Crossover regime for the diffusion of nanoparticles in polyethylene glycol solutions: influence of the depletion layer

Ziębacz, Natalia; Wieczorek, Stefan A.; Kalwarczyk, Tomasz; Fiałkowski, Marcin; Hołyst, Robert

doi:10.1039/c0sm01357a

Cited by 98 publications

(127 citation statements)

References 27 publications

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“…Active research in this field is beneficial for control of anomalous subdiffusion in biological media, calibration of measurements by use of fluorescence correlation spectroscopy (FCS) and analysis of single particle tracking within the dense environment of the cell [1,3,8]. It is expected also to contribute to further progress in a general theory [13][14][15] of the anisotropic motion of objects in entangled suspensions responsible for steric effects.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, diffusion of silica tracer beads with large radii through colloidal rods have been observed experimentally to depend on the rod density, exhibiting domination of caging effects at high densities of rods. Similar experiments with apoferritin, quantum dots and lysozyme [8] diffusing in poly(ethylene glycol) solutions have been analyzed addressing a connection between the motion of nanoscopic probes in polymer solutions and their macroviscosity. Diffusion of spherical tracers through a liquid crystal consisting of ellipsoidal particles near the isotropic-nematic phase transitions has been investigated theoretically [12] pointing to the increasing anisotropy of the probe dynamics with increasing long-range order of nematogens.…”

Section: Introductionmentioning

confidence: 99%

“…Effects of the entrapment within the mesh composed of the obstacles and elucidation of dynamical behavior of spherical tracers diffusing through the collective structure of scatterers have been investigated so far both experimentally [8,9] and theoretically [1,[10][11][12][13][14]. In particular, diffusion of silica tracer beads with large radii through colloidal rods have been observed experimentally to depend on the rod density, exhibiting domination of caging effects at high densities of rods.…”

Section: Introductionmentioning

confidence: 99%

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Tracer diffusion inside fibrinogen layers

Cieśla

Gudowska–Nowak

Sagués

et al. 2014

The Journal of Chemical Physics

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We investigate the obstructed motion of tracer (test) particles in crowded environments by carrying simulations of two-dimensional Gaussian random walk in model fibrinogen monolayers of different orientational ordering. The fibrinogen molecules are significantly anisotropic and therefore they can form structures where orientational ordering, similar to the one observed in nematic liquid crystals, appears. The work focuses on the dependence between level of the orientational order (degree of environmental crowding) of fibrinogen molecules inside a layer and non-Fickian character of the diffusion process of spherical tracer particles moving within the domain. It is shown that in general particles motion is subdiffusive and strongly anisotropic, and its characteristic features significantly change with the orientational order parameter, concentration of fibrinogens and radius of a diffusing probe.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tracer diffusion inside fibrinogen layers

Cieśla

Gudowska–Nowak

Sagués

et al. 2014

The Journal of Chemical Physics

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“…Another model based on walking confined diffusion often assumes that there is a depletion layer (containing solvent molecules such as water) between NPs and polymers. 35 This model can describe some fast diffusion observed in short-time stage (as shown in Figure 1a where short-time MSD presents larger values). Our measured DPD does not support this model either.…”

Section: The Journal Of Physical Chemistry Lettersmentioning

confidence: 99%

“…8,22,32 However, there are several important questions that MSD results are unable to answer. First, as explained by Piskorz and Ochab-Marcinek, 13 all those commonly used models (i.e., elastic force, 27,33,34 walking confined diffusion with depletion layer, 35,36 or hopping diffusion 8,37,38 ) predict the same MSD feature as shown in Figure 1. It is necessary to develop an alternative approach to identify the source of non-Gaussian behavior and unveil the mechanism of the interaction between the NP and surrounding structure.…”

mentioning

confidence: 99%

Probing Non-Gaussianity in Confined Diffusion of Nanoparticles

Xue

Zheng

Chen

et al. 2016

J. Phys. Chem. Lett.

116

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Confined diffusion is ubiquitous in nature. Ever since the “anomalous yet Brownian” motion was observed, the non-Gaussianity in confined diffusion has been unveiled as an important issue. In this Letter, we experimentally investigate the characteristics and source of non-Gaussian behavior in confined diffusion of nanoparticles suspended in polymer solutions. A time-varied and size-dependent non-Gaussianity is reported based on the non-Gaussian parameter and displacement probability distribution, especially when the nanoparticle’s size is smaller than the typical polymer mesh size. This non-Gaussianity does not vanish even at the long-time Brownian stage. By inspecting the displacement autocorrelation, we observe that the nanoparticle–structure interaction, indicated by the anticorrelation, is limited in the short-time stage and makes little contribution to the non-Gaussianity in the long-time stage. The main source of the non-Gaussianity can therefore be attributed to hopping diffusion that results in an exponential probability distribution with the large displacements, which may also explain certain processes dominated by rare events in the biological environment.

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Water‐in‐Water Droplets Selectively Uptake Self‐Assembled DNA Nano/Microstructures: a Versatile Method for Purification in DNA Nanotechnology

Masukawa

Sato

et al. 2022

ChemBioChem

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DNA is an excellent material for constructing self-assembled nano/microstructures. Owing to the widespread use of DNA as a building block in laboratories and industry, it is desirable to increase the efficiency of all steps involved in producing selfassembled DNA structures. One of the bottlenecks is the purification required to separate the excess components from the target structures. This paper describes a purification method based on the fractionation by water-in-water (W/W) droplets composed of phase-separated dextran-rich droplets in a polyethylene glycol (PEG)-rich continuous phase. The dextran-rich droplets facilitate the selective uptake of self-assembled DNA nano/microstructures and allow the separation of the target structure. This study investigates the ability to purify DNA origami, DNA hydrogels, and DNA microtubes. The W/W-droplet fractionation allows the purification of structures of a broad size spectrum without changes to the protocol. By quantifying the activity of deoxyribozyme-modified DNA origami after W/Wdroplet purification, this study demonstrates that this method sufficiently preserves the accessibility to the surface of a functional DNA nanostructure. It is considered that the W/Wdroplet fractionation could become one of the standard methods for the purification of self-assembled DNA nano/ microstructures for biomedical and nanotechnology applications owing to its low cost and simplicity.

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Crossover regime for the diffusion of nanoparticles in polyethylene glycol solutions: influence of the depletion layer

Cited by 98 publications

References 27 publications

Tracer diffusion inside fibrinogen layers

Tracer diffusion inside fibrinogen layers

Probing Non-Gaussianity in Confined Diffusion of Nanoparticles

Water‐in‐Water Droplets Selectively Uptake Self‐Assembled DNA Nano/Microstructures: a Versatile Method for Purification in DNA Nanotechnology

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