Cross-talk between the circadian clock and the cell cycle in cancer

Soták, Matúš; Sumová, Alena; Pácha, Jiřı́

doi:10.3109/07853890.2014.892296

Cited by 120 publications

(115 citation statements)

References 128 publications

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“…Therefore, it is plausible that diffusible factors, including WNT, from secretory cells mediate the intercellular connection between the circadian clock and the cell cycle in ISCs and PCs. Interactions of the circadian clock and WNT signaling have been described previously in other contexts (Guo et al, 2012; Lin et al, 2013), and many genes in the WNT pathway are known to have rhythmic expression (Soták et al, 2014). Hence, not only WNT secretion but also downstream WNT signaling may contribute to clock-dependent synchronized cell-cycle phenotypes in vivo.…”

Section: Discussionmentioning

confidence: 78%

Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture

et al. 2016

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SUMMARY Circadian clock-gated cell division cycles are observed from cyanobacteria to mammals via intracellular molecular connections between these two oscillators. Here we demonstrate WNT-mediated intercellular coupling between the cell cycle and circadian clock in 3D murine intestinal organoids (enteroids). The circadian clock gates a population of cells with heterogeneous cell-cycle times that emerge as 12-hr synchronized cell division cycles. Remarkably, we observe reduced-amplitude oscillations of circadian rhythms in intestinal stem cells and progenitor cells, indicating an intercellular signal arising from differentiated cells governing circadian clock-dependent synchronized cell division cycles. Stochastic simulations and experimental validations reveal Paneth cell-secreted WNT as the key intercellular coupling component linking the circadian clock and cell cycle in enteroids.

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Section: Discussionmentioning

confidence: 78%

Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture

et al. 2016

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“…Daily oscillation of hepatic and metabolic enzymes is observed in human studies 17 26. In addition, clock genes are pivotal in the regulation of cell apoptosis and proliferation 27. Night shift work causes circadian misalignment between workers’ activity and the normal rhythm of the liver.…”

Section: Discussionmentioning

confidence: 99%

Night shift work and abnormal liver function: is non-alcohol fatty liver a necessary mediator?

Wang

Zhang

et al. 2018

Occup Environ Med

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ObjectivesAccumulated evidence implies that night shift work may trigger liver dysfunction. Non-alcoholic fatty liver (NAFL) is suggested to be a necessary mediator in this process. This study aimed to examine the relationship between night shift work and elevated level of alanine transaminase (e-ALT) of workers and investigate the potential mediation effect of NAFL.MethodsThis study included all male workers from the baseline survey of a cohort of night shift workers. Information on demographics, lifestyle and lifetime working schedule was collected by face-to-face interview. Liver sonography was used to identify NAFL cases. Serum ALT level was detected by an automatic biochemical analyser. e-ALT was defined as ALT >40 U/L. Logistic regression models were used to evaluate ORs, and mediation analysis was employed to examine the mediation effect.ResultsAmong 4740 male workers, 39.5% were night shift workers. Night shift workers had an increased risk of e-ALT (OR, 1.19, 95% CI 1.00 to 1.42). With the increase in night shift years, the OR of e-ALT increased from 1.03 (95% CI 0.77 to 1.36) to 1.60 (95% CI 1.08 to 2.39) among workers without NAFL. A similar trend was not found among workers with NAFL. In addition, no significant mediation effect of NAFL in the association between night shift work and e-ALT was found.ConclusionsNight shift work is positively associated with abnormal liver function, in particular among workers without NAFL. Shift work involving circadian disruption is likely to exert a direct effect on liver dysfunction rather than rely on the mediation effect of NAFL.

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“…P16 can compete with cyclin D1 binding to CDK6 or CDK4 and thus specifically inhibit CDK4 or CDK6 activity, eventually leading to cell cycle arrest at G1 phase (49,50). WEE1 is a key gene for G2/M phase arrest, inhibition or downregulation of WEE1 kinase could lead to mitotic catastrophe in glioblastoma cancer cells (31,32).…”

Section: Discussionmentioning

confidence: 99%

Anticarcinogenic effects of water extract of sporoderm-broken spores of Ganoderma lucidum on colorectal cancer in vitro and in vivo

Sang

et al. 2017

International Journal of Oncology

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Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) have been used as traditional Chinese medicine for cancer prevention for many years. However, the mechanism by which GLP exerts its chemopreventive activities remains elusive. In addition, it is unclear whether sporoderm-broken spores of G. lucidum water extract (BSGLWE), which contains mainly GLPs, has anticancer effects on colorectal cancer. The present study investigated the anticancer effects and potential mechanisms of BSGLWE on colorectal cancer in vivo and in vitro. Our results showed that BSGLWE significantly inhibited colorectal cancer HCT116 cell viability in a time- and dose-dependent manner. Flow cytometry analysis indicated that BSGLWE disrupted cell cycle progression at G2/M phase via downregulation of cyclin B1 and cyclin A2, and upregulation of P21 at mRNA levels. Moreover, BSGLWE induced apoptosis by decreasing Bcl-2 and survivin at mRNA levels, and reduced Bcl-2, PARP, pro-caspase-3 and pro-caspase-9 at protein levels. Furthermore, BSGLWE suppressed tumor growth in vivo by regulating the expression of genes and proteins associated with cell cycle and apoptosis, which was further confirmed by a reduction of Ki67, PCNA, and Bcl-2 expression as determined by immunohistochemistry staining. NSAID activated gene-1 (NAG-1), a pro-apoptotic gene, was significantly upregulated in vivo and in vitro upon BSGLWE treatment at both mRNA and protein levels. In addition, the relative amounts of secreted NAG-1 in cell culture medium or serum of nude mice were all upregulated upon BSGLWE treatments, suggesting a role of NAG-1 in BSGLWE-induced anticolorectal cancer activity. This is the first study to show that BSGLWE inhibits colorectal cancer carcinogenesis through regulating genes responsible for cell proliferation, cell cycle and apoptosis cascades. These findings indicate that BSGLWE possesses chemopreventive potential in colorectal cancer which may serve as a promising anticancer agent for clinical applications.

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Cross-talk between the circadian clock and the cell cycle in cancer

Cited by 120 publications

References 128 publications

Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture

Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture

Night shift work and abnormal liver function: is non-alcohol fatty liver a necessary mediator?

Anticarcinogenic effects of water extract of sporoderm-broken spores of Ganoderma lucidum on colorectal cancer in vitro and in vivo

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