Crosslinked poly(vinyl alcohol) hydrogels as swollen elastic networks

Peppas, Nikolaos A.; Merrill, Edward W.

doi:10.1002/app.1977.070210704

Cited by 351 publications

(264 citation statements)

References 13 publications

(2 reference statements)

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“…The values of E ranged from 63 to 126 kPa. Peppas and Merrill [37] obtained wider range for E values (31 to 340 kPa) using PVA hydrogels crosslinked by electron beam irradiating 10 wt% polymer aqueous solution. These authors observed that for those polymers the value of E depends on the radiation dose due to its effect in the degree of cross-linking.…”

Section: Hydrogel Mechanical Propertiesmentioning

confidence: 97%

Hydrogels based on chemically modified poly(vinyl alcohol) (PVA-GMA) and PVA-GMA/chondroitin sulfate: Preparation and characterization

Crispim¹,

Piai²,

Fajardo³

et al. 2012

Express Polym. Lett.

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This work reports the preparation of hydrogels based on PVA-GMA, PVA-GMA is poly(vinyl alcohol) (PVA) functionalized with vinyl groups from glycidyl methacrylate (GMA), and on PVA-GMA with different content of chondroitin sulfate (CS). The degrees of swelling of PVA-GMA and PVA-GMA/CS hydrogels were evaluated in distilled water and the swelling kinetics was performed in simulated gastric and intestinal fluids (SGF and SIF). PVA-GMA and PVAGMA/CS hydrogels demonstrated to be resistant on SGF and SIF fluids. The elastic modulus, E, of swollen-hydrogels were determined through compressive tests and, according to the obtained results, the hydrogels presented good mechanical properties. At last, the presence of CS enhances the hydrogel cell compatibility as gathered by cytotoxicity assays. It was concluded that the hydrogels prepared through this work presented characteristics that allow them to be used as biomaterial, as a carrier in drug delivery system or to act as scaffolds in tissue engineering as well

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Section: Hydrogel Mechanical Propertiesmentioning

confidence: 97%

Hydrogels based on chemically modified poly(vinyl alcohol) (PVA-GMA) and PVA-GMA/chondroitin sulfate: Preparation and characterization

Crispim¹,

Piai²,

Fajardo³

et al. 2012

Express Polym. Lett.

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“…to a clay-crosslinked PVOH hydrogel in which the network active PVOH chains only experience a minimum number of significant interactions with the clay mineral surface. 24 The adsorption isotherm for PVOH was described by L-class, subgroup 3 due to the increasing amounts of PVOH adsorbed beyond the knee of the isotherm and the further increase at higher concentrations. 19,20 Bussetti and Ferreiro 25 described the adsorption of PVOH (MW= 14,000) on Na-montmorillonite at 28 °C as an H-class, subgroup 2 isotherm and calculated the adsorption maximum to be 0.496 g PVOH/g clay, which is close to the value at which free PVOH is observed here (between 0.33 g PVOH/g NaMt).…”

Section: Individual Adsorption Isotherm -Pegmentioning

confidence: 99%

“…The x-ray diffraction analysis of the cast films prepared from binary mixtures of PVOH and PEG focused on the samples in Figure 2; particularly the addition of 10 and 30 pph PEG 24 which provided a stable monolayer and bilayer, respectively (Figure 5a). The XRD patterns in Figure 7 illustrate how each incremental addition of PEG to samples of PVOH-NaMt moved the d 001 peak to smaller angles (higher spacing).…”

Section: X-ray Diffraction Analysis Of Pvoh-peg-namt Samplesmentioning

confidence: 99%

Synergistic and Competitive Aspects of the Adsorption of Poly(ethylene glycol) and Poly(vinyl alcohol) onto Na-Bentonite

2014

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The competitive adsorption of poly(ethylene glycol) (PEG) and poly(vinyl alcohol) (PVOH) onto Na-bentonite has been assessed quantitatively. Particular emphasis was focused on the amount of organic located within the bentonite interlayer and any subsequent effects on the extent of layer expansion. The individual isotherms showed strong adsorption for both PVOH and PEG at amounts lower than the quantities required to produce fully loaded bilayer (0.33 g of PVOH/g of clay) and single layered structures (0.10 g of PEG/g of clay), respectively. Above these concentrations the incremental amounts adsorbed were smaller, and the concentration of adsorbates in solution gradually increased. Na-bentonite adsorbed more PVOH than PEG at any given concentration. In the competitive study the amount of PVOH adsorbed was enhanced in the presence of PEG (0.10 and 0.30 g/g clay), but less PEG was adsorbed. At low loadings of PVOH (0.02-0.10 g/g clay) the amount of adsorbed PEG was increased but at higher PVOH levels PEG adsorption was reduced. The XRD data showed stepped changes in the d-spacing as the adsorbed amounts of both PEG and PVOH increased. The PEG-bentonite samples did not expand beyond a bilayer structure (18 Å), but the XRD data for PVOH-treated samples indicated the formation of multilayer structures (d ≥ 44 Å).

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“…In addition to covalent crosslinking, hydrogels can be rendered insoluble by virtual crosslinks formed by charged main chain and/or pendant groups that are capable of electrostatic bonding to themselves and to imbibed free ions [18]. Swelling of hydrogels, driven by thermodynamics, is governed by the solvating forces involved with polymer-solvent mixing, the relaxation forces involved with the elasticity of the crosslinks, and the osmotic pressure introduced by ionic forces [19,20]. The extent of hydrogel swelling in a salt solution will depend on external and internal ion concentration, which influences the balance between the solvating and retractive forces.…”

Section: Introductionmentioning

confidence: 99%

Release of Potassium Ion and Calcium Ion from Phosphorylcholine Group Bearing Hydrogels

et al. 2013

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Abstract:In an attempt to recreate the microenvironment necessary for directed hematopoietic stem cell differentiation, control over the amount of ions available to the cells is necessary. The release of potassium ion and calcium ion via the control of cross-linking density of a poly(2-hydroxyethyl methacrylate) (pHEMA)-based hydrogel containing 1 mol % 2-methacryloyloxyethyl phosphorylcholine (MPC) and 5 mol % oligo(ethylene glycol) (400) monomethacrylate [OEG(400)MA] was investigated. Tetra(ethylene glycol) diacrylate (TEGDA), the cross-linker, was varied over the range of 1-12 mol %. Hydrogel discs (ϕ = 4.5 mm and h = 2.0 mm) were formed by UV polymerization within silicone isolators to contain 1.0 M CaCl 2 and 0.1 M KCl, respectively. Isothermal release profiles, were measured at 37 °C in 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid sodium salt (HEPES) buffer using either calcium ion or potassium ion selective electrodes (ISE). The resulting release OPEN ACCESSPolymers 2013, 5 1242 profiles were found to be independent of cross-linking density. Average (n = 3) release profiles were fit to five different release models with the Korsmeyer-Peppas equation, a porous media transport model, exhibiting the greatest correlation (R 2 > 0.95). The diffusion exponent, n was calculated to be 0.24 ± 0.02 and 0.36 ± 0.04 for calcium ion and potassium ion respectively indicating non-Fickian diffusion. The resulting diffusion coefficients were calculated to be 2.6 × 10 −6 and 11.2 × 10 −6 cm 2 /s, which compare well to literature values of 2.25 × 10 −6 and 19.2 × 10 −6 cm 2 /s for calcium ion and potassium ion, respectively.

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Crosslinked poly(vinyl alcohol) hydrogels as swollen elastic networks

Cited by 351 publications

References 13 publications

Hydrogels based on chemically modified poly(vinyl alcohol) (PVA-GMA) and PVA-GMA/chondroitin sulfate: Preparation and characterization

Hydrogels based on chemically modified poly(vinyl alcohol) (PVA-GMA) and PVA-GMA/chondroitin sulfate: Preparation and characterization

Synergistic and Competitive Aspects of the Adsorption of Poly(ethylene glycol) and Poly(vinyl alcohol) onto Na-Bentonite

Release of Potassium Ion and Calcium Ion from Phosphorylcholine Group Bearing Hydrogels

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