Cross Talk rebuttal: Schwartz and Gundersen

Schwartz, Lawrence M.; Gundersen, Kristian

doi:10.1113/jp283001

Cited by 4 publications

(2 citation statements)

References 11 publications

(12 reference statements)

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“… 108 Recent review papers and cross-talk debates have discussed the plausibility of myonuclear permanence with detraining, atrophy, and aging in great detail. 109 , 110 , 111 , 112 , 113 , 114 , 115 In summary, the current evidence suggests that myonuclei gained during exercise training may constitute a muscle memory in the short term (weeks to months), but are likely not permanent over the long term. The maintenance of myonuclei gained during exercise training may therefore not be a definitive explanation for muscle memory.…”

Section: Myonuclear “Memory” Of Past Training Adaptationsmentioning

confidence: 76%

Going nuclear: Molecular adaptations to exercise mediated by myonuclei

Koopmans

Zwetsloot

Murach

2023

Sports Medicine and Health Science

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Section: Myonuclear “Memory” Of Past Training Adaptationsmentioning

confidence: 76%

Going nuclear: Molecular adaptations to exercise mediated by myonuclei

Koopmans

Zwetsloot

Murach

2023

Sports Medicine and Health Science

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“…Myonuclear loss perhaps occurs as a strategy to stabilise the myonuclear domain. The prevalence and potential mechanisms of myonuclear removal was recently debated at length (Kirby & Dupont‐Versteegden, 2022a, 2022b; Schwartz & Gundersen, 2022a, 2022b) and is an open area of inquiry (Murach, Dungan et al., 2019; Eftestøl et al., 2020; Snijders et al., 2020; Rahmati et al., 2022).…”

Section: Introductionmentioning

confidence: 99%

The myonuclear domain in adult skeletal muscle fibres: past, present and future

Bagley

Denes

McCarthy

et al. 2023

The Journal of Physiology

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Most cells in the body are mononuclear whereas skeletal muscle fibres are uniquely multinuclear. The nuclei of muscle fibres (myonuclei) are usually situated peripherally which complicates the equitable distribution of gene products. Myonuclear abundance can also change under conditions such as hypertrophy and atrophy. Specialised zones in muscle fibres have different functions and thus distinct synthetic demands from myonuclei. The complex structure and regulatory requirements of multinuclear muscle cells understandably led to the hypothesis that myonuclei govern defined 'domains' to maintain homeostasis and facilitate adaptation. The purpose of this review is to provide historical context for the myonuclear domain and evaluate its veracity with respect to mRNA and protein distribution resulting from myonuclear transcription. We synthesise insights from past and current in vitro and in vivo genetically modified models for studying the myonuclear domain under dynamic conditions. We also cover the most contemporary knowledge on mRNA and protein transport in muscle cells. Insights from emerging technologies such as single myonuclear RNA-sequencing further inform our discussion of the myonuclear domain. We broadly conclude: (1) the myonuclear domain can be flexible during muscle fibre growth and atrophy, (2) the mechanisms and role of myonuclear loss and motility deserve further consideration, (3) mRNA in muscle is actively transported via microtubules and locally restricted, but proteins may travel far from a myonucleus of origin and (4) myonuclear transcriptional specialisation extends beyond the classic neuromuscular and myotendinous populations. A deeper understanding of the myonuclear domain in muscle may promote effective therapies for ageing and disease.

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