Crosslinked thiolated starch coated Fe₃O₄magnetic nanoparticles: Effect of montmorillonite and crosslinking density on drug delivery properties

Abstract

The anti‐tuberculosis drug isoniazid was incorporated within crosslinked thiolated starch coated magnetic iron oxide nanoparticles, aiming to reach a controlled drug delivery system. The coated magnetic nanoparticles were characterized by FTIR, XRD study, and Vibrating Sample Magnetometer (VSM). The morphology and dimensional characteristics of the nanoparticles were analyzed by SEM, TEM, and Dynamic Light Scattering (DLS) method. The drug release mechanism was studied at pH 1.2 and pH 7.4 for different time periods by UV–visible spectrophotometer. Cytotoxicity study was performed by MTT assay analysis. Mucoadhesivity study was done by in vitro wash‐off and ex vivo mucoadhesive test. The incorporation of montmorillonite and crosslinking of the nanoparticles were found to improve the cell viability, mucoadhesivity, and drug release properties. The properties of the prepared nanoparticles suggested their prospects for biomedical applications.

A study of films based on starch and Na‐montmorillonite designed for prolonged release of oxytetracycline hydrochloride

“…Similar results showing that the starch matrix SD becomes higher as the MMT concentration increases in the nanocomposites have been also obtained by the authors of work. [ 36 ] On the one hand, the effect of the SD reduction as a result of MMT/OTC particle inclusion into the starch film is undesirable in terms of sustaining the OTC release from the film, since this lowers the diffusion path of the OTC molecules and, therefore, must increase the release rate of the latter. On the other hand, the effect of the decrease in the transport rate of low‐molecular substances (the OTC molecules are among them) in the St/MMT/OTC film structure, is positive for the prolongation of the OTC release from the starch matrix.…”

Formulation and Evaluation of Ethambutol Polymeric Nanoparticles

“…The amount of free drug was analyzed by a UV-Visible spectrophotometer at a wavelength of 267 nm. The drug entrapment efficiency (EE) and drug loading (DL) was calculated using the following equation [28]:…”

Sodium alginate–polyvinyl alcohol–bovin serum albumin coated Fe3O4 nanoparticles as anticancer drug delivery vehicle: Doxorubicin loading and in vitro release study and cytotoxicity to HepG2 and L02 cells

“…A calibration curve is essential to evaluate the release rate of drug from nanoparticles in an appropriate medium [54]. A known concentration of (5-25 mg/mL) DOX was scanned by …”