Cross Talk from Pets to People: Translational Osteosarcoma Treatments

Abstract

Osteosarcoma is almost identical in companion animals and in people, so research in basic cancer biology and treatment is readily translational across the species. In this article the authors (one DVM and one MD) present examples of species "cross talk" based on their parallel careers in musculoskeletal oncology surgery. Dogs in particular provide a relevant osteosarcoma model that is 10 times more prevalent than the corresponding human condition and offers a unique opportunity to answer questions related to local tumor control and metastasis. Advantages of the dog model include spontaneous development of the disease; the animal's large size, intact immune system, shared genetic aberrations, and response to traditional chemotherapies; and owners' acceptance and compliance with clinical trials for their pets. We describe several cross-species treatment strategies for osteosarcoma--chemotherapy, limb-sparing techniques, and radiation--as well as surprising impacts of infection and immunology. We conclude with some discussion of areas for further discovery and development to advance species cross talk in support of One Health.

Prognostic factors of early metastasis and mortality in dogs with appendicular osteosarcoma after receiving surgery: An individual patient data meta-analysis

“…Similarities between human and canine OS are striking and include thè bimodal age distribution, the high incidence of morbidity and mortality, the site of the tumor, histologic features and the response to the various treatment modalities (Withrow and Wilkins, 2010;Rowell et al, 2011). The biggest difference is that OS is much more common in dogs than in people.…”

Poster Presentations

“…Further studies are needed to assess whether this is due to lack of H 4 R upregulation in these specific NI models or NI in general, or a failure of 1 to detect this because of relatively high non-specific binding. 5 ]-Octreotide was conjugated to the carboxylate groups of the PAMAM dendrimer (G3.5) [1]. 99m Tc labeling was carried out by a direct method.…”

“…The PIP ligand was synthesized with various substituents in order to fine tune the physical properties of the corresponding Re(I) and Tc(I) complexes. Methods The new PIP ligands were synthesized by reacting 1,10-phenanthroline-5,6-dione, ammonium acetate, a diamine and glacial acetic acid in a one pot reaction at 125°C for 3 h. The Re(I) complexes were prepared in two steps starting from [Re(CO) 5 3 (PIP-R)(NMI)] in two steps. The quantitative formation of the final product was confirmed by HPLC and comparison to the corresponding Re(I) standards.…”

“…Afterwards, the EOE protecting group, which is mandatory for the successful introduction, was cleaved under acidic conditions. The subsequent purification should be easy done by cartridges due to the ionic nature of the precursors [5]. Objectives Hypoxic tumors are associated with poor radiotherapy outcome because of their increased resistance to ionizing radiation.…”

“…A further increase of its remarkable metabolic stability profile in vivo and favourable tumor uptake by coadministration of protease inhibitor phosphoramidon was unsuccessful. 3 Laboratory of Industrial Physics, University of Turku, Turku, Finland, 4 Institute of Biomedicine, University of Helsinki, Helsinki, Finland, 5 Memorial Sloan Kettering Cancer Center, New York, New York, United States Objectives Our aim was to develop and evaluate with SPECT/CT imaging and fluorescence microscopy a biocompatible porous silicon nanosystem for the delivery of the antiangiogenic drug sorafenib in a mouse model of prostate cancer. Methods The carboxylic acid residues on UnTHCPSi particle surface were modified with dibenzocyclooctyne-PEG 4 using EDC/NHS coupling, followed by copper-free click conjugation of azido-modified Alexa Fluor 488, and DOTA [1].…”