Cross‐tolerance in amphibians: Wood frog mortality when exposed to three insecticides with a common mode of action

Hua, Jessica; Cothran, Rickey D.; Stoler, Aaron B.; Relyea, Rick A.

doi:10.1002/etc.2121

Cited by 34 publications

(48 citation statements)

References 30 publications

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“…For example, Bridges and Semlitsch (2000) demonstrated that populations of leopard frogs (Lithobates sphenocephalus) vary in their tolerance to the insecticide carbaryl. Similarly, Cothran et al (2013) and Hua et al (2013a) found that populations of wood frogs (Lithobates sylvaticus) vary substantially in their tolerance to the insecticides chlorpyrifos, carbaryl, and malathion. Further, consistent with predictions of evolved tolerance, Bendis and Relyea (2014) and Cothran et al (2013) demonstrated that populations of waterfleas (Daphnia pulex) and wood frogs living farther from agriculture were less tolerant to a single, commonly applied insecticide (i.e.…”

Section: Introductionmentioning

confidence: 96%

Evolved pesticide tolerance in amphibians: Predicting mechanisms based on pesticide novelty and mode of action

Hua

Jones

Mattes

et al. 2015

Environmental Pollution

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We examined 10 wood frog populations distributed along an agricultural gradient for their tolerance to six pesticides (carbaryl, malathion, cypermethrin, permethrin, imidacloprid, and thiamethoxam) that differed in date of first registration (pesticide novelty) and mode-of-action (MOA). Our goals were to assess whether: 1) tolerance was correlated with distance to agriculture for each pesticide, 2) pesticide novelty predicted the likelihood of evolved tolerance, and 3) populations display cross-tolerance between pesticides that share and differ in MOA. Wood frog populations located close to agriculture were more tolerant to carbaryl and malathion than populations far from agriculture. Moreover, the strength of the relationship between distance to agriculture and tolerance was stronger for older pesticides compared to newer pesticides. Finally, we found evidence for cross-tolerance between carbaryl and malathion (two pesticides that share MOA). This study provides one of the most comprehensive approaches for understanding patterns of evolved tolerance in non-pest species.

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Section: Introductionmentioning

confidence: 96%

Evolved pesticide tolerance in amphibians: Predicting mechanisms based on pesticide novelty and mode of action

Hua

Jones

Mattes

et al. 2015

Environmental Pollution

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“…Over the last several years, we have used wood frogs ( Lithobates sylvaticus ) to explore patterns in pesticide tolerance (Hua, Cothran, Stoler, & Relyea, 2013; Hua, Jones, & Relyea, 2014; Hua et al., 2015). Wood frog populations inhabit pond ecosystems that can encounter pesticides following direct application, runoff, or aerial drift (Smalling et al., 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Wood frog populations inhabit pond ecosystems that can encounter pesticides following direct application, runoff, or aerial drift (Smalling et al., 2015). Using 15 populations in northwestern Pennsylvania (Hua et al., 2013, 2014, 2015), we found that populations living close to agriculture have higher baseline tolerance to a common acetylcholineesterase (AChE) inhibiting pesticide (carbaryl) compared to populations living far from agriculture (Hua et al., 2015). Using the same populations, we also investigated patterns of plasticity to carbaryl and found that the degree of plasticity to carbaryl varied along an agricultural gradient; populations close to agriculture possess high baseline but no inducible tolerance to carbaryl (i.e., constitutive tolerance), whereas populations far from agriculture possess low baseline but high inducible tolerance to carbaryl (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…Using the same populations, we also investigated patterns of plasticity to carbaryl and found that the degree of plasticity to carbaryl varied along an agricultural gradient; populations close to agriculture possess high baseline but no inducible tolerance to carbaryl (i.e., constitutive tolerance), whereas populations far from agriculture possess low baseline but high inducible tolerance to carbaryl (Figure 1). Additionally, we have demonstrated that these landscape patterns were generalizable; wood frog populations with constitutive and inducible tolerance to carbaryl also had constitutive and inducible cross‐tolerance to other AChE inhibitors (Hua et al., 2013, 2014). …”

Section: Introductionmentioning

confidence: 99%

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Evolved pesticide tolerance influences susceptibility to parasites in amphibians

