Cross-talk of inflammation and chondrocyte intracellular metabolism in osteoarthritis

Arra, Manoj; Abu‐Amer, Yousef

doi:10.1016/j.joca.2023.04.003

Cited by 18 publications

(10 citation statements)

References 90 publications

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“…Inflammation drives chondrocytes to express ECM-degrading enzymes, and the interruption of this pathway is a viable target to prevent cartilage degradation. It has been demonstrated that inflammation can alter the intracellular metabolism of chondrocytes, a process known as metabolic reprogramming [135]. Carlson et al detected 1233 metabolites in the synovial fluid (SF), representative of the most accessible tissue near chondrocytes.…”

Section: Relationships Of Octns With Altered Metabolite Profiles In I...mentioning

confidence: 99%

Inflammation and Organic Cation Transporters Novel (OCTNs)

Pochini,

Galluccio,

Console

et al. 2024

Biomolecules

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Inflammation is a physiological condition characterized by a complex interplay between different cells handled by metabolites and specific inflammatory-related molecules. In some pathological situations, inflammation persists underlying and worsening the pathological state. Over the years, two membrane transporters namely OCTN1 (SLC22A4) and OCTN2 (SLC22A5) have been shown to play specific roles in inflammation. These transporters form the OCTN subfamily within the larger SLC22 family. The link between these proteins and inflammation has been proposed based on their link to some chronic inflammatory diseases such as asthma, Crohn’s disease (CD), and rheumatoid arthritis (RA). Moreover, the two transporters show the ability to mediate the transport of several compounds including carnitine, carnitine derivatives, acetylcholine, ergothioneine, and gut microbiota by-products, which have been specifically associated with inflammation for their anti- or proinflammatory action. Therefore, the absorption and distribution of these molecules rely on the presence of OCTN1 and OCTN2, whose expression is modulated by inflammatory cytokines and transcription factors typically activated by inflammation. In the present review, we wish to provide a state of the art on OCTN1 and OCTN2 transport function and regulation in relationships with inflammation and inflammatory diseases focusing on the metabolic signature collected in different body districts and gene polymorphisms related to inflammatory diseases.

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Section: Relationships Of Octns With Altered Metabolite Profiles In I...mentioning

confidence: 99%

Inflammation and Organic Cation Transporters Novel (OCTNs)

Pochini,

Galluccio,

Console

et al. 2024

Biomolecules

View full text Add to dashboard Cite

show abstract

“…Similarly, increasing evidence suggests that low-grade intra-articular synovial inflammation directly contributes to pain and radiographic progression of OA ( Sanchez-Lopez et al, 2022a ). To achieve therapeutic goals, such as pain reduction and prevention of structural damage in OA, targeting anti-inflammatory activity to mitigate the pro-inflammatory mediators produced by the synovium and cartilage of affected joints holds considerable promise ( Arra and Abu-Amer, 2023 ; Knights et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Network analysis, in vivo, and in vitro experiments identified the mechanisms by which Piper longum L. [Piperaceae] alleviates cartilage destruction, joint inflammation, and arthritic pain

Jo,

Baek,

Kim

et al. 2024

Front. Pharmacol.

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Osteoarthritis (OA) is characterized by irreversible joint destruction, pain, and dysfunction. Piper longum L. [Piperaceae] (PL) is an East Asian herbal medicine with reported anti-inflammatory, analgesic, antioxidant, anti-stress, and anti-osteoporotic effects. This study aimed to evaluate the efficacy of PL in inhibiting pain and progressive joint destruction in OA based on its anti-inflammatory activity, and to explore its potential mechanisms using in vivo and in vitro models of OA. We predicted the potential hub targets and signaling pathways of PL through network analysis and molecular docking. Network analysis results showed that the possible hub targets of PL against OA were F2R, F3, MMP1, MMP2, MMP9, and PTGS2. The molecular docking results predicted strong binding affinities for the core compounds in PL: piperlongumine, piperlonguminine, and piperine. In vitro experiments showed that PL inhibited the expression of LPS-induced pro-inflammatory factors, such as F2R, F3, IL-1β, IL-6, IL-17A, MMP-1, MMP-2, MMP-3, MMP-9, MMP-13, NOS2, PTGS2, PGE2, and TNF-β. These mechanisms and effects were dose-dependent in vivo models. Furthermore, PL inhibited cartilage degradation in an OA-induced rat model. Thus, this study demonstrated that multiple components of PL may inhibit the multilayered pathology of OA by acting on multiple targets and pathways. These findings highlight the potential of PL as a disease-modifying OA drug candidate, which warrants further investigation.

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“…While the specific pathogenesis of OA remains to be elucidated to date, several factors reportedly influence the progression of osteoarthritis, including obesity, aging, trauma, inflammation, osteoporosis, and joint deformities ( Millerand et al, 2019 ; Katz et al, 2021 ). Among these factors, inflammation is considered to play a crucial role in the occurrence and development of osteoarthritis ( Arra and Abu-Amer, 2023 ). Interleukin-1β (IL-1β) is one of several inflammatory factors that can lead to the occurrence of osteoarthritis by inducing the overexpression of related metabolic enzymes and inflammatory cytokines, such as NO, PGE2, ADAMTS, and MMPs ( Lin et al, 2020a ).…”

Section: Introductionmentioning

confidence: 99%

Bergamottin (Ber) ameliorates the progression of osteoarthritis via the Sirt1/NF-κB pathway

Shen,

Zhang,

et al. 2024

Front. Pharmacol.

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Osteoarthritis (OA) is a common chronic disease characterized by progressive cartilage degeneration and secondary synovial inflammation. Bergamottin (Ber) is an important natural derivative of the furanocoumarin compound, extracted from natural foods, such as the pulp of grapefruits and pomelos. Ber exhibits several characteristicsthat are beneficial to human health, such as anti-inflammation, antioxidant, and anti-cancer effects. However, the role of Ber in the treatment of OA has not been elucidated to date. Therefore, in the present study, in vitro experiments were conducted, which demonstrated that Ber reduces the secretion of inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase-2 (COX2), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) under the stimulation of interleukin-1β (IL-1β). Ber also reversed the IL-1 β-mediated aggrecan and type II collagen degradation within the extracellular matrix (ECM). In addition, in vivo experiments were conducted, in which Ber ameliorated the progression of OA in mice. It was revealed that Ber exerted its cellular effect by activating the Sirt1/NF-kB pathways. In conclusion, the present study demonstrated the therapeutic potential of Ber in the context of OA.

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Cross-talk of inflammation and chondrocyte intracellular metabolism in osteoarthritis

Cited by 18 publications

References 90 publications

Inflammation and Organic Cation Transporters Novel (OCTNs)

Inflammation and Organic Cation Transporters Novel (OCTNs)

Network analysis, in vivo, and in vitro experiments identified the mechanisms by which Piper longum L. [Piperaceae] alleviates cartilage destruction, joint inflammation, and arthritic pain

Bergamottin (Ber) ameliorates the progression of osteoarthritis via the Sirt1/NF-κB pathway

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