Crosslinked self-assembled nanoparticles for chemo-sonodynamic combination therapy favoring antitumor, antimetastasis management and immune responses

Liu, Mengrui; Khan, Abdur Rauf; Ji, Jianbo; Lin, Guimei; Zhao, Xiaogang; Zhai, Guangxi

doi:10.1016/j.jconrel.2018.10.007

Cited by 111 publications

(74 citation statements)

References 72 publications

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“…Similarly, based on the use of chondroitin sulfate (CS) modified with hydrophobic segments to form self‐assembled NPs, Liu et al. developed a multiresponsive chondroitin sulfate‐Ce6‐lipoic acid nanoplatform (CS‐ADH‐Ce6‐LA) loaded with docetaxel for chemo‐sonodynamic therapy (Figure C) . Furthermore, Wang et al.…”

Section: Organic Sonosensitizersmentioning

confidence: 99%

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Ultrasound‐Activated Sensitizers and Applications

et al. 2020

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Modalities for photo‐triggered anticancer therapy are usually limited by their low penetrative depth. Sonotheranostics especially sonodynamic therapy (SDT), which is different from photodynamic therapy (PDT) by the use of highly penetrating acoustic waves to activate a class of sound‐responsive materials called sonosensitizers, has gained significant interest in recent years. The effect of SDT is closely related to the structural and physicochemical properties of the sonosensitizers, which has led to the development of new sound‐activated materials as sonosensitizers for various biomedical applications. This Review provides a summary and discussion of the types of novel sonosensitizers developed in the last few years and outlines their specific designs and the potential challenges. The applications of sonosensitizers with various functions such as for imaging and drug delivery as well as in combination with other treatment modalities would provide new strategies for disease therapy.

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Section: Organic Sonosensitizersmentioning

confidence: 99%

Section: Organic Sonosensitizersmentioning

confidence: 99%

Ultrasound‐Activated Sensitizers and Applications

et al. 2020

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“…16,17 Specifically, in the cases of skin tumors, SDT has shown to be more efficacious to treat deeper seated or highly pigmented tumors such as malignant melanoma than photodynamic therapy. 14,15,18 LFU is, however, rarely used in SDT, with highfrequency ultrasound being the most studied, although less energetic. It is known that the tissue penetration depth of the LFU is greater than that of the highfrequency ultrasound.…”

Section: Introductionmentioning

confidence: 99%

<p>Bifunctional Therapeutic Application of Low-Frequency Ultrasound Associated with Zinc Phthalocyanine-Loaded Micelles</p>

Martins¹,

Fonseca²,

Pavan³

et al. 2020

IJN

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Purpose: Sonodynamic therapy (SDT) is a new therapeutic modality for the noninvasive cancer treatment based on the association of ultrasound and sonosensitizer drugs. Topical SDT requires the development of delivery systems to properly transport the sonosensitizer, such as zinc phthalocyanine (ZnPc), to the skin. In addition, the delivery system itself can participate in sonodynamic events and influence the therapeutic response. This study aimed to develop ZnPc-loaded micelle to evaluate its potential as a topical delivery system and as a cavitational agent for low-frequency ultrasound (LFU) application with the dual purpose of promoting ZnPc skin penetration and generating reactive oxygen species (ROS) for SDT. Methods: ZnPc-loaded micelles were developed by the thin-film hydration method and optimized using the Quality by Design approach. Micelles' influence on LFU-induced cavitation activity was measured by potassium iodide dosimeter and aluminum foil pits experiments. In vitro skin penetration of ZnPc was assessed after pretreatment of the skin with LFU and simultaneous LFU treatment using ZnPc-loaded micelles as coupling media followed by 6 h of passive permeation of ZnPc-loaded micelles. The singlet oxygen generation by LFU irradiation of the micelles was evaluated using two different hydrophilic probes. The lipid peroxidation of the skin was estimated using the malondialdehyde assay after skin treatment with simultaneous LFU using ZnPc-loaded micelles. The viability of the B16F10 melanoma cell line was evaluated using resazurin after treatment with different concentrations of ZnPc-loaded micelles irradiated or not with LFU. Results: The micelles increased the solubility of ZnPc and augmented the LFU-induced cavitation activity in two times compared to water. After 6 h ZnPc-loaded micelles skin permeation, simultaneous LFU treatment increased the amount of ZnPc in the dermis by more than 40 times, when compared to non-LFU-mediated treatment, and by almost 5 times, when compared to LFU pretreatment protocol. The LFU irradiation of micelles induced the generation of singlet oxygen, and the lipoperoxidation of the skin treated with the simultaneous LFU was enhanced in three times in comparison to the non-LFU-treated skin. A significant reduction in cell viability following treatment with ZnPc-loaded micelles and LFU was observed compared to blank micelles and non-LFU-treated control groups. Conclusion: LFU-irradiated mice can be a potential approach to skin cancer treatment by combining the functions of increasing drug penetration and ROS generation required for SDT.

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“…Auf ähnliche Weise entwickelten Liu et al. basierend auf Chondroitinsulfat (CS), das mit hydrophoben Segmenten modifiziert werden kann, um selbstorganisierte NPs zu bilden, eine multi‐responsive Chondroitinsulfat‐Ce6‐Liponsäure‐Nanoplattform CS‐ADH‐Ce6‐LA beladen mit Docetaxel für die chemosonodynamische Therapie (Abbildung C) . Nicht nur das, Wang et al.…”

Section: Organische Sonosensibilisatorenunclassified

Ultraschallaktivierte Sensibilisatoren

et al. 2020

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Durch Licht ausgelöste Verfahren in der Krebstherapie sind üblicherweise durch ihre geringe Penetrationstiefe limitiert. Die Sonotheranostika, insbesondere die sonodynamische Therapie (SDT), die sich von der photodynamischen Therapie (PDT) unterscheidet und hoch penetrierende Schallwellen zur Aktivierung einer Klasse von schallresponsiven Materialien verwendet, die als Sonosensibilisatoren bezeichnet werden, hat in den letzten Jahren an erheblichem Interesse gewonnen. Der Effekt der SDT hängt eng mit den strukturellen und physikochemischen Eigenschaften der Sonosensibilisatoren zusammen, was die Entwicklung von neuen schallaktivierbaren Materialien als Sonosensibilisatoren für diverse biomedizinische Anwendungen erforderlich gemacht hat. Dieser Aufsatz enthält eine Zusammenfassung und Diskussion der neuartigen Typen von Sonosensibilisatoren, die in den letzten Jahren entwickelt wurden. Anwendungen von Sonosensibilisatoren mit vielfältigen Funktionen wie Bildgebung, Wirkstofftransport und die Kombination mit anderen Behandlungsmethoden sollten neue Strategien für die Krankheitstherapie zur Verfügung stellen.

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Crosslinked self-assembled nanoparticles for chemo-sonodynamic combination therapy favoring antitumor, antimetastasis management and immune responses

Cited by 111 publications

References 72 publications

Ultrasound‐Activated Sensitizers and Applications

Ultrasound‐Activated Sensitizers and Applications

<p>Bifunctional Therapeutic Application of Low-Frequency Ultrasound Associated with Zinc Phthalocyanine-Loaded Micelles</p>

Ultraschallaktivierte Sensibilisatoren

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