. Coefficients of variation on duplicate measurements were 4% for plasma EC-SOD and 17% for autoantibodies against oxLDL.…”

Section: Other Analysesmentioning

confidence: 99%

Genetically Reduced Antioxidative Protection and Increased Ischemic Heart Disease Risk

et al. 2004

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Background-Extracellular superoxide dismutase (EC-SOD) is an antioxidative enzyme found in high concentrations in the arterial wall. Two to three percent of all people in Denmark carry an R213G substitution, which increases plasma concentration 10-fold. This may reduce arterial wall EC-SOD concentrations, increase intimal LDL oxidation, and therefore may accelerate atherogenesis. Our primary hypothesis was that EC-SOD-R213G predisposes to ischemic heart disease (IHD). The secondary hypothesis was that EC-SOD-R213G offers predictive ability with respect to IHD beyond that offered by measurements of plasma EC-SOD and autoantibodies against oxidized LDL (oxLDL). Methods and Results-The primary hypothesis was tested in a prospective, population-based study of 9188 participants from The Copenhagen City Heart Study with 956 incident IHD events during 23 years of follow-up and retested cross-sectionally with independent case populations of patients with IHD (nϭ943) or ischemic cerebrovascular disease (ICVD) (nϭ617). Case populations were compared with unmatched IHD/ICVD-free control subjects from The Copenhagen City Heart Study (nϭ7992). The secondary hypothesis was tested by using a nested case-control study comparing patients with IHD (nϭ956) with age-and gender-matched control subjects (nϭ956). Age-and genderadjusted relative risk for IHD in heterozygotes (nϭ221, 2.4%) versus noncarriers (nϭ8965, 97.6%) was 1.5 (95% CI, 1.1 to 2.1). Retesting confirmed this: Age-and gender-adjusted odds ratios for IHD was 1.4 (1.0 to 2.0) and for ICVD 1.7 (1.1 to 2.7). Additional adjustment for plasma EC-SOD produced an odds ratio for IHD in heterozygotes versus noncarriers of 9.2 (1.2 to 72), whereas adjustment for autoantibodies against oxLDL produced an odds ratio of 2.5 (1.2 to 5.3). Conclusions-Heterozygosity for EC-SOD-R213G is associated with increased IHD risk. Genotyping offers predictive ability with respect to IHD beyond that offered by plasma EC-SOD and autoantibodies against oxLDL.

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“…Anticardiolipin antibodies, a hallmark of the antiphospho-lipid antibody syndrome (APS), can also be found in a wide range of different conditions and are present in 30-40% of patients with SLE (8). Cross-reactivity between these autoantibodies and plasma lipoproteins, particularly when the latter are oxidized, has been described to occur in SLE and APS and could contribute to the increased risk of atherosclerosis found in both conditions (9). Oxidation is a major process in atherosclerosis (10), and oxidative stress has been described in both SLE and APS (11).…”

mentioning

confidence: 99%

Antibodies to high‐density lipoprotein and β₂‐glycoprotein I are inversely correlated with paraoxonase activity in systemic lupus erythematosus and primary antiphospholipid syndrome

Alves

Ames

Donohue

et al. 2002

Arthritis & Rheumatism

185

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Objective. To determine the prevalence of antihigh-density lipoprotein (anti-HDL) antibodies and to establish a possible relationship between anti-HDL, anticardiolipin antibodies (aCL), anti-␤ 2 -glycoprotein I (anti-␤ 2 GPI), and paraoxonase (PON) activity in patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS).Methods. Thirty-two patients with SLE and 36 with primary APS were enrolled in a cross-sectional study. Twenty age-and sex-matched healthy subjects were used as controls. Serum levels of IgG and IgM aCL, anti-␤ 2 GPI, and antiprothrombin antibodies and IgG anti-HDL were measured by enzyme-linked immunosorbent assay. Total cholesterol, HDL cholesterol, HDL 2 , and HDL 3 were determined by standard enzymatic techniques. PON activity was assessed by quantification of nitrophenol formation, and total antioxidant capacity (TAC) by chemiluminescence.Results. Levels of total HDL, HDL 2 , and HDL 3 were reduced in patients with SLE compared with controls (mean ؎ SD 0.51 ؎ 0.3, 0.37 ؎ 0.3, and 0.14 ؎ 0.1 mmoles/liter, respectively, versus 1.42 ؎ 0.9, 1.01 ؎ 0.7, and 0.40 ؎ 0.2). Patients with SLE and primary APS had higher titers of anti-HDL antibodies and lower PON activity than controls. In the SLE population, PON activity was inversely correlated with IgG anti-HDL titers (r ‫؍‬ ؊0.48, P ‫؍‬ 0.005) whereas in the primary APS population, IgG anti-␤ 2 GPI was the only independent predictor of PON activity (r ‫؍‬ ؊0.483, P ‫؍‬ 0.003). In the SLE group, anti-HDL was inversely correlated with TAC (r ‫؍‬ ؊0.40, P < 0.02), and PON activity was positively correlated with TAC (r ‫؍‬ 0.43, P < 0.02).Conclusion. IgG anti-HDL and IgG anti-␤ 2 GPI antibodies are associated with reduced PON activity in patients with SLE and primary APS. Since the physiologic role of PON is to prevent low-density lipoprotein oxidation with its attendant atherogenic effects, the reported interactions may be relevant to the development of atherosclerosis in SLE and primary APS.

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Crossreaction between antibodies to oxidised low-density lipoprotein and to cardiolipin in systemic lupus erythematosus

Cited by 366 publications

References 8 publications

Dyslipidemia and its relationship with antiphospholipid antibodies in APS patients in North Kerala

Dyslipidemia and its relationship with antiphospholipid antibodies in APS patients in North Kerala

Genetically Reduced Antioxidative Protection and Increased Ischemic Heart Disease Risk

Antibodies to high‐density lipoprotein and β₂‐glycoprotein I are inversely correlated with paraoxonase activity in systemic lupus erythematosus and primary antiphospholipid syndrome

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Crossreaction between antibodies to oxidised low-density lipoprotein and to cardiolipin in systemic lupus erythematosus

Cited by 366 publications

References 8 publications

Dyslipidemia and its relationship with antiphospholipid antibodies in APS patients in North Kerala

Dyslipidemia and its relationship with antiphospholipid antibodies in APS patients in North Kerala

Genetically Reduced Antioxidative Protection and Increased Ischemic Heart Disease Risk

Antibodies to high‐density lipoprotein and β2‐glycoprotein I are inversely correlated with paraoxonase activity in systemic lupus erythematosus and primary antiphospholipid syndrome

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Antibodies to high‐density lipoprotein and β₂‐glycoprotein I are inversely correlated with paraoxonase activity in systemic lupus erythematosus and primary antiphospholipid syndrome