Crosslinking of the electrospun gelatin nanofibers

Zhang, Yanzhong; Venugopal, Jayarama Reddy; Huang, Zheng‐Ming; Lim, Chwee Teck; Ramakrishna, Seeram

doi:10.1016/j.polymer.2006.02.046

Cited by 576 publications

(456 citation statements)

References 33 publications

Supporting

Mentioning

440

Contrasting

Order By: Relevance

“…Since gelatin is a water soluble material, as-spun fiber membranes will partially or totally dissolve when in contact with an aqueous medium or high moisture environments [12]. To broaden the applications of these gelatin fibers to procedures requiring contact with water or biological medium gelatin fibers were exposed to a saturated atmosphere of GA in order to promote chemical cross-linking of the material.…”

Section: Resultsmentioning

confidence: 99%

Thermal and hydrolytic degradation of electrospun fish gelatin membranes

et al. 2013

View full text Add to dashboard Cite

The thermal and hydrolytic degradation of electrospun gelatin membranes cross-linked with glutaraldehyde in vapor phase has been studied. In vitro degradation of gelatin membranes was evaluated in phosphate buffer saline solution at 37 ºC. After 15 days under these conditions, a weight loss of 68 % was observed, attributed to solvation and depolymerization of the main polymeric chains. Thermal degradation kinetics of the gelatin raw material and as-spun electrospun membranes showed that the electrospinning processing conditions do not influence polymer degradation. However, for cross-linked samples a decrease in the activation energy was observed, associated with the effect of glutaraldehyde cross-linking reaction in the inter-and intra-molecular hydrogen bonds of the protein. It is also shown that the electrospinning process does not affect the formation of the helical structure of gelatin chains. Polymer Testing 32 (5), 995http://dx

show abstract

Section: Resultsmentioning

confidence: 99%

Thermal and hydrolytic degradation of electrospun fish gelatin membranes

et al. 2013

View full text Add to dashboard Cite

show abstract

“…However, FDMA cannot be cross-linked using conventional cross-linking approaches such as exposing the fibers to a waterbased cross-linking solution (28). Also, the nonvolatile nature of the cross-linking agent prevents the use of the vapor-phase crosslinking method (29)(30)(31). Several studies have described various other methods of creating cross-linked fibers; such as using heat (32)(33)(34)(35)(36) or UV radiation (20,(37)(38)(39) to initiate the cross-linking reaction during or after the synthesis of the fibers.…”

Section: Resultsmentioning

confidence: 99%

Engineering of bio-hybrid materials by electrospinning polymer-microbe fibers

Liu

Rafailovich

Malal

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Although microbes have been used in industrial and niche applications for several decades, successful immobilization of microbes while maintaining their usefulness for any desired application has been elusive. Such a functionally bioactive system has distinct advantages over conventional batch and continuous-flow microbial reactor systems that are used in various biotechnological processes. This article describes the use of polyethylene oxide 99-polypropylene oxide 67-polyethylene oxide99 triblock polymer fibers, created via electrospinning, to encapsulate microbes of 3 industrially relevant genera, namely, Pseudomonas, Zymomonas, and Escherichia. The presence of bacteria inside the fibers was confirmed by fluorescence microscopy and SEM. Although the electrospinning process typically uses harsh organic solvents and extreme conditions that generally are harmful to bacteria, we describe techniques that overcome these limitations. The encapsulated microbes were viable for several months, and their metabolic activity was not affected by immobilization; thus they could be used in various applications. Furthermore, we have engineered a microbe-encapsulated cross-linked fibrous polymeric material that is insoluble. Also, the microbe-encapsulated active matrix permits efficient exchange of nutrients and metabolic products between the microorganism and the environment. The present results demonstrate the potential of the electrospinning technique for the encapsulation and immobilization of bacteria in the form of a synthetic biofilm, while retaining their metabolic activity. This study has wide-ranging implications in the engineering and use of novel bio-hybrid materials or biological thin-film catalysts.biofilm ͉ cross-linking ͉ immobilization ͉ microbial ͉ Zymomonas

show abstract

“…Nanofiber mats from different types of polymers have been investigated in vitro with fibroblast cells. The studies have been performed by using natural polymers such as collagen [18], gelatin [19] and synthetic polymers such as PLGA [20], PCL [21]. The results showed that the electrospun nanofiber mats could support the attachment and proliferation of fibroblast cells.…”

Section: Skin Regenerationmentioning

confidence: 99%

Potential Applications of Nonwoven Polymer Mats – Review

Louda

Fijalkowski

Rożek

et al. 2013

Contemporary Materials

View full text Add to dashboard Cite

Nonwoven polymer mats with fibre diameters in the nanometer and micrometer range are distinguished for their high porosity with very small pore size, interconnectivity and controllable mesh thickness. These characteristics associated to the easy way to obtain the polymer nanofibres and a large surface area to volume ratio make the nonwoven fiber mats a suitable material for different applications, such as biosensor, electronic materials and filters. Polymer nanofibers mats are being considered for use in biomedical applications, including the production of artificial blood vessels, scaffolds for engineered tissues, wound dressings.

show abstract

Crosslinking of the electrospun gelatin nanofibers

Cited by 576 publications

References 33 publications

Thermal and hydrolytic degradation of electrospun fish gelatin membranes

Thermal and hydrolytic degradation of electrospun fish gelatin membranes

Engineering of bio-hybrid materials by electrospinning polymer-microbe fibers

Potential Applications of Nonwoven Polymer Mats – Review

Contact Info

Product

Resources

About