Cross-Talk between P2X and NMDA Receptors

Rodriguez, Larry; Yi, Catherine; Chu, Cameron; Duriez, Quentin; Watanabe, Sharyse; Ryu, Megan; Reyes, Brandon; Asatryan, Liana; Boué‐Grabot, Éric; Davies, Daryl L.

doi:10.3390/ijms21197187

Cited by 15 publications

(9 citation statements)

References 43 publications

(89 reference statements)

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“…142 It is reported that both P2X2 and P2X4 interact with NMDARs in an inhibited manner. 143 Ca 2+ entry through P2X2Rs or P2X4Rs…”

Section: Stress (Csds) Conditional Knockout Of P2x2 Receptors In Pyra...mentioning

confidence: 99%

The neurobiological mechanisms and therapeutic prospect of extracellular ATP in depression

Wang,

Huang,

et al. 2024

CNS Neurosci Ther

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BackgroundDepression is a prevalent psychiatric disorder with high long‐term morbidities, recurrences, and mortalities. Despite extensive research efforts spanning decades, the cellular and molecular mechanisms of depression remain largely unknown. What's more, about one third of patients do not have effective anti‐depressant therapies, so there is an urgent need to uncover more mechanisms to guide the development of novel therapeutic strategies. Adenosine triphosphate (ATP) plays an important role in maintaining ion gradients essential for neuronal activities, as well as in the transport and release of neurotransmitters. Additionally, ATP could also participate in signaling pathways following the activation of postsynaptic receptors. By searching the website PubMed for articles about “ATP and depression” especially focusing on the role of extracellular ATP (eATP) in depression in the last 5 years, we found that numerous studies have implied that the insufficient ATP release from astrocytes could lead to depression and exogenous supply of eATP or endogenously stimulating the release of ATP from astrocytes could alleviate depression, highlighting the potential therapeutic role of eATP in alleviating depression.AimCurrently, there are few reviews discussing the relationship between eATP and depression. Therefore, the aim of our review is to conclude the role of eATP in depression, especially focusing on the evidence and mechanisms of eATP in alleviating depression.ConclusionWe will provide insights into the prospects of leveraging eATP as a novel avenue for the treatment of depression.

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“…142 It is reported that both P2X2 and P2X4 interact with NMDARs in an inhibited manner. 143 Ca 2+ entry through P2X2Rs or P2X4Rs…”

Section: Stress (Csds) Conditional Knockout Of P2x2 Receptors In Pyra...mentioning

confidence: 99%

The neurobiological mechanisms and therapeutic prospect of extracellular ATP in depression

Wang,

Huang,

et al. 2024

CNS Neurosci Ther

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“…In addition to the above regulation mechanisms, NMDAR is also modulated by other pathways. Related studies have demonstrated that both purinergic P2X receptors (P2X2) and P2X4 interact with NMDAR in an inhibitory manner (Rodriguez et al, 2020). Meanwhile, SULT4A1 promotes the formation of the PSD-95/NMDAR complex to modulate synaptic development and function (Culotta et al, 2020).…”

Section: Influence Of Related Proteins and Signaling Pathways On Nmdarmentioning

confidence: 99%

Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy

Chen

Liu

et al. 2022

Front. Mol. Neurosci.

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Epilepsy is one of the most common neurological disorders characterized by recurrent seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N-methyl-D-aspartate receptors (NMDARs) play an important role in abnormal discharges, nerve conduction, neuron injury and inflammation, thereby they may participate in epileptogenesis. NMDARs belong to a family of ionotropic glutamate receptors that play essential roles in excitatory neurotransmission and synaptic plasticity in the mammalian CNS. Despite numerous studies focusing on the role of NMDAR in epilepsy, the relationship appeared to be elusive. In this article, we reviewed the regulation of NMDAR and possible mechanisms of NMDAR in epilepsy and in respect of onset, development, and treatment, trying to provide more evidence for future studies.

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“…P2X receptors further modulate the activity of GABAa receptors ( Boué-Grabot et al, 2004 ; Toulmé et al, 2007 ; Jo et al, 2011 ), nACh receptors ( Khakh et al, 2000 ), and 5-hydroxytryptamine receptor 3A ( Boué-Grabot et al, 2003 ; Emerit et al, 2016 ; Soto et al, 2020 ). Coexpression of P2X receptors and NMDARs in oocytes showed that they interact via the C-terminal domain of NMDAR, and their activation inhibits NMDAR-dependent currents ( Rodriguez et al, 2020 ).…”

Section: The Nmdar Surface Cis-interactome: Current Viewmentioning

confidence: 99%

Regulation of membrane NMDA receptors by dynamics and protein interactions

Petit‐Pedrol

Groc

2020

Journal of Cell Biology

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Understanding neurotransmitter system crosstalk in the brain is a major challenge in neurobiology. Several intracellular and genomic cascades have been identified in this crosstalk. However, the discovery that neurotransmitter receptors are highly diffusive in the plasma membrane of neurons, where they form heterocomplexes with other proteins, has profoundly changed our view of neurotransmitter signaling. Here, we review new insights into neurotransmitter crosstalk at the plasma membrane. We focus on the membrane organization and interactome of the ionotropic glutamate N-methyl-D-aspartate receptor (NMDAR) that plays a central role in excitatory synaptic and network physiology and is involved in the etiology of several major neuropsychiatric disorders. The nanoscale organization and dynamics of NMDAR is a key regulatory process for glutamate synapse transmission, plasticity, and crosstalk with other neurotransmitter systems, such as the monoaminergic ones. The plasma membrane appears to be a prime regulatory compartment for spatial and temporal crosstalk between neurotransmitter systems in the healthy and diseased brain. Understanding the molecular mechanisms regulating membrane neurotransmitter receptor crosstalk will likely open research avenues for innovative therapeutical strategies.

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Cross-Talk between P2X and NMDA Receptors

Cited by 15 publications

References 43 publications

The neurobiological mechanisms and therapeutic prospect of extracellular ATP in depression

The neurobiological mechanisms and therapeutic prospect of extracellular ATP in depression

Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy

Regulation of membrane NMDA receptors by dynamics and protein interactions

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