Cross validation of pooling/resampling GWAS using the WTCCC data

Abstract

Recently, we presented a new method of pooling/resampling genome-wide association study (prGWAS) that uncovered new and known loci associated to Alzheimer's disease. In here, we contrast this method with the Welcome Trust Case Control Consortium (WTCCC) data, a well-known GWAS on seven human complex diseases. Our results suggest that prGWAS can be considered an efficient, specific, and accurate alternative to the conventional GWAS approach at a fraction of the genotyping cost, and provide insights into other potential applications such as next generation sequencing.