Abstract:Objectives: The cardio‐renal syndrome comprises a set of pathophysiological kidney‐heart interactions. Renal inflammatory conditions are able to promote the release of inflammatory cytokines, which may act through cardiac TLR, promoting cardiovascular diseases such as cardiac hypertrophy (CH), as well as angiotensin II. This study aims to investigate a possible interaction between TLR and RAS in a model of CH induced by ischemic renal injury. Methods: C57BL/6 male mice (n=85) were subjected to surgical occlusi… Show more
Our studies show a central role for Ang II as a pro-inflammatory Toll-like receptor mediator in the pathogenesis of PH-exacerbated periodontitis, indicating that Ang II may be a reasonable target in patients with PH and periodontitis comorbidity.
Our studies show a central role for Ang II as a pro-inflammatory Toll-like receptor mediator in the pathogenesis of PH-exacerbated periodontitis, indicating that Ang II may be a reasonable target in patients with PH and periodontitis comorbidity.
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