Cross talk between vestibular neurons and Schwann cells mediates BDNF release and neuronal regeneration

Verderio, Claudia; Bianco, Fabio; Blanchard, Marie Pierre; Bergami, Matteo; Canossa, Marco; Scarfone, Eric; Matteoli, Michela

doi:10.1007/s11068-007-9011-6

Cited by 37 publications

(35 citation statements)

References 61 publications

(66 reference statements)

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“…On the other hand, in Schwann cells co-cultured with inner ear vestibular neurons, vesicular exocytosis of BDNF was triggered by activation of the P2X7R. Released BDNF in turn supports vestibular neuron survival and growth [135]. These studies reveal that stimulation of growth factor release considerably broadens the impact of ATP on cell proliferation, differentiation and development.…”

Section: Growth Factorsmentioning

confidence: 87%

Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release

Zimmermann

2015

Purinergic Signalling

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Extracellular nucleotides, and ATP in particular, are cellular signal substances involved in the control of numerous (patho)physiological mechanisms. They provoke nucleotide receptor-mediated mechanisms in select target cells. But nucleotides can considerably expand their range of action. They function as primary messengers in intercellular communication by stimulating the release of other extracellular messenger substances. These in turn activate additional cellular mechanisms through their own receptors. While this applies also to other extracellular messengers, its omnipresence in the vertebrate organism is an outstanding feature of nucleotide signaling. Intercellular messenger substances released by nucleotides include neurotransmitters, hormones, growth factors, a considerable variety of other proteins including enzymes, numerous cytokines, lipid mediators, nitric oxide, and reactive oxygen species. Moreover, nucleotides activate or co-activate growth factor receptors. In the case of hormone release, the initially paracrine or autocrine nucleotide-mediated signal spreads through to the entire organism. The examples highlighted in this commentary suggest that acting as ubiquitous triggers of intercellular messenger release is one of the major functional roles of extracellular nucleotides. While initiation of messenger release by nucleotides has been unraveled in many contexts, it may have been overlooked in others. It can be anticipated that additional nucleotide-driven messenger functions will be uncovered with relevance for both understanding physiology and development of therapy.

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Section: Growth Factorsmentioning

confidence: 87%

Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release

Zimmermann

2015

Purinergic Signalling

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“…There is an independent large literature demonstrating ATPenhanced release of cytokines from immunocytes via purine P2 receptors [for IL1 reviewed 109,110]. The immunocyte literature has been extended to the brain; ATP induces IL1, TNF and BDNF release from glia via P2 receptors [reviewed [72][73][74][75]111]. For example, both IL1 and TNF are released from microglia upon activation of the P2X7 receptor.…”

Section: Organization Of Sleepmentioning

confidence: 99%

The Role of Cytokines in Sleep Regulation

Krueger¹

2008

CPD

400

354

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Interleukin-1 beta (IL1) and tumor necrosis factor alpha (TNF) promote non-rapid eye movement sleep under physiological and inflammatory conditions. Additional cytokines are also likely involved but evidence is insufficient to conclude that they are sleep regulatory substances. Many of the symptoms induced by sleep loss, e.g. sleepiness, fatigue, poor cognition, enhanced sensitivity to pain, can be elicited by injection of exogenous IL1 or TNF. We propose that ATP, released during neurotransmission, acting via purine P2 receptors on glia releases IL1 and TNF. This mechanism may provide the means by which the brain keeps track of prior usage history. IL1 and TNF in turn act on neurons to change their intrinsic properties and thereby change input-output properties (i.e. state shift) of the local network involved. Direct evidence indicates that cortical columns oscillate between states, one of which shares properties with organism sleep. We conclude that sleep is a local use-dependent process influenced by cytokines and their effector molecules such as nitric oxide, prostaglandins and adenosine.

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“…Mediante el "cross-talk" no solo se ve favorecida la transmisión sináptica, sino que además, presenta una gran importancia en el proceso de crecimiento y diferenciación neural. Las células de Schwann producen factores como BDNF o neurotrofina-3, que resultan esenciales en el mantenimiento de la viabilidad de las neuronas y en el proceso de diferenciación neural (42) .…”

Section: Cultivos Bifásicosunclassified

“…La segunda compresión fue de 4 minutos a 140⁰C y 100 bares y la tercera compresión tuvo lugar a 140⁰C y 200 bares durante 20 segundos. Entre cada compresión se enfriaban las placas de la prensa hasta 60⁰C y con una presión de entre [40][41][42][43][44][45][46][47][48][49][50] bares. Además, se deben precalentar las placas durante 1 minuto antes de la segunda y la tercera compresión.…”

Section: Elaboración Del "Scaffold" 3d De Peaunclassified

Fibrin coating on poly (L-lactide) scaffolds for tissue engineering

Gamboa-MartÍnez

Ribelles

Ferrer

2011

Journal of Bioactive and Compatible Polymers

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A hybrid scaffold was obtained by the deposition of a thin network of submicron fibrin fibrils on the microporous walls of a macroporous poly(L-lactide) (PLLA) three-dimensional structure. The fibrin coating is homogeneous across the entire substrate and allowed the pore structure remain open in the hybrid scaffold. The elastic modulus of the hybrid scaffold (0.65 MPa) was increased up to twofold compared to the pure PLLA scaffold (0.29 MPa). Mouse pre-osteoblastic cells, MC3T3, were seeded on both pure PLLA and hybrid scaffolds, and cultured for 3, 6, and 24 h. The coating enhanced the cell colonization and proliferation and provided a more homogeneous distribution of cells within the scaffolds. In addition, the coating improved the scaffold adhesion properties by supplying new binding sites to the cells that modify the transmembrane receptors involved in initial cell adhesion mechanism. The expression of the β3 integrin was observed in cells cultured on fibrin-coated scaffolds instead of the α5 integrin, which was expressed in the uncoated scaffold. These hybrid PLLA/fibrin scaffolds have cell culture features suitable to promote early tissue regeneration.

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Cross talk between vestibular neurons and Schwann cells mediates BDNF release and neuronal regeneration

Cited by 37 publications

References 61 publications

Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release

Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release

The Role of Cytokines in Sleep Regulation

Fibrin coating on poly (L-lactide) scaffolds for tissue engineering

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