Cross-talk between neurons and glia: highlights on soluble factors

Gomes, Flávia Carvalho Alcântara; Spohr, Tania C. L. S.; Martinez, Rodrigo; Moura‐Neto, Vivaldo

doi:10.1590/s0100-879x2001000500008

Cited by 75 publications

(58 citation statements)

References 59 publications

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“…In any case, cholesterol is probably not the sole glia-derived factor that influences synapse development. Astrocytes synthesize a variety of components [40][41][42] and future studies will show which of these affect synapse formation directly without acting on neuronal survival or growth.…”

Section: Astrocytes Control Synapse Numbermentioning

confidence: 99%

New roles for astrocytes: Regulation of CNS synaptogenesis

Ślęzak

Pfrieger

2003

Trends in Neurosciences

198

121

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Section: Astrocytes Control Synapse Numbermentioning

confidence: 99%

New roles for astrocytes: Regulation of CNS synaptogenesis

Ślęzak

Pfrieger

2003

Trends in Neurosciences

198

121

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“…Os resultados obtidos apontam para uma redução no processo proliferativo celular com visível redução na proliferação glial de culturas tratadas com extrato de carqueja. As interações neurônio/glia tem sido responsáveis por diversos processos ligados a construção da arquitetura neuronal (Gomes et al, 2001). …”

Section: Resultsunclassified

“…Processos como neurogenese (Lim & Alvarez, 1995), formação sináptica (Pfrieger & Barres, 1997), proliferação (Gomes et al, 2001) e diferenciação (Garcia-Abreu et al, 1995) estão diretamente ligados a formação e manutenção do sistema nervoso central in vitro e in vivo. Fatores solúveis secretados tanto por glias e neurônios como neurotransmissores (Pereira & Araújo, 2001), hormônios e fatores de crescimento tem sido implicados na formação arquitetônica do cérebro (Gomes et al, 2001).…”

Section: Resultsunclassified

“…Fatores solúveis secretados tanto por glias e neurônios como neurotransmissores (Pereira & Araújo, 2001), hormônios e fatores de crescimento tem sido implicados na formação arquitetônica do cérebro (Gomes et al, 2001). Observamos também uma diminuição do crescimento de rede axodendrítica que poderia ter acelerado o processo degenerativo em nossas culturas experimentais.…”

Section: Resultsunclassified

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Atividade de Baccharis trimera (Less.) DC., (Asteraceae) sobre cultura de células in vitro

Losqui¹,

Rozete²,

Almeida³

et al. 2009

Rev. bras. farmacogn.

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RESUMO: O uso indiscriminado de plantas medicinais vem da crença de que produtos naturais não causam mal à saúde, porém assim como medicamentos sintéticos, as plantas possuem grupos de compostos farmacologicamente ativos que atuam nos organismos vivos, sendo necessário o conhecimento destes para avaliação de suas potencialidades terapêuticas e tóxicas. Estudos sobre propriedades químicas de plantas medicinais, associando o extrato destas às atividades toxicofarmacológicas, são pouco encontrados. O presente ensaio objetivou analisar a ação do óleo essencial de B. trimera (Less.) DC., espécie pertencente à família Asteraceae e popularmente conhecida como carqueja, sobre cultura de células do sistema nervoso central. Foram usadas células de retina de ratos neonatos tratadas pelo óleo de carqueja nas concentrações 1:500 e 1:1000, por um período de incubação de 4, 24 e 48 horas. Nossos resultados demonstram que a carqueja possui ação inibitória na diferenciação de células neuronais in vitro quando tratadas cronicamente. Observamos também uma redução na sobrevida de células neuronais e diminuição da proliferação de células gliais. Essa redução da proliferação de células da glia poderia estar interferindo na sobrevivência e diferenciação neuronal. Maiores estudos são necessários para se compreender os mecanismos envolvidos nesse efeito.Unitermos: Carqueja, óleo essencial, cultura de células, Baccharis trimera.ABSTRACT: "Activity of Baccharis trimera (Less.) DC. Asteraceae on culture of retinal ganglion cells in vitro". The indiscriminate use of medicinal plants comes from the belief that natural products don't cause harm to health, but as well as synthetic drugs, plants have groups of pharmacologically active compounds that act in living organisms, with the necessary knowledge of these groups to evaluate the therapeutic and toxic potential. Studies of chemical properties of medicinal plants, involving the toxicfarmacologics activities of these extracts are hardly found. This study aimed to analyze the action of essential oil of B. trimera (Less.) DC., a species belonging to the Asteraceae family and popularly known as carqueja, on cultured cells of central nervous system. We used retinal cells from newborn rats treated by carqueja's oil, with concentrations 1:1000 and 1:500, for an incubation period of 4, 24 and 48 hours. Our results showed that carqueja has inhibitory action on the differentiation of neuronal cells in vitro when treated chronically. We also observed a reduction in survival of neuronal cells and decreased proliferation of glial cells. This reduction of the proliferation of glial cells could be interfering with the survival and neuronal differentiation. Further studies are needed to understand the mechanisms involved in this effect.

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“…Moreover, interactions between glia and neuron-glia cross talk cannot be inferred from histological information as they take place in the extracellular space without direct cell-to-cell connections [ 126 ]. Currently, the dynamics of the cellular networks [ 127 -129 ] are studied using in vitro approaches [ 130 ], which provide a good footing to understand disease-specifi c modulation of network dynamics in vivo [ 131 ].…”

Section: Connecting the Elementsmentioning

confidence: 99%

Neurological Diseases from a Systems Medicine Point of View

Ostaszewski

Skupin

Balling

2016

Methods in Molecular Biology

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The diffi culty to understand, diagnose, and treat neurological disorders stems from the great complexity of the central nervous system on different levels of physiological granularity. The individual components, their interactions, and dynamics involved in brain development and function can be represented as molecular, cellular, or functional networks, where diseases are perturbations of networks. These networks can become a useful research tool in investigating neurological disorders if they are properly tailored to refl ect corresponding mechanisms. Here, we review approaches to construct networks specifi c for neurological disorders describing disease-related pathology on different scales: the molecular, cellular, and brain level. We also briefl y discuss cross-scale network analysis as a necessary integrator of these scales.

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Cross-talk between neurons and glia: highlights on soluble factors

Cited by 75 publications

References 59 publications

New roles for astrocytes: Regulation of CNS synaptogenesis

New roles for astrocytes: Regulation of CNS synaptogenesis

Atividade de Baccharis trimera (Less.) DC., (Asteraceae) sobre cultura de células in vitro

Neurological Diseases from a Systems Medicine Point of View

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