Crossing biological barriers with nanogels to improve drug delivery performance

Cuggino, Julio César; Osorio‐Blanco, Ernesto Rafael; Gugliotta, Luis Marcelino; Igarzabal, Cecilia Inés Álvarez; Calderón, Marcelo

doi:10.1016/j.jconrel.2019.06.005

Cited by 128 publications

(80 citation statements)

References 115 publications

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“…A gel is a material that has a three-dimensional spatial polymerization capability and is capable of accommodating a large amount of water in its slightly crosslinked network structure. Gels have many adjustable properties, including their flexibility and deformability, dispersibility in biological fluids, controlled stability, biodegradability, and chemical function [159,160]. Compared with nanoparticles, gels have better mucoadhesivity and permeability and can transport small molecules, all of which gives them great potential in biomedical fields [161].…”

Section: Delivery Carriermentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

523

282

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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Section: Delivery Carriermentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

523

282

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“…[23] Furthermore, researchers have used miscellaneous methods and procedures to improve the performance of drugs including fabrication of nano-carriers, molecularly imprinted polymers, microchip technology, microneedle patches, ultrasound-guided delivery, stimuli-responsive delivery systems, and electroactive materials. [24][25][26][27][28][29][30][31][32] Generally, polymer materials can boost physicochemical characteristics of biomedical devices. [33,34] For example, in a recent study, surface modification by employing polymeric nanoparticles positively affected the cellular uptake of PTX NCs.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Carboxymethyl Chitosan Nanoparticles to Deliver Paclitaxel for Melanoma Treatment

et al. 2020

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In the present study, the effectiveness of paclitaxel nanocrystals (PTX NCs) encapsulated in carboxymethyl chitosan (CMCS) nanoparticles (CMCS−PTX NPs) as an anticancer drug is evaluated. The CMCS nanoparticles are produced via a cross‐junction microfluidic device where the PTX/CMCS concentration and flow rates in the device are optimized. The dynamic light scattering data show that the PTX NCs have a median diameter size of 230±90 nm, while the size of CMCS−PTX NPs is roughly 270±30 nm. The zeta‐potential result indicates less negative surface charge for the CMCS−PTX NPs as compared to the PTX NCs. Moreover, scanning electron microscopy micrographs, differential scanning calorimetry thermograms, and X‐ray diffraction patterns reveal that the physicochemical properties of the drug remain unaltered after perfusion through the microfluidic device. Cytotoxicity and cell endocytosis of PTX NCs and CMCS−PTX NPs are evaluated in vitro using G361 melanoma‐positive skin cells. The results reveal that the CMCS−PTX NPs increase the cellular uptake and cytotoxicity compared to the PTX NCs alone. In addition, the antitumor effect of CMCS−PTX NPs on B16 melanoma indicates the great potential of CMCS as a promising nano‐carrier for PTX NCs drug with potent inhibitory effect on the tumor growth.

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“…The nanotechnology field offers a great deal of drug delivery modalities in order to overpass the biological barriers, deliver efficiently the incorporated active principle in a controlled and targeted manner, reduce circulating drug levels and attenuate the renal damage. A recent review points out the nanogels based on the above-mentioned materials capabilities as an adequate example to pass through these types of biological barriers [94]. For example, the synthesized nano-drug delivery micelles based on chitosan-g-oligo (NiPAam) copolymers stabilised by ionotropic crosslinking by Raskin et al [95], gave good results for delivering antiretroviral drugs (EFV) through mucosa.…”

Section: Mucusmentioning

confidence: 99%

Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers

et al. 2020

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Viral infections are a major global health problem, representing a significant cause of mortality with an unfavorable continuously amplified socio-economic impact. The increased drug resistance and constant viral replication have been the trigger for important studies regarding the use of nanotechnology in antiviral therapies. Nanomaterials offer unique physico-chemical properties that have linked benefits for drug delivery as ideal tools for viral treatment. Currently, different types of nanomaterials namely nanoparticles, liposomes, nanospheres, nanogels, nanosuspensions and nanoemulsions were studied either in vitro or in vivo for drug delivery of antiviral agents with prospects to be translated in clinical practice. This review highlights the drug delivery nanosystems incorporating the major antiviral classes and their transport across specific barriers at cellular and intracellular level. Important reflections on nanomedicines currently approved or undergoing investigations for the treatment of viral infections are also discussed. Finally, the authors present an overview on the requirements for the design of antiviral nanotherapeutics.

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Crossing biological barriers with nanogels to improve drug delivery performance

Cited by 128 publications

References 115 publications

Chitosan Derivatives and Their Application in Biomedicine

Chitosan Derivatives and Their Application in Biomedicine

Fabrication of Carboxymethyl Chitosan Nanoparticles to Deliver Paclitaxel for Melanoma Treatment

Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers

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