Cross-Tissue Comparison of Epigenetic Aging Clocks in Humans
Abner T. Apsley,
Qiaofeng Ye,
Avshalom Caspi
et al.
Abstract:Epigenetic clocks are a common group of tools used to measure biological aging – the progressive deterioration of cells, tissues and organs. Epigenetic clocks have been trained almost exclusively using blood-based tissues but there is growing interest in estimating epigenetic age using less-invasive oral-based tissues (i.e., buccal or saliva) in both research and commercial settings. However, differentiated cell types across body tissues exhibit unique DNA methylation landscapes and age-related alterations to … Show more
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