Crosslinking of polysaccharides with activated dimethylsulfoxide

Petronijević, Živomir; Maluckov, Biljana S.; Šmelcerović, Andrija

doi:10.1016/j.tetlet.2013.04.050

Cited by 6 publications

(7 citation statements)

References 25 publications

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“…The structures containing hydrophilic outer shell enclosing the hydrophobic interior serve as carrier for hydrophobic drug molecules [146]. The modification of polysaccharides with long chain fatty acids such as palmitic acid, stearic acid, linoleic acid, linolenic acid, and hexanoic acid result in the generation of polymeric micelles [147][148]. Similarly, the conjugation of polysaccharides to hydrophobic polymers such as poly (εcaprolactone), poly (isobutyl cyanoacrylate), poly (ethylene glycol) derivatives, and pluronic copolymers generated the desired core-shell drug delivery systems with hydrophobic core and hydrophilic shell [149].…”

Section: Physical Interactionsmentioning

confidence: 99%

Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

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The polysaccharide-based advanced drug delivery system owing to their biocompatibility, ability to encapsulate the drug molecules in their interspaces, and ability to achieve a controlled release of the cargo drug molecules result in improved drug pharmacokinetics. The drug-loaded polysaccharides possess ability to evade the multidrug-resistant microbial efflux pumps by aggregation effect, whereas the drug loaded polysaccharidefabricated metal nanoparticles present an exceptional candidature for effectively transporting the drug molecules across the membrane barriers while enabling the theranostic applications at the same time. The biodegradability of polysaccharide based drug delivery systems ensure a sustained release of the encapsulated drug molecules, which minimizes the side effects caused by a burst release of the cargo therapeutics. These drug delivery systems proved highly beneficial for the NSAIDs that otherwise manifest ulcerogenic effect in the gastrointestinal tract. The large surface area of polysaccharides further provide a higher drug-loading capacity, which maintains the optimal concentration of the cargo drug at the target sites. The emerging applications of biodegradable polysaccharides in the designing of multicompartmental microspheres revolutionized tissue engineering, multi drug delivery, and cell culturing technologies. The present review deals with the current-status of polysaccharides as advanced drug delivery systems.

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Section: Physical Interactionsmentioning

confidence: 99%

Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

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“…Comparing the reactions under synthetic air or N 2 at the same temperature, the higher formation of humins in inert atmosphere is related to the high amount of 5-HMF present in the former reaction period. Yalpani (1985) and Petronijevic et al (2013) demonstrated several reactions in which DMSO shows crosslinking agent behavior with polysaccharides, when in the presence of aldehydes and organic acids. The presence of high concentrations of 5-HMF and fructose in the reaction medium must have enhanced the ability of DMSO to promote crosslinking, favoring fructose polymerization and humin formation.…”

Section: Catalytic Testsmentioning

confidence: 99%

Influence of Dimethylsulfoxide and Dioxygen in the Fructose Conversion to 5-Hydroxymethylfurfural Mediated by Glycerol's Acidic Carbon

et al. 2020

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Both the catalytic production of 5-hydroxymethylfurfural (5-HMF) from carbohydrates and the use of a catalyst obtained from residues stand out for adding value to by-products and wastes. These processes contribute to the circular economy. In this work it was evaluated optimized conditions for 5-HMF production from fructose with high yield and selectivity. The reaction was catalyzed by an acidic carbon obtained from glycerol, a byproduct of the biodiesel industry. Special attention has been given to the use of dimethyl sulfoxide (DMSO) as a solvent and its influence on system activity, both in the presence and absence of O 2. Glycerol's carbon with acidic properties can be effectively used as catalyst in fructose dehydration, allowed achieving conversions close to 100% with 5-HMF selectivities higher than 90%. The catalyst can be reused in consecutive batch runs. The influence of DMSO in the presence of O 2 should be considered in the catalytic activity, as the stabilization of a reaction intermediate by the [O 2 :DMSO] complex is favored and, both fructose conversion and 5-HMF yield increase.

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“…The crude residue was purified by crystallization from EtOAc or by short column chromatography (petroleum ether/EtOAc) as a mentioned in the text. 4 : C,76.22;H,5.45;N,3.29;Found: C,76.30;H,5.59;N,3.36. Calcd for C 26 H 20 ClNO 3 : C,72.64;H,4.69;N,3.26.…”

Section: Entrymentioning

confidence: 99%

“…Activated DMSO can be prepared by reaction of DMSO and a species of electrophile such as acetic anhydride, oxalyl chloride, dicyclohexylcarbodiimide, cyanuric chloride, and propylphosphonic anhydride which a sulfonium species containing a good‐leaving group linked to the positive sulfur atom is formed . This reagent has been used for the oxidation of alcohols , the synthesis of nitriles from aldoximes and the synthesis of cross‐linking of polysaccharides . …”

Section: Introductionmentioning

confidence: 99%

β‐Lactam Preparation via Staudinger Reaction with Activated Dimethylsulfoxide

Zarei

2016

Journal of Heterocyclic Chem

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An efficient synthesis of β‐lactams has been expediently accomplished. These β‐lactams were synthesized by the Staudinger reaction of several substituted imines with various carboxylic acids using activated DMSO at ambient temperature. The imines and substituted acetic acids contain alkyl, aryl, hetero aryl, polycyclic, and 3‐electron‐withdrawing group underwent [2 + 2] ketene‐imine cycloaddition reaction smoothly to obtain the desired β‐lactams in good to excellent yields. This method is cheap, simple, convenient, and efficient, and the products are easily isolated.

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Crosslinking of polysaccharides with activated dimethylsulfoxide

Cited by 6 publications

References 25 publications

Current-status and applications of polysaccharides in drug delivery systems

Current-status and applications of polysaccharides in drug delivery systems

Influence of Dimethylsulfoxide and Dioxygen in the Fructose Conversion to 5-Hydroxymethylfurfural Mediated by Glycerol's Acidic Carbon

β‐Lactam Preparation via Staudinger Reaction with Activated Dimethylsulfoxide

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