Crosslinked α,β-polyasparthydrazide hydrogels: effect of crosslinking degree and loading method on cytarabine release rate

Giammona, Gaetano; Pitarresi, Giovanna; Tomarchio, Vincenzo; Cavallaro, Gennara; Mineo, Massimo

doi:10.1016/0168-3659(96)01322-3

Cited by 24 publications

(7 citation statements)

References 17 publications

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“…2 Recently, hydrogels have been extensively studied as drug carriers, especially for proteins. Hydrogels have been made from different polymers such as dextran, 3 gelatin, 4-6 amylose, 7-9 cellulose, 10 chitosan, 11 fibrin, 12 collagen, 13,14 alginate, 15,16 poly(vinyl alcohol), 17 poly(hydroxyethyl methacrylate), 18,19 poly(hydroxyethyl acrylate), 20 poly(acrylic acid) (Carbopol), 21 polyasparthydrazide, 22 and poly(ethylene glycol) (PEG). 23,24 Most hydrogel-based drug delivery systems are designed as implants that release drug locally at a predetermined rate.…”

Section: Introductionmentioning

confidence: 99%

Novel Degradable Poly(Ethylene Glycol) Hydrogels for Controlled Release of Protein

Zhao

Harris

1998

Journal of Pharmaceutical Sciences

116

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Hydrogels have become increasingly important in the biomedical field. This paper describes synthesis and characterization of two types of novel degradable poly(ethylene glycol) (PEG) hydrogels with potential utility as delivery carriers for bioactive drugs. The simplest gel is prepared by one-step polycondensation of difunctional PEG acid and branched PEG "polyol". The second type of the novel degradable PEG hydrogel was prepared in a two-step process, in which an ester-containing, amine-reactive PEG derivative was synthesized and then reacted with a branched PEG amine to form the gel. The two-step gels are formed in very mild conditions, and therefore fragile drugs such as proteins can be loaded during gel formation. Because most proteins have free amino groups in the sequence, these proteins can be covalently linked to the hydrogel network. This covalent attachment provides a new way to achieve long-term controlled release of proteins. These hydrogels have a wide range of degradation rates. Upon hydrolysis, these PEG hydrogels will degrade into low molecular weight PEG derivatives, which can be easily cleared by the body.

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Section: Introductionmentioning

confidence: 99%

Novel Degradable Poly(Ethylene Glycol) Hydrogels for Controlled Release of Protein

Zhao

Harris

1998

Journal of Pharmaceutical Sciences

116

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“…The drug release rate is strongly dependent on the characteristics of the gel structure, which, in some cases, can be easily modified [1][2][3]. Under this respect matrices based on κ-carrageenan deserve great interest.…”

Section: Introductionmentioning

confidence: 99%

Relation between structural and release properties in a polysaccharide gel system

Mangione

Giacomazza

Cavallaro

et al. 2007

Biophysical Chemistry

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The potential utility of κ-carrageenan gels for preparing drug release devices is here shown. Structural properties of κ-carrageenan gels prepared with different salt composition and containing Ketoprofen sodium salt, as model drug, have been evaluated with static light scattering and rheological measurements. These properties have been correlated with release profiles in vitro at pH 5.5. Release properties from gelled matrices have been compared with those obtained by two commercial products containing the same drug. Results show that: i) in this system it is possible to easily control the gel texture by using different cationic concentration; ii) the kinetics of drug release by κ-carrageenan gels are dependent on the structural properties of matrices; iii) in the typical interval time used in classical local applications, all gel samples release the loaded drug almost completely, at difference with the commercial products. All these findings can provide useful suggestions for the realization of classical topical release systems.

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“…The literatures on preparation and uses of water-insoluble polyaspartyl polymers have been reported, but they were mostly centered on waterabsorbing materials or drug-loading carriers. [4][5][6][7][8] Moreover, organic solvents, such as DMF, DMSO, and so on, were used in the preparation processes. Such a process is harmful to human being and expensive in cost, and the recovery of these solvents releases many wastewater, which brings up grave environmental concerns.…”

Section: Introductionmentioning

confidence: 99%

“…But it is still necessary to extend their applications, especially as water‐insoluble polyaspartyl polymers. The literatures on preparation and uses of water‐insoluble polyaspartyl polymers have been reported, but they were mostly centered on water‐absorbing materials or drug‐loading carriers 4–8. Moreover, organic solvents, such as DMF, DMSO, and so on, were used in the preparation processes.…”

Section: Introductionmentioning

confidence: 99%

Binding of several heavy metal ions by polyaspartyl polymers and their application to some Chinese herbal medicines

Sun

et al. 2007

J of Applied Polymer Sci

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Water-insoluble polyaspartyl polymers were synthesized by using water as medium instead of organic medium. Taking , and Mn 2þ , by polyaspartyl polymers was studied. The experimental results revealed that polyaspartate is an excellent binding agent for the investigated heavy-metal ions. These cation ions were bound to polyaspartate polymer by the same mechanism as Pb 2þ , which can be explained by ion exchange model. Since polyaspartate has a protein-resembling structure that is sensitive to trace heavy metal, it was used to remove some trace heavy-metal elements in Chinese herbal medicines. It was found that polyaspartate material was an effective agent for the removal of Pb 2þ , Cd 2þ , and Hg 2þ ions from glycyrrhizin, angelica, and gynostemma pentaphyllum.

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Crosslinked α,β-polyasparthydrazide hydrogels: effect of crosslinking degree and loading method on cytarabine release rate

Cited by 24 publications

References 17 publications

Novel Degradable Poly(Ethylene Glycol) Hydrogels for Controlled Release of Protein

Novel Degradable Poly(Ethylene Glycol) Hydrogels for Controlled Release of Protein

Relation between structural and release properties in a polysaccharide gel system

Binding of several heavy metal ions by polyaspartyl polymers and their application to some Chinese herbal medicines

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