Crosslinked Hyaluronan Electrospun Nanofibers for Ferulic Acid Ocular Delivery

Grimaudo, Maria Aurora; Concheiro, Angel

doi:10.3390/pharmaceutics12030274

Cited by 55 publications

(27 citation statements)

References 53 publications

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“…The results showed acceptable thickness of 270 ± 21 μm to 273 ± 41 μm with fiber diameter of approx. 100 nm to 1 μm; in addition, they demonstrated adequate drug release, with antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Drug-Loaded Electrospun Nanofiber-Based Ophthalmic Inserts

Omer

Zelkó

2021

Pharmaceutics

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Currently, ocular inserts and nanoparticles have received much attention due to the limited bioavailability of conventional eye preparations and the toxicity problems of systemic drug administration. The current systematic review aims to present recent studies on the use of electrospun nanofiber-based ocular inserts to improve the bioavailability of drugs used for different ophthalmic diseases. A systematic search was performed in PubMed, Ovid Medline, Web of Science, ScienceDirect, Scopus, Reaxys, Google Scholar, and Google Patents/Espacenet taking “drug-loaded”, “nanofibers”, and “ophthalmic inserts” and their equivalent terms as keywords. The search was limited to original and peer-reviewed studies published in 2011–2021 in English language. Only 13 out of 795 articles and 15 out of 197 patents were included. All results revealed the success of nanofiber-based ocular inserts in targeting and improved bioavailability. Ocular inserts based on nanofibers can be used as safe, efficient carriers for the treatment of anterior and posterior eye diseases.

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Section: Resultsmentioning

confidence: 99%

A Systematic Review of Drug-Loaded Electrospun Nanofiber-Based Ophthalmic Inserts

Omer

Zelkó

2021

Pharmaceutics

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“…Upon application to the ocular surface, the fibrous lens hydrates to form a film/hydrogel. A different study utilized electrospun PVP and HA nanofibers to develop hydrogels for drug delivery (185). This study focused on developing an ocular insert to deliver ferulic acid and Epsiliseen R -H for treating ocular surface conditions.…”

Section: Fibers Films Rods Extrusionsmentioning

confidence: 99%

Considerations for Polymers Used in Ocular Drug Delivery

et al. 2022

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PurposeAge-related eye diseases are becoming more prevalent. A notable increase has been seen in the most common causes including glaucoma, age-related macular degeneration (AMD), and cataract. Current clinical treatments vary from tissue replacement with polymers to topical eye drops and intravitreal injections. Research and development efforts have increased using polymers for sustained release to the eye to overcome treatment challenges, showing promise in improving drug release and delivery, patient experience, and treatment compliance. Polymers provide unique properties that allow for specific engineered devices to provide improved treatment options. Recent work has shown the utilization of synthetic and biopolymer derived biomaterials in various forms, with this review containing a focus on polymers Food and Drug Administration (FDA) approved for ocular use.MethodsThis provides an overview of some prevalent synthetic polymers and biopolymers used in ocular delivery and their benefits, brief discussion of the various types and synthesis methods used, and administration techniques. Polymers approved by the FDA for different applications in the eye are listed and compared to new polymers being explored in the literature. This article summarizes research findings using polymers for ocular drug delivery from various stages: laboratory, preclinical studies, clinical trials, and currently approved. This review also focuses on some of the challenges to bringing these new innovations to the clinic, including limited selection of approved polymers.ResultsPolymers help improve drug delivery by increasing solubility, controlling pharmacokinetics, and extending release. Several polymer classes including synthetic, biopolymer, and combinations were discussed along with the benefits and challenges of each class. The ways both polymer synthesis and processing techniques can influence drug release in the eye were discussed.ConclusionThe use of biomaterials, specifically polymers, is a well-studied field for drug delivery, and polymers have been used as implants in the eye for over 75 years. Promising new ocular drug delivery systems are emerging using polymers an innovative option for treating ocular diseases because of their tunable properties. This review touches on important considerations and challenges of using polymers for sustained ocular drug delivery with the goal translating research to the clinic.

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“…Similarly, Zhang and Shen [ 50 ] demonstrated the amelioration of the hemocompatibility and reduced platelet adhesion of a potential coating film based on poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) for stent application. Finally, several other studies demonstrated anti-inflammatory, anti-arrhythmic, anti-cancer activities, hepato-, and eyes-protective properties [ 51 , 52 , 53 , 54 , 55 ].…”

Section: Hydroxycinnamic Acids and Derivatives: General Uses And Current Applicationsmentioning

confidence: 99%

Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

et al. 2021

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Alterations of skin homeostasis are widely diffused in our everyday life both due to accidental injuries, such as wounds and burns, and physiological conditions, such as late-stage diabetes, dermatitis, or psoriasis. These events are locally characterized by an intense inflammatory response, a high generation of harmful free radicals, or an impairment in the immune response regulation, which can profoundly change the skin tissue’ repair process, vulnerability, and functionality. Moreover, diabetes diffusion, antibiotic resistance, and abuse of aggressive soaps and disinfectants following the COVID-19 emergency could be causes for the future spreading of skin disorders. In the last years, hydroxycinnamic acids and derivatives have been investigated and applied in several research fields for their anti-oxidant, anti-inflammatory, and anti-bacterial activities. First, in this study, we give an overview of these natural molecules’ current source and applications. Afterwards, we review their potential role as valid alternatives to the current therapies, supporting the management and rebalancing of skin disorders and diseases at different levels. Also, we will introduce the recent advances in the design of biomaterials loaded with these phenolic compounds, specifically suitable for skin disorders treatments. Lastly, we will suggest future perspectives for introducing hydroxycinnamic acids and derivatives in treating skin disorders.

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Crosslinked Hyaluronan Electrospun Nanofibers for Ferulic Acid Ocular Delivery

Cited by 55 publications

References 53 publications

A Systematic Review of Drug-Loaded Electrospun Nanofiber-Based Ophthalmic Inserts

A Systematic Review of Drug-Loaded Electrospun Nanofiber-Based Ophthalmic Inserts

Considerations for Polymers Used in Ocular Drug Delivery

Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

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