Crossover interference

Hillers, Kenneth J.

doi:10.1016/j.cub.2004.11.038

Cited by 110 publications

(98 citation statements)

References 5 publications

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“…At the intermediate scale, conclusions are more vague. Regional recombination is decidedly influenced by crossover interference, where a crossover in one location prevents another crossover from occurring close by (Foss et al, 1993;Hillers, 2004;Stahl et al, 2004;Copenhaver, 2005). Regional properties of chromosomes have an impact as well, clearly shown by the lack of crossovers in the centromeric region and typically a high number of crossovers near the telomeres.…”

Section: How Does the Methodology By Which Recombination Is Measured mentioning

confidence: 99%

Recombination rate variation in closely related species

2011

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Despite their importance to successful meiosis and various evolutionary processes, meiotic recombination rates sometimes vary within species or between closely related species. For example, humans and chimpanzees share virtually no recombination hotspot locations in the surveyed portion of the genomes. However, conservation of recombination rates between closely related species has also been documented, raising an apparent contradiction. Here, we evaluate how and why conflicting patterns of recombination rate conservation and divergence may be observed, with particular emphasis on features that affect recombination, and the scale and method with which recombination is surveyed. Additionally, we review recent studies identifying features influencing fine-scale and broad-scale recombination patterns and informing how quickly recombination rates evolve, how changes in recombination impact selection and evolution in natural populations, and more broadly, which forces influence genome evolution.

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Section: How Does the Methodology By Which Recombination Is Measured mentioning

confidence: 99%

Recombination rate variation in closely related species

2011

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“…The cell balances these costs and benefits by tightly regulating meiotic recombination, including the imposition of CO interference in most organisms. There is surprising diversity in the execution and regulation of meiotic recombination in different organisms, ranging from utilization of different protein components to divergence in the use of entire regulatory pathways, such as interference mechanisms (3,4). Because of this diversity, researchers use a variety of model systems to study meiosis, including fungi, plants, insects, nematodes, and mammals.…”

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Pollen tetrad-based visual assay for meiotic recombination in Arabidopsis

Francis

Lam²,

Harrison³

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

180

197

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Recombination, in the form of cross-overs (COs) and gene conversion (GC), is a highly conserved feature of meiosis from fungi to mammals. Recombination helps ensure chromosome segregation and promotes allelic diversity. Lesions in the recombination machinery are often catastrophic for meiosis, resulting in sterility. We have developed a visual assay capable of detecting Cos and GCs and measuring CO interference in Arabidopsis thaliana. This flexible assay utilizes transgene constructs encoding pollen-expressed fluorescent proteins of three different colors in the qrt1 mutant background. By observing the segregation of the fluorescent alleles in 92,489 pollen tetrads, we demonstrate (i) a correlation between developmental position and CO frequency, (ii) a temperature dependence for CO frequency, (iii) the ability to detect meiotic GC events, and (iv) the ability to rapidly assess CO interference.cross-over ͉ meiosis ͉ tetrad ͉ gene conversion ͉ interference

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“…In some species, e.g. Caenorhabditis, interference may cover an entire chromosome, so that only a single crossover can occur per chromosome (Hillers, 2004). How does interference spread along the chromosome, and are TF proteins required for this?…”

Section: What Do Tf Proteins Do?mentioning

confidence: 99%

Meiotic Transverse Filament Proteins: Essential for Crossing Over

Heyting

2005

Transgenic Res

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Meiosis is a specialized set of two nuclear divisions, meiosis I and II, by which a diploid cell produces four haploid daughters. After premeiotic DNA replication, homologous chromosomes pair and recombine, and then disjoin at meiosis I. Subsequently, at meiosis II, the sister chromatids of each chromosome segregate. In nearly all eukaryotes, meiotic chromosome pairing culminates in the formation of a ladderlike supramolecular protein structure, the synaptonemal complex (SC) (Page and Hawley, 2004). The rungs of the ladder are known as transverse filaments (TFs). Genes encoding TF proteins have been identified in a limited number of organisms, and their function has been studied by mutational analysis. Although TF proteins show little amino acid sequence conservation, their structure and function are largely conserved. In all analyzed species, TF proteins are required for meiotic reciprocal recombination (crossing over).

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Crossover interference

Cited by 110 publications

References 5 publications

Recombination rate variation in closely related species

Recombination rate variation in closely related species

Pollen tetrad-based visual assay for meiotic recombination in Arabidopsis

Meiotic Transverse Filament Proteins: Essential for Crossing Over

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