Hua

Wuerthner

Jones

et al. 2017

Evolutionary Applications

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Because ecosystems throughout the globe are contaminated with pesticides, there is a need to understand how natural populations cope with pesticides and the implications for ecological interactions. From an evolutionary perspective, there is evidence that pesticide tolerance can be achieved via two mechanisms: selection for constitutive tolerance over multiple generations or by inducing tolerance within a single generation via phenotypic plasticity. While both mechanisms can allow organisms to persist in contaminated environments, they might result in different performance trade‐offs including population susceptibility to parasites. We have identified 15 wood frog populations that exist along a gradient from close to agriculture and high, constitutive pesticide tolerance to far from agriculture and inducible pesticide tolerance. Using these populations, we investigated the relationship between evolutionary responses to the common insecticide carbaryl and host susceptibility to the trematode Echinoparyphium lineage 3 and ranavirus using laboratory exposure assays. For Echinoparyphium, we discovered that wood frog populations living closer to agriculture with high, constitutive tolerance experienced lower loads than populations living far from agriculture with inducible pesticide tolerance. For ranavirus, we found no relationship between the mechanism of evolved pesticide tolerance and survival, but populations living closer to agriculture with high, constitutive tolerance experienced higher viral loads than populations far from agriculture with inducible tolerance. Land use and mechanisms of evolved pesticide tolerance were associated with susceptibility to parasites, but the direction of the relationship is dependent on the type of parasite, underscoring the complexity between land use and disease outcomes. Collectively, our results demonstrate that evolved pesticide tolerance can indirectly influence host–parasite interactions and underscores the importance of including evolutionary processes in ecotoxicological studies.

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“…The two types of pyrethroids cause toxicity through similar modulations of the voltage-gated sodium channels, but the degree of modification of sodium currents is different; single sodium channel currents are prolonged to a greater extent with type-II than type-I pyrethroids (Clark and Matsumura 1982;Nasuti et al 2003;Wouters and van den Bercken 1978). Organophosphates (e.g., chlorpyrifos) inhibit acetylcholine esterase activity (Hua et al 2013;Malison et al 2010) directly impacting the synaptic signal. Varying modes of action could thus drive various exposure effects among different test endpoints.…”

Section: Introductionmentioning

confidence: 99%

A comparison of the sublethal and lethal toxicity of four pesticides in Hyalella azteca and Chironomus dilutus

Hasenbein

Connon

Lawler

et al. 2015

Environ Sci Pollut Res

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Laboratory toxicity testing is the primary tool used for surface water environmental risk assessment; however, there are critical information gaps regarding the sublethal effects of pesticides. In 10-day exposures, we assessed the lethal and sublethal (motility and growth) toxicities of four commonly used pesticides, bifenthrin, permethrin, cyfluthrin, and chlorpyrifos, on two freshwater invertebrates, Chironomus dilutus and Hyalella azteca. Pyrethroids were more toxic than the organophosphate chlorpyrifos in both species. Bifenthrin was most toxic to H. azteca survival and growth. Cyfluthrin was most toxic to C. dilutus. However, cyfluthrin had the greatest effect on motility on both H. azteca and C. dilutus. The evaluated concentrations of chlorpyrifos did not affect C. dilutus motility or growth, but significantly impacted H. azteca growth. Motility served as the most sensitive endpoint in assessing sublethal effects at low concentrations for both species, while growth was a good indicator of toxicity for all four pesticides for H. azteca. The integration of sublethal endpoints in ambient water monitoring and pesticide regulation efforts could improve identification of low-level pesticide concentrations that may eventually cause negative effects on food webs and community structure in aquatic environments.

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Cross‐tolerance in amphibians: Wood frog mortality when exposed to three insecticides with a common mode of action

Cited by 34 publications

References 30 publications

Evolved pesticide tolerance in amphibians: Predicting mechanisms based on pesticide novelty and mode of action

Evolved pesticide tolerance in amphibians: Predicting mechanisms based on pesticide novelty and mode of action

Evolved pesticide tolerance influences susceptibility to parasites in amphibians

A comparison of the sublethal and lethal toxicity of four pesticides in Hyalella azteca and Chironomus dilutus

